Posapahate mimikō: mea, lalau mai, symptoms,ʻike, lapaʻau

I keia la o ka honua Aneane mākua a pau ka ike ana i keia mai, e like me rickets. Ma ka pono no ka mea Kāohiʻana o kēia maʻi ua ālai 'o kēlā me kēia keiki ka kauka i loko o nā mahina mua o ka pēpē ka ola. Rickets pili i ka loaa ana mai, ulu ka i lawa cholecalciferol - he waiwai i kapa e like me ka wikamina D.

Naʻe, i loko o kekahi hihia i loko o nā kamaliʻi loa opiopio i symptoms o ka maʻi, hoʻowahāwahā i ka adherence i kāohi ana. Ma ia kekahi hihia e e kēia maʻi e like me posapahate mimikō. Like rickets, ka maʻi pili i ka aaiaoe pathologies. No laila, ka mea i oi loa mai, a koi i ka lōʻihi luna 'lapaau.

He aha ka ke posapahate mimikō?

Pela mea he pūʻulu o aaiaoe mai pili me ka hoʻopōʻino mea pōhaku pūnao. I kekahi pathology kapa wikamina D-hoʻopale rickets. Hoʻohakuʻano o posapahate mimikō ia lŘlŘ ma kahi o 1 keiki mai o 20,000 keiki keiki. i ka maʻi i ho'ākāka 'ia ma mua i loko o 1937. Hope ka mea, huli mai e loaʻa nō nā ano o aaiaoe abnormalities. Loa pinepine, posapahate mimikō ua 'akomi i loko o kakahiaka kamaliʻi. Ua,ʻo ka noonoo ana o na makua gait haunaele a me ka ei o ka iwi.

Kekahi ano o ka maʻi i pūʻia nā metabolic kāna hana. I kekahi manawa, i ka maʻi mea asymptomatic, a hiki wale kuhikuhi ia ma ke keʻena hoʻokolohua ho'āʻo ma. I ka maʻi ua hoʻolaha me ka loaa rickets, hypoparathyroidism a me nā endocrine abnormalities. Lapaʻau E e noniakahi ma ka koke elemakule.

Nā kumu o ka maʻi

Ke iniiaiie kumu o posapahate mimikō mea i hahau i loko o ka aaiaoe 'ole. Mutations i ili. Nā moku halihali mokulele o ka'āno'ē'ōewe hiki e nā wāhine a me nā kānaka. Ke mutation ia lŘlŘ i loko o ka X-chromosome ua hoʻopili, i mea Hoʻohaku. Ma pohihihi keia hoopii, posapahate mimikō hiki ke loaa. He hoʻomōhala ana i loko o ka hikoko o mesenchymal 'aʻaʻa, i hanaʻia i loko o utero. Ma keia pathology ua kapaia "oncogenic rickets."

Maʻi pili i ka hui tubulopathy - kāna hana no nā puʻupaʻa. No ka mea, nā minelala hao hoemiia reabsorption i loko o ka proximal tubule, ulu ka deficiency o phosphorus i loko o ke kino. Eia hou kekahi, nee na naau oʻu omo hiki. E like me ka hopena, ma laila nō nā loli i loko o ka mea pōhaku haku mele 'ana o ka iwi'aʻaʻa. Aia He pinepine ka 'aʻe' ana o osteoblast kuleana pili i. Men kekahi, pathologically hoololi'ōewe kaikamāhine wale nō, a me nā wāhine - keiki a nā sexes. E like me ka rula, o ka oi hanahana loa ka maʻi keiki kāne ma mua i loko o na kaikamahine.

Mea Maluna o posapahate mimikō i loko o na keiki

He nui na ano o ka maʻi, pu ole, ma aaiaoe a me ka lapaʻau 'Oihana. Loa mau diagnosed X-ua hoʻopili hypophosphatemic rickets, a i ka Hoʻohaku kumu o ka'āina hoʻoili. Eia naʻe, loaʻa nō nāʻano o ka pathology. Na Mea Maluna nā ka penei ke ano o ka maʻi.

1. X-ua hoʻopili Hoʻohaku type posapahate mimikō. Ua Ua wehewehe aku e loli PHEX'ōewe, a encodes ka endopeptidase. Kēia'ūhū He kuleana no ka halihali ana i nā nā minelala hao ma ka hakuʻala, a intestinal ion kaha. No ka mea, i kēia'ōewe mutation kaʻina 'aʻole hoʻi ia, e haawi ala i ka hoʻokō' ole 'ia e posapahate Ion i loko o ke kino.
2. X-ua hoʻopili recessive. Wehewehe aku CLCN5 mutation o ka'ōewe e encodes ke kumuʻiʻo kuleana no ka hana o ka chlorine ion kaha. E like me ka hopena o ke kina o Nyos halihali o ka waiwai ma kaʻili lahilahi o kaʻaʻa puʻuwai tubules. Nā moku halihali mokulele o kēia 'ano o ka pathology hiki e nā wāhine a me nā kānaka. Naʻe, i ka maʻi ia lŘlŘ wale i loko o nā keikikāne.
3. Autosomal Hoʻohaku kumu o posapahate mimikō. Ua Ua pili me ka aaiaoe mutation ma chromosome 12. No ka mea, osteoblasts pathological kina Ua kaʻawale kumuʻiʻo i paipai 'ia ka hoʻokāʻoi' posapahate pōpilikia 'ana mai i ke kino. Ke pathology Ua wehewehe aku ma kŘpa mehana, i kū'ē i ka X-ua hoʻopili palapala.
4. Autosomal recessive. Pohihihi keia. Wehewehe aku DMP1 hemahema'ōewe ua ke aupuni 'o chromosome 4. Ua encodes He kumuʻiʻo i mea kuleana no ka hooulu ana o ka iwi a me ka dentin.
5. Autosomal recessive, pu ma ke kala o ke kalipuna i loko o ka mimi. Kupu no ka mea, o ka'ōewe kina ke aupuni 'ma chromosome 9 a me kaʻoihana o ka paʻakai-e kaukaʻiʻaʻa puʻuwai kaha.

