"Acecardol": nā kuhikuhi no ka ho'ohana, nā kuhikuhi, nā mana'o ho'ohālikelike, nā'ano like

Ma waena o nā kumu o ka antiplatelet therapy, ka mea i ho'ohana'ia no ka pale'ana i nā ma'i o ka ma'i a me ka ma'i,'o ka acetylsalicylic acid (ASA) he wahi ko'iko'i no ka wā lō'ihi. Ho'okumu'ia i ka makahiki 1887, ua'oi aku ma mua o 125 mau makahiki i ho'ohana'ia i ka hana olakino e like me ka hana ma'amau a me ka antipyretic. A ma ke'ano lā'au lā'au lapa'au, he māhele ia o ka lā'au lapa'au "Acecardol",'o nā hō'ailona no ka ho'ohana'ana o ia mea e ho'onui like me ka ho'omohala'ana i nā mechanical pathogenetic o nā ma'i vascular.

'O ke'ano o ka pūnaewele

'O ka mea hana o ka lā'au lapa'au e like me ka ho'ohālikelike pili i nā mea e pale ai i ka hō'ino. I loko o kēia pū'ulu,'o ASA ka pūnaehana hō'omi māmā maoli, hiki iā ia ke hō'oia pono i ka hiki'ole ke hō'ili'ili'ia o ka loko i'a a pau. Ke hō'oia'ana i ka lā'au'ona "Acecaradol", nā hō'ailona no ka ho'ohana'ana, nā analog a me kona'ano hana mai ka mana'o o pharmacodynamics, hō'ike'ia kēia mau mea:

• 'O kāna mea hana - ASA, ka'imi'ana i ka hopena antithrombotic e pili ana i nā keleheki atherosclerosis;

• Ho'oma'o pono'ia ka lā'au lapa'au no ka pale'ana i nā ma'i cardiovascular;

• 'O kāna mea hana he mea ho'emi ia i ka hopena o ka ma'i o ASA;

• 'O ka lā'au lapa'au e'oi aku ka uku nui ma nā hoa ho'okūkū me ka hana like.

'O ka hopena o ka pale'ana i ka thrombosis o ka ASA ma muli o ka pāpa'i i ke kūkulu'ia'ana o ka prostanoids. Ma muli o ka hana'ia'ana o nā kāleti COX-1 - cyclooxygenase-1 - ke kumu ho'okaho o ka ho'olālā thrombus -'o ka'āpana o nā platelets koko ke ha'iha'i'ia. Loa'a ka mana'o kaumaha o ke kūkulu'ana i ka Aromō Thromboxane, kahi e ho'omaka ai i ka hana o ka ho'okomo'ana i ka pāpale i kahi o kahi pala'ino o ka pā.

Ho'oponopono a me ka ho'ohālikelike'ana i ka momona

'O nā kuhikuhi kuhikuhi no ka ho'ohana'ana o "Acecardol" me ka pale o ka thrombosis. Eia nō na'e, ma ka ASA, ka mea hana o ka lā'au lapa'au, aia kekahi hopena maika'i'ole e pili ana me ka'ole o ka ho'ololi i ka cyclooxygenase. Eia kekahi, ua ho'opilikia'ia ka hoihoi'ana i nā pūnaepe epithelial o ka'āpana gastrointestinal. 'Oiai ma lalo o ka hopena ho'okūkū o ka'ele'ele'ele'ele waika, ua'oi aku ka'ino'ino o ia mau mea,'o ia ke kumu o ka ho'onui'ana i ka mumuna o ka momona. I kekahi manawa (e pili ana i 3.5% o nā hihia a pau) e ho'onāukiuki kēia i ka hanu i loko o ka'ōpala pahū.

No ke'ano hana i ho'ohana'ia ai "Acecardardol", ua lō'ihi nā hō'ailona no ka ho'ohana'ana i ka palekana loa. Hiki ia a ho'omele wale'ia i loko o ke duodenum, e pili ana i ka ASA. 'O kāna mea ma'amau me nā pūnaewele o ka'ōpū ka mea e hemo loa aku, a laila e kāohi ana i ka hopena o ka'ōpū. Ho'opi'i'ia ka hopena hana'ino o "Acecardol", no ka mea, ua'ike mua'ia ka lā'au lapa'au e like me ke'ano o nā mea ho'okomo i ke kikowaena i ke'ano he mea ho'olālā koho o COX-1. 'Oiai ka hana'ana o COX-2 i loko o ka'ōpū,'a'ole ia e hō'ike i nā pilikia nui.

