Alanine aminotransferase mahuahua - he hoailona o ka hoʻoʻino a me ka degenerative keʻano o ka hanaʻana i loko o nā loko

Manawa aminotransferase migrating mai NH2-pūʻulu me ka γ-'aminoