Papa "fenigidin": aʻo no ka hoʻohana 'ana, maoli

He aha mea i manaoia lapaau "fenigidin"? Na Ke Kumu no ka hoʻohana ana i ka 'inikua mea, e ho'ākāka' ia ma kona contraindications, aoao 'ole a me nā analogs ma au mamuli o keia Haawina. Eia hou, oe e aʻo i ka wa i haawiia mai ai ka lāʻau (nāʻikepili), i loko o ka laʻau heluna e e ia, i ka mea, olelo no ia, nā mea maʻi a me na kumu.

I ka haku mele 'ana a me ke ano o ke kalaʻana aku lāʻau

Uluwehi O "fenigidin" hiki ke loaʻa i loko o keʻena kūʻai lāʻau lapaʻau ma ka Akala a palapala. Lakou mau lole komoʻuʻuku nona, a iloko o ka hana 'Oponopono e like me nifedipine. Ma ke kuai ana o ka 'inikua Agena ua hāʻawi mai i loko o ka carton pahu, kahi e hiki e kekahi pellets 40, a me 50.

Mākou kekahi hookolokolo aku la ia i ka medicament hiki ke-market like me ka pāʻoihana no intravenous a intracoronary hooponopono. Kēia lāʻau he ka ia hana 'Oponopono me ka papa.

Pharmacological ano o ka ai '

He aha mea i ka lāʻau "fenigidin"? Na Ke Kumu no ka hoʻohana ana i ka lāʻau 'hākālia nō i ia mea he e wae kalipuna Kanal blocker ka papa 2, a me ka dihydropyridine nā mea loaʻa.

Keʻano papa hana o ka hana ana o keia k mea i ka mea, 'aʻole hoʻi kalipuna influx ma keena o vascular malimali Muscle a me cardiomyocytes. Ka lapaʻauʻia mea hiki ke kulia i ka hypotensive a me antianginal 'ole. Ua hoi Hoʻonui i ka pono o kaʻike ākea, a coronary arteries, emi ka leo o na moku, ho'ēmi i kā ke koko, systemic vascular ia'ku, myocardial contractility, i ke koi ana o ka naau Muscle o ka o oxygen, a ho'ēmi i kā ka afterload ma luna o ka naʻau. Eia hou, i ka lāʻau me ka nui loa? Ienoai aa coronary koko pele.

Papa "fenigidin" i uuku ai ole Anati-arrhythmic haʻawina. Eia hoi, aole lakou e ole e kaumaha ana myocardial conduction.

Pharmacokinetics o ka lāʻau

Where ke kemu lāʻau "fenigidin"? Na Ke Kumu ma ka noi hākālia nō ia ma hope o ka hookamaia ana o na papa i loko o kā lākouʻeleu waiwai ua hoʻomaka koke ke kemu, mai ka digestive'āpana. Ka lāʻau 'Ua metabolized ma ke akepaʻa. Kēia ia lŘlŘ ka wā i ka "mua alahele", kūpono ma ka ho okumu o AEeOEXAaI metabolites.

medicament kumuʻiʻo paa o ka hola 92-98%. Ka hapa-ola mau ma kahi o 2 h.

Nā lau lāʻau 'waiwai like metabolites ma unmodified ano (ma ka kumumea dala)ʻano nui puʻupaʻaʻelua. Nō hoʻi, i ka lāʻau 'o ia auoiaea ma ka naʻau liʻiliʻi (ma kahi o 20%).

Nāʻikepili no ka hoʻohana o nā lāʻau

Inā kekahi deviations kauka i koi 'ia kā lākou nā mea maʻi i ka lāʻau' like "fenigidin"? I ka hana o keia k hōʻike ma ka hahai pathological keia:

• i mea e pale akuʻo Kūhiō, a me vasospastic angina;
• no ke kokua o ka angina;
• ma hypertensive crises;
• arterial hypertension;
• Raynaud ka maʻi.

Contraindications i ka hoʻohana 'ana o ka lapaʻauʻia

Ma kekahi mau hihia, i ole hihia e ole e lawelawe i ka hoʻomanawanui i ka lāʻau "fenigidin"? Na Ke Kumu no ka hoʻohana ana i nā papa ma lalo o noonoo hākālia nō i ka mea i contraindicated i loko o ka hahai deviations:

• ma cardiogenic kŰia;
• arterial hypotension (systolic ke koko, i ka wa a kekahi i ka waiwai o ka emi o 90 mm o Hg ..);
• i loa aortic stenosis;
• i'opi;
• ma ka loa naʻau ole;
• ina o ka hoʻomanawanui i ka loa pā lonoaʻili i kaʻeleu hehee ai e like me nifedipine.

Nā Papahana O Ka noi a ka laʻau heluna o ka lāʻau

Ka lāʻau "fenigidin" ka manaʻo koikoi ua kuhikuhi wale i nā mea maʻi pākahi. No ka moʻolelo mea, i ka loiloi mua laʻau heluna o 10 mg eha manawa i ka lā.