'O ka hopena nui o ke'ano hana o "Acecardol" kahi i emi iho ka nui o nā mea'a'ai. Aie i ke alo o ka antacid i loko o ka palapala o ka makanekiuma hydroxide pahiki gastric poho emi i kiekie ae. A i kēia manawa ma ke kahua kū'ai pharmacological o ka Russian Federation, "Acecardol" kekahi o nā huahana'ekolu me kēia mau waiwai. Ke ho'omau nei i ka mea'oi aku i'oi aku ka'oi aku o ka mea kū'ai aku i nā mea like, ua kūpono e pili pono i ka ho'ohana mau.

E kau i "Acecardola" ma ka antithrombotic therapy

Ho'omaopopo'ia ka ASA no ka ālai'ana i nā hana pā'ani holomua ma muli o ke'ano o nā'ano noi'i haumāna. Ho'opa'a lākou i kona pono i ka ho'oha'aha'a'ana i ka make'ana o nā ma'i mai nā ma'i ma'i. Eia kekahi:

• Ho'olālā ka ASA i ka make'ana i ka 16% ma waena o nā ma'i i ka hui o ke kūpikipiki o ka cardiovascular ki'eki'e e 16%

• 25% ho'ēmi i ka hopena o ka hō'eha'ana i ka ma'i ischemic;

• 'O ka 25% e ho'ēmi i ka hopena o ka thromboembolism o ke anakū pulmonary a me kona mau lālā;

• Ma o 29% e ho'ololi i ka likelika o ka ho'olālā'ana i ka'ōhū'ino'ino o ke pelvis ai'ole nā hopena;

• Ma ke 33% ho'ēmi i ka hopena o ka hō'ailona o ka myocardial.

Ho'opiha pono kēia mau hopena a hā'awi i ka lā'au "Acecaradol",'o nā hō'ailona no ka ho'ohana'ana o ia mea he'oi aku ka nui a'e ma mua o ka wehewehe'ana o ASA. A i keia la o ka ikaika o ka mana antithrombotic o na antiplatelet hou ke hoohalikeia i ka hoohalike ana me ia. Nolaila, "Acecaradol", ma ke ano he mea palekana, pono e lilo i kahi kikowaena i ka lapaau prophylactic o ka poe mai e like me na kuhikuhi.

'O kahi ma'i o nā ma'i me nā hō'ailona no ka ho'ohana

'O ka lā'au'awa'au "Acecaradol" kuhikuhi no ka ho'ohana'ana, ke kumu kū'ai, ka maika'i a me nā pilikia o ka ho'ohana'ana ua pale maika'i'ia. 'O kēia ke kumu e lawe ai i ka ASA ma kēia'ano hopena ma nā'ano he nui o nā ma'i i loa'a nā pilikia kūpono. A i ka ho'opau'ia'ana o nā hopena hopena e pili ana i ka hopena i kēia mau kumu:

• (ACS) huʻi coronary syndromes me elevation, kaumaha a me kōna ST wā mawaena ma ka ECG;

• Me nā ku'i ko'iko'i o ke ka'a o ka cerebral (cerebral) (ONMC);

• transient (lolo) ischemic kaua (TIA);

• Ke ho'ololi'ia kēia mau ma'i i mea e pale ai i nā hihia hou;

• Me nā lā'au angina palekana no ka pale'ana i ka ACS;

• Me ka paroxysm a i'ole nā mana kūikawā o ka fibrillation'ōpiopio;

• Me ka ma'i o nā ma'i'ē a'e.

'O ka hō'ailona pilikino no ka ho'ohana'ana i "Acecardol"

'O kēia mau hō'ailona no ka ho'ohana'ana i "Acecardol" no ka hopena hopena o ka lā'au lapa'au. Ho'ohana'ia ia i mea hana e pale aku i ka thrombosis o ke an'a ma kahi o nā plaque atherosclerotic mahele. Ma kēia mau pūnaewele, ma muli o ke ku'ulua o ke an'a, hiki ke kahe i ke koko, me ka hana'ana o nā vortex e holo i ke koko. 'O ke kaomika mechanical ma nā'āpana o ka endothelium mīkini e alaka'i aku ai i kona kā'ili. Ho'omaopopo ka pūnaewele ho'ohui kala i kēia pūnaewele e like me ke ku'i'ana i ka hilina'i kūlohelohe, a'o ia ka mea e pono ai ka pa'a'ana o nā pae pā'ani me ka hana'ana i kahi thrombus.

'O ka hui'ana o nā pālahalaha ke'ano o ka papa hana mua o ka thrombus, a ma hope iho e hana'ia ka pūpū no ka thrombus e hiki mai. A laila, ho'onui'ia ka nui ma ka ho'oka'ulua'ana i nā pūpū koko. 'O ka ho'opiha'ana o nā hemostasis ke alaka'i'ia i kahi ikaika ('oi aku ma kahi o 75% o ka'āpana) e ku'ulua ana i ka lumen o ka moku. 'O ka manawa pinepine kēia i ka pīpī i ke koko i loko o ke kala, a'o nā wahi i hānai mua'ia mai ia mea, ua'ike'ia ka hopena. Hana kēia hana i ka ACS a me ka MMI, no laila, ke kuhi nui nei i kēia mau mea nui i mea e emi ai ka make'ana o nā kānaka me ke atherosclerosis o ke kī'aha ma'i a me nā ki'i brachiocephalic.