Ma waho aʻeo ia mau ano o posapahate mimikō, loaʻa nō nāʻano o ka pathology. Kekahi mauʻano likeʻole o ka maʻi i ole, ua aʻo a hiki i kēia manawa.

Oko ao ma waena o rickets a me posapahate mimikō

Rickets a posapahate mimikō i loko o na keiki - keia mea,ʻaʻole loa a no ia mea, eia nae ka lapaʻau kiʻi o ka maʻi i kokoke'ālike. Ka oko ao ma waena o kēia mau pathologies ma ka etiology, aʻano papa hana o ka? Acaeoey. Ano o rickets - ia kuai maʻi pili i ka nele o ka cholecalciferol. Kēia waiwai a ua hua mai i loko o kaʻili ma lalo o ka aoao o ke Map. PalekanaEND_LINK mahele lāʻau o ka wikamina D ua i e lawe ma luna o kekahi kela la i keia manawa no nā mea a pau mamo, mai 1 malama i 3 makahiki, Ma waho aʻeo ka kauwela. Ma muli o ka hoʻokō 'ole' ana o cholecalciferol nee kalipuna omo kaʻina. E like me ka hopena o ka ulu iwi deformation.

Like ka posapahate mimikō ia mea i ka mea pili i ka congenital maʻi. A pau keia pathology nee omo o nā minelala hao i loko o ka hakuʻala, i pau - na phosphates. Ma kekahi mau hihia, he mea kalipuna deficiency. Ma muli o ka 'aʻe' ana i ka mea pōhaku haku mele 'ana o ka iwi'aʻaʻa pathologies e like symptoms. Ke koena unuhi ma waena o ia hiki ke hookupaa ma hope o ke keʻena hoʻokolohuaʻike, wale.

Hypophosphatemic rickets i na kamalii uuku: symptoms

Symptoms o ka maʻi i ana diagnosed i ka lua o ka makahiki o ke ola. Ma pohihihi keia hihia, he mea hypophosphatemic rickets i loko o na kamalii uuku. Symptoms i hiki ke diagnosed iʻuʻuku mai - he muscular hypotonia a me ka lala hua'ōlelo. I ka papa kuhikuhiE lapaʻau hoike ana i:

1. Deformation o ka'ūhā ami.
2. O-hoʻokino curvature o ka laloʻaoʻao.
3. Ulu retardation i keiki - i kekahi 'ma hope o 1 makahiki.
4. Ai hanaʻia naʻe o ka pulima a me ka iwiʻaoʻao cartilage - "rachitic kūpeʻe lima a me nā lei."
5. Pain i loko o nā iwi o nā pelvis a me ka spine.
6. Poino o ka niho enamel.

Loa pinepine o ka papa kuhikuhiE hoopii ana o na makua i ka i lena i ka pēpē i ka wāwae. Me ka Holomua o ka maʻi he mea kekahi i hoopalupaluia, no na iwi - osteomalacia.

ʻike, o ka posapahate mimikō a me rickets

E huai ae abnormalities, alakai aku ia i ka ao o ka biochemical haku mele 'ana o ke koko. Ua Ua kaulana hypophosphatemia. i ka nui o ke kalipuna i loko o ka hapanui o na hihia maʻamau, i kekahi manawa - ua hoʻemi. Ma ke kiekie o ka rickets he mea ka mahuahua ana o kona'ākilikai phosphatase. I ka X-kukuna hōʻike osteoporosis a me ka ulu ana o ka iwi? Aie? 'Aʻe'. Ma ka mimi i hōʻike mai i ka nui nui o phosphates. I kekahi manawa, he mea urinary kalipuna.

Lapaau ana o rickets a me posapahate mimikō

No ka iapaau ana o posapahate mimikō i hoʻohana nui nā māhele o ka cholecalciferol. Ma kekahi mau hihia, hōʻike kalipuna kumukanawai. E hōʻoia i ka hoʻohana lapaʻauʻia e loaʻa phosphorus. E hoʻoikaika i ka ano o ka hoakakaia wikamina a me ka mea pōhaku kumukanawai. O D. nā ka "Vitrum" ai ' "Duovit", "Hawaiʻi" a no laila, ma luna o.

I ka wa i olelo ia curvatures o nā iwi hoikeia physiotherapy, physical Inc, aʻoki kino. E nīnau aku i ka podiatrist.

Kāohi ana a me Time]

No ka Kāohi ana nā ka nānā 'ana a me ka pediatrician surgeon, he hele i loko o ka hou lewa, i ka hookohu o ka wikamina D, mai ka malama mua o ke ola. Inā ka ohana i ka mai o ka posapahate mimikō E undergo aaiaoe ikea ai i loko o utero fetus. Ka olelo wanana a ka hapanui maikaʻi me ka 'eleu lapaau.