Inā makemake, ka buke o ka lapaʻauʻia ua i nā mahuahua. Ma keia hihia, ka laʻau heluna makemake e 20 mg eha manawa i ka lā.

Ma kekahi wahi, i hiki lapaʻau (e laʻa me, Lolina angina, ole loa hypertension) no ka pōkole wā o ka manawa ua 'ae' e hoʻonui i ka lāʻau mahele lāʻau a hiki i 30 mg eha manawa i ka lā.

E hopu i ka hypertensive ulia, like hoʻi me angina, me ka lāʻau hiki ke hoʻohana 'ole-hōʻike waha a sublingually. Ma keia hihia ka mea, ua lawelawe i loko o ka nui o 10-20 mg (kākaʻikahi 30 mg).

No ke kokua ana i ka hoʻoponopono ulia hypertensive a me ka anginaʻeleu medicament kekahi manawa lawelawe intravenously (5 mg ma 4-8 hola).

Intracoronary bolus o ka lāʻau pāʻoihana lawelawe 100-200 mg. Oia lapaʻau ua ana i lawe mai no ka hoopau ana o ka huʻi coronary artery spasms. Vascular stenoses ka loiloi mua laʻau heluna E e pili ana i 50-100 micrograms.

ʻO kā mākou kela la i keia mahele lāʻau noʻonoʻoʻia e mākou medicament ma luna o 'ai, inu o 120 mg. No ka intravenous hoʻoponopono, kona leo e ole mamua o 30 mg.

ʻaoʻao 'ole o ka lāʻau

Intravenous pāʻoihana a me nā gula'ā'ī "fenigidin" e i kekahi 'ano nui helu o kaʻaoʻao loa. He aha ano o ka noʻonoʻo pono manawa:

• Mea'ōnaehana mānowai koko'ōnaehana: asystole, flushing o kaʻili, tachycardia, ventricular, ka waiʻona ma o ka wela, mahuahua angina ho'āhewa wale, tachycardia,ʻike ākea edema, hypotension, bradycardia.
• ʻike ākea a Central ko mākou hopohopo'ōnaehana: Muscle eha, headaches, kukui pilikia makapō haunaele, paresthesia, hiamoe o na kanaka haunaele a me ka tremor.
• Digestion: diarrhea, nausea, worsening akepaa, hyperplasia o ka nui aʻe ana. Inā 'oe e hoʻohana i ka lāʻau no ka lōʻihi, a me ka kiʻekiʻe nā māhele, loaʻa paha e dyspepsia, intrahepatic cholestasis a me ke kiekie ake transaminases.
• hemopoiesis'ōnaehana: loa kākaʻikahi mālama thrombocytopenia a me ka leukopenia.
• Endocrine System: gynecomastia kākaʻikahi malama.
• Urinary'ōnaehana: mahuahua kela la i keia mimi auaiaea. Inā e lawe i ka lāʻau no ka lōʻihi manawa, a me ka kiʻekiʻe nā māhele, loaʻa paha e ka 'aʻe' ana o nā puʻupaʻa.
• Allergy: ili wikiwiki.
• Local reactions: ina oe inject ka lāʻau intravenously, ia mea hiki i ke ahi ma ka ka pahu kui paena.

Kekahi e ole poina ia no kekahi minuke ma hope o intracoronary hooponopono, i ka hoʻomanawanui i ikea io inotropic hopena o ka nifedipine, a hoonui i ka naau i kela a me ke koko,. Mau symptoms nalo i nā hope ma kahi o 8-15 minuke.

lāʻau AaOIeIOUIeXAOAaIN me nā lapaʻauʻia

E hiki anei mākou, a me nā ai ', e lawe ka lapaʻauʻia "fenigidin Health"? Na Ke Kumu puni i loko o ka'ōpala, hoike aku nei ia i kanaka ola i me ka nui loa deteriorate ina mākou e noʻonoʻo e hoʻohana i ka laau lapaau pono. Ma keia manao, ma mua o ka hiki aku mākou Meu oe, e kukakuka pu me kou kauka.

Ka wā hoʻokahi-manawa noi o diuretics, antihypertensive konohiki a me ka phenothiazine nā mea loaʻa i ke hoʻokāʻoi antihypertensive hopena o ka nifedipine.

Me ka mea i ka wā hoʻokahi pono o anticholinergic ai 'i e hihia hoʻi noonoo ana a me ka hoomanao ana i loko o nā mea maʻi mālama'-hoʻomaha a me ka mea hoohuoi ia makahiki.

Inā i ka mea ia manawa e lawe i ka lāʻau me ka Hoʻokolohua-blockers, alaila, i ke kanaka e hoʻomōhala loa arterial hypotension, a ma kekahi mau hihia - a me ka naʻau 'ole.

Me ka mea i ka wā hoʻokahi pono me nitrates maoli he antianginal hopena o ka nifedipine.

Disposable? Eaia kalipuna emi ka ka hoʻokōʻana o kaʻeleu hehee ai. Keia ua pili me ka antagonistic AaOIeIOUIeXAOAaIN ma muli o ia, a mahuahua nui lehulehu o ke kalipuna Ion ma ka ai-kapaia extracellular loli.

Ikeia hihia o muscular nawaliwali, a me ka mau luhi ana e lawe i ka lāʻau me ka makanekiuma paʻakai.

Inā 'oe ke hoʻohana "fenigidin" pu me digoxin, ka mea hiki ke' ūlōlohi mai ana i ka wehe 'ana i ka hope, mai ke kino, i laila, i ke kumu o ka mahuahua ana o kona lehulehu i loko o ke koko.

A hoʻokahi-manawa mahele lāʻau o ka lapaʻauʻia me ka diltiazem hoʻokāʻoi aʻe ana i ka antihypertensive hopena.

Me ka mea i ka wā hoʻokahi pono o ka theophylline hoʻoneʻe 'ia paha e hoʻololi i loko o ka lehulehu o ka hope i loko o ke koko wai koko.

Rifampicin waiwai hiki ke inducing ake'ūhū hope, a hōʻeleu i pūnao o nifedipine, a ultimately hiki aku ai i ka nui emi i loko o kona laulā.

Inā hoʻohana o ka lāʻau i ka mea ia manawa me ka phenytoin, phenobarbital a me carbamazepine, me ka hiki wale mai e hoemi i ka lehulehu o na hana waiwai i loko o ke koko wai koko.

Aia nā hōʻike lehulehu o ka mahuahua ma nifedipine wai koko nā hoʻohui like a me ka hoomahuahua i loko o kona AUC i hookahi palapala noi me ka itraconazole a me ka fluconazole.

Inā e lawe i ka lāʻau me ka fluoxetine, e hoʻoneʻe 'ia paha, e hooikaika i kaʻaoʻao hopena o nifedipine ma luna o ke kanaka kino.

Ma pohihihi keia hihia, ka concomitant pono o ka lapaʻauʻia me ka quinidine ke emi i ka lehulehu o ka hope i loko o ke koko, a wehe i ka lāʻau '- me ka nui loa hoomahuahua ia, a, o ka papa, he hoʻonui i ka prolongation o ka QT wā mawaena ma ka electrocardiogram.

Na hana waiwai like ranitidine a me ka cimetidine, i kekahi manawa hoomahuahua i ka lehulehu o ka nifedipine i loko o ke koko, mahuahua kona antihypertensive ai.

Lapaau i loaʻa ka waiʻona i ke hoonui i ka hopena o ka nifedipine, ma o na la pōniuniu a me nā adverse reactions.

Medicine "fenigidin" i hāpai keiki, a lactation

Pololei lāʻau a kūpono ola haʻawina o ka hana hehee ai e like me nifedipine i hāpai keiki i ole ia. No laila, e hoʻohana i kēia k i gestation ua ole paipai.

Aie i ka mea ua hookuu ia nifedipine a me ka makuwahine o ka waiū, oe e pakele kona hoʻohana i ka umauma-e hanai ana oia i kekahi kamaiki a hana e paʻa lactation.

Ma mana haʻawina hoikeia mai embryotoxic, foetotoxic a me teratogenic hopena o nifedipine ma luna o ka wahine o ka kino.

Analogs medicament

Ka lāʻau 'hiki ke auou caiaiai "fenigidin"? mea i loaʻa i loko o nā keʻena kūʻai lāʻau lapaʻau Analogues o keia mea paahana. Iwaena o lakou i na kēia lapaʻauʻia: "Adalat", Sponif "," Vero Nifedipine, "" Sanfidipin "," Zanifed "," Osmo-Adalat "," Kaltsigard retard "," Nifecard "," Kordafen "," Nifelat " "Kordafleks", "Nifedipine", "cordipin", "Nifedikor", "Corinfar", "Nifedikap", "Nikardiya", "Nifedeks", "Nifadyev", "Nifegeksal", "Nifebene" a me na mea e ae.

Hāʻawi i kēia mau kālā e wale kauka.

Medicine "fenigidin": hōʻike manaʻo o nā kauka, a hoʻomanawanui iki mai

Mau loea, e hoailona oukou i ka laulā o ka lāʻau "fenigidin". Ua koke relieves angina, e like me kōkua me ka hypertensive crises, Raynaud ka maʻi, a me ka hypertension. Eia naʻe, ma ka aoao o nā mea maʻi, he nui na io manaʻo e pili ana i keia hoʻomākaukau. E like me ia ia lakou, ka mea e hookomo ana he nuiʻaoʻao ole. Ka loa pinepine hoikea mai oia, i Muscle aches a me ka pōniuniu. Eia naʻe, kauka e olelo aku i ka mea, e hiki mau reactions wale i ka wa a ka pololei ole noi o ka lāʻau. Ma keia manao, he mea pono e hoʻohana 'ia ma lalo o ka hooponopono ana o ka hoʻomalu wale, o ka oi aku ina ka hoʻomanawanui he huʻi myocardial infarction, loa aʻe' o cerebral holo, mimikō, kāna hana o ke ake, a puupaa, e like me malignant hypertension a me ka hypovolemia.