Ho'opi'i kahi'ālika "antitromboticheskogo" "Acecardola"

Ho'opili'ia i ka ho'omākaukau'ana i nā "Acecaradol" mau kuhikuhi no ka ho'ohana'ana (ka wehewehe'ana o ka lā'au lā'au)'a'ole ia e ho'ohālike i kona hopena pharmacodynamic, akā ua'ike'ia ma nā'ano o nā hō'ailona a me nā'ano hō'ailona. Eia na'e,'a'ole ia e wehewehe i ka hopena o ka ASA, no laila e ho'onele ai i ka mea ma'i i ka'ike nui e pili ana i ka hana hana. Ho'ohālike kona mau laina algorithms penei:

• Ka ho'ohaunaele o ka COX-1 a me ka ho'opau'ana o ke kahakaha o nā moekolohe;

• Ka pale hiki'ole ke hana'ia'o ka Arom e nā palette ki'i;

• 'O kahi mea pale i ke kipapalapala pāpale i nā hopena endothelial;

• Ka ho'oha'aha'a i nā hana o ka hui pū'ana i nā thrombocytes;

• 'O ka hiki'ole ke hana'ia i ka ho'ohui'ana i ka lumen o nā thrombus.

"Accekarol" ma nā kūlana ko'iko'i

Eia kekahi,'o nā kuhikuhi no ka ho'ohana (summary, description) i pili i ka ho'omākaukau'ana "Acecardol"'a'ole e hā'awi i ka'ike i ka mea ma'i no ka hiki ke ho'ohana'ia i ka ho'omohala'ana i nā pilikia e holo i ka na'au a me ka lolo. Ma ke'ano, me ka ho'omohala'ana i kahi ma'i hō'ailona o ka hopena o ka'eleococal a i'ole ka hō'ailona, hiki a ho'okomo'ia ka ASA.

Pono e'eli'ia nā papa o ka lā'au lapa'au (ma kahi o 150-300 mg), a'a'ole e'ānai'ia. Inā loa'a ka lā'au i ka lā'au 50 mg, a laila i ka manawa o kahi ma'i nui e koi'ia i ka manawa ho'okahi e pa'i 3-6 papa, inā he 100 mg ka lā'au, a laila 2-3 mau papa, inā 300 mg, a laila 1 pākaukau. He kōkua kōkua kūikawā kēia, a he mea nui e hō'emi'ia ai ka thrombosis ma'i nui.

Nā kuhiakau i ka ho'ohana'ana i "Acecardol"

'O ka lā'au'awa'au "Acecardol" (papa) a'o i ka noi, nā loiloi'ike a me nā hōkeo'ikepili hō'ike e hō'oia i ka pale o nā pilikia a me nā pono o ka ho'ohana. Eia na'e, pono e mālama i nā hō'ai'ē e pili ana i nā ma'i concomitant i ka wā e lawe ai i ka lā'au lapa'au a nīnau me kekahi kahu. Ua māhele'ia nā kuhikahi i mea mau (pa'a) a mau lō'ihi. Loa'a loa:

• 'O ka ho'omau'ole o ka lā'au i ka ASA, bronchospasm;

• Hematoma intracranial o nā'ano loiloi'oko'a;

• hemorrhagic vasculitis ;

• Ua Ua papaia e hana i loko o adolescents a me na keiki aie i ka pilikia o ko Reye ka maʻi pale ;

• He kapu i ka lawe'ana i nā wāhine i ka wā la'au'ana, ma ka lā mua a'ekolu paha o ka hāpai'ana.

Eia kekahi, ke'ano iki nei ka hō'ailona pili manawa a me ka pilina:

• He hō'ailona me ke kīnā'ole;

• Ka ho'omau'ana o ka holo'ana o ka holo'ana, ka manawa o ka ho'omaka'ana i ka manawa (ho'opi'i ka manawa);

• hypertension i ka manawa o ka hoʻoponopono ulia, kipi hypertension;

• 'O ka'ōpū o duodenum a me ka'ōpū i ka wā o ka exacerbation (ka palena kū'oko'a).

Nā Hua Hou o Acecardol

Ma waho a'e o nā hopena ma'amau a'ike maika'i'ia i ka hana'ia'ana o ka COX, he hana'ē a'e ka ACK. Ua hō'ike'ia ma nā hanana heluhelu ma'amau i nā pokapū a me nā kikowaena US. I ko lākou papa, ua hō'oia ka hopena maika'i o ka ho'ohana'ana i ka ASA no ka pale'ana i nā ma'i'ino -'o ka ma'i ma'amau o nā'ano loli.

I kēia manawa, ua hō'oia'ia kahi'ano hana o ka palekana o ka lā'au lā'au. Mana'o nā mana'o o ka po'e o nā noi'i a me nā kākikū e pili ana i ka hopena hana o ka COX-2 ma ka'ōpū lalo. I ka hō'ole'ana i ka inoa o prostaglandin E2, ASA hiki ke ho'oponopono i ka make a me ke kope o nā pūnaewele. Ma ke ala,'o kēia pūnaewele pūnaewele ka mea nui i ka ulu'ana i nā neoplasms tumora.

'O ka hopena ma ke kumu o nā mea i hō'oia'ia penei:'o ka lā'au lapa'au "Acecaradol", ke a'o'ana, ka noi, nā mana'oo ka'ike no nā mea e hō'oia'i'o ana i kona hopena palekana, hiki ke ho'ohana'ia a ma ke'ano he mea pale aku no ka pale'ana i nā hana ma'amau i nā'ao'ao ha'aha'a o ka'ōpū'ōpū. Loko o 5-12 makahiki loaa hoemi i ka pilikia o ka maʻi 'aʻai ka make, a he kūpono he ka lifespan. Akā na'e, hiki'ole ke ho'ohana'ia ka ASA no ka mālama'ana me ka adenoma āpau āpau a me ka carcinoma āpau.

Nā Analogs a me nā mea like'ole

Nā'ano o ka ho'omākaukau'ana o "Acecardol": noi, a'o, analogs, hō'ailona no ka hō'ailona antithrombotic e'ae ai e ho'ohana ia no ka mālama'ana i kahi āpau o nā ma'i. Eia nō na'e, ma ke'ano o nā mea āpau palekana,'a'ole'o ia wale nō ka lā'au lapa'au. I Rusia, aia he 20 mau koleka ASK generics, a ua hana'ia kekahi o ia mau mea i loko o ke'ano o ka'olo. Aia lākou ma ka pūnaewele palekana ma lalo o "Acecaradol".

'O nā'ano kikowaena o ASA ("Cardiomagnum", "Polokard"), i pani'ia ma ke kahua kū'ai pharmacological,'oi aku ka nui o ka uku. No ka lā'au lapa'au "Acecaradol" ke kumukū'ai o ka ho'oponopono'ana i kēlā me kēia malama he 25 rubles. Loa'a nā ana like o nā ana like me ke ana o ka spectrum pale mālama like'elua hapa-uku. 'O nā lā'au'ona'ē a'e a hana pālua a'elima paha ka nui ma mua o ke kumukū'ai o ka ho'oponopono kālā'ana me nā pono kūpono'ole no ka mea ma'i e lawe ana i "Acecaradol." 'O ke'ano o nā'ōlelo a'o no ka ho'ohana'ana, ka ho'omalu'ana, nā hō'ike'ana, nā hō'ailona o nā analogues o kēia lā'au lapa'au.

Nā hopena no nā pōmaika'i a me nā pilikia o nā analogues o "Acecardola"

Ke ho'omau nei i ka mea kū'ai aku i nā mea kū'ai aku,'oi loa ke kūpono o ka lā'au "Acecaradol" i nā koi o nā kauka. 'O ka pilikia o kona ho'ohana'ana ua kaulike'ia me ka ho'ohana'ana i ka ho'ohana pono'ana e like me ka luna ho'opihapiha. Ho'omaopopo kūpono ia i ka hana kuhumu pinepine o nā moku o ka na'au a me ka lolo, ho'ohana'ia i loko o ke'ano o ke kānilē, ke ho'ohana'ia nei i nā veins varicose. A i ka hoohalike ana i na analogues o ka moana, o ka pomaikai o "Acecardola" ke kumu kuai.

Ho'onui nui kēia mea i ka nui o ka lā'au lapa'au "Acecaradol":'o ke kumukuai o ka lā'au lapa'au he 20 mau'ūlā. He'u'uku loa kēia ma mua o ka uku o nā mea āpau'ē a'e. I kēia hihia ma ka lā'au ASA, i hana'ia i loko o ke'ano o ka hanu hiki ke ho'ololi'ia i ke koko, ma ke kumukū'ai ua pale pololei'ia'o "Acecaradol". He mea ma'amau ke hā'awi'ia'o ia i ka makemake i ka mālama'ana i nā ma'i i hō'ike'ia ma luna, a me kā lākou āpau. A mahuahua ka nui o nā'āpana o kāna noi.