Huʻi myeloid leukemia

Huʻi leukemia - he maʻi o ka hematopoietic'ōnaehana, ma muli o - ka kona palena ka hoʻonuiʻana o kaʻeho keena, a nō kona morphological kūpapakū. Huʻi myeloid leukemia ma FAB Mea Maluna ua maheleia i ehiku koho. Ke kumu o ka Mea Maluna - o ka nui o ka differentiation o na keena ho i ka kūpapakū leukemia. Myeloblastsʻeho clone ua loko mai kumu keena, i ka poe hiki ke panalāʻau ulu helu o myeloid keena, megakaryocytes, erythrocytes, macrophages.

Ka loa pinepine malama Lolina M0-M3. Ke kumu o ka mea mua elua - keena ole differentiation. differentsirovanokletochny - m2 koho. M3 promyelocyticʻano ua wehewehe aku ma'āno'ē aeee i nunui mānoanoa. M4 a M5 - myeloblastic leukemia a me ka monoblastny. M6 - erythromyelosis, me ka mahuahua ka hoʻonuiʻana o ka erythroid keena. M7 - megacaryoblastic leukemia. O na koho a pau, a i hōʻike mai iā ia me ka huʻi myeloblastic leukemia, prognosis mea loa maikaʻi ka wā M0-m2.

etiopathogenesis leukemia

He aha ka huʻi myelogenous leukemia. Ka maʻi - hou hiki o aeee i mutations aie i ka hana o ka mawaho aʻe (ka pāhawewe, nā mea hoʻomaʻi, Nine Inch waiwai) a me ka predisposition i aaiaoe instability o ka genome. Kēia hualoaʻa ma ka ʻeho aeee hiki i kona palena māhele. Ka mea i hana i kekahi clone a, ma ka huli, ma ka puana mutations haawi ala i ka subclones.

ʻeho aeee i noke hua mai la i loko o ka iwi ka lolo, a me ka hahauʻino wale i maʻamau germ hematopoiesis. Ua, hele aku la lakou a hiki i kaʻike ākea koko, a metastasize i nā loko, ho okumu i nā foci o'āno'ē hematopoiesis. ? Ac? Aaioea myeloid leukemia me ka ano lapaʻau kiʻi no ia.

Ke Kalinika huʻi myelogenous leukemia

No ka mea, o ka hoʻohuikau o ka maʻamau hematopoiesis i loko o nā mea maʻi me ka anaemia, i ka helu o ka oo neutrophils a me platelets emi ia. Uuku au pōniuniu. nawaliwali ka hoomaopopo ana. Aia nā'ōuli o ke kahe ana ke koko: hemorrhages i loko o kaʻili, a mucous membranes, mahuahua kahe ana ke koko i menstruation, nosebleeds. Pain i loko o ka iwi, pehu lymph aka wahi o kekahi pūʻulu. Hoʻonuiʻia spleen a me ka akepaʻa. Ma muli o kāna hana hana o leukocytes, ho'ēmi i hoʻonele huʻi myeloblastic leukemia lua i pele ka piʻiʻana nā mea palahēhē. ua make pinepine hoike mai ai ia loa angina.

Ma ka hope o ke kahua i e pili na hoailona o ka hakuʻala 'ole a me ka neurological symptoms.

Ma kona pele huʻi myeloblastic leukemia kŰlń ao ka anu u ua kauohaʻia hoike ana, e kalaia mai ai, relapse. Ma ka hihia o ineffective lapaau ia na welau o ka maʻi ke kahua. Ke kahua o ka maʻi wehewehe aku ma kekahi lapaʻau symptoms a me ke koko kiʻi a me ka iwi ka lolo.

ʻike, o ka leukemia

Huʻi myeloid leukemia ua i ka cytochemical haʻawina keena ho i kona kūpapakū a me ka immunophenotyping - ka hoʻoholo 'myeloid hōʻailona. Morphological epekema no ka ka loaʻaʻana o ka hoʻohanuʻana keena ma ka hoomaopopo ana i ke 'ano o ka leukemia ua haawiia mai he hōʻike waiwai, a inā paha lākou e hoʻomau i ka ai.

I kekahi manawa, hoʻohana 'ia genotypic ki ina hana like ka nānā' ana ma luna o polymerase kaula naoh. Ua Ua hoʻohana 'ia e ho oholo i ka koena hoikeana o ka maʻi i loko o nā mea maʻi i loko o ke kala.

Huʻi myelogenous leukemia prognosis emi maikaʻi ma mua o ka prognosis o huʻi lymphatic leukemia. Up i ka 75% o ka hoʻomanawanui iki mai me ka kūpono kanaka loaʻa kala. Aia ka hōʻike o ka hoola ana o 20% loaʻa ke kala ana me ka hoomau mālama nui lapaau. Ke me ka paipai pū i nā hualoaʻa i loaa mai ma ka iwi lolo transplantation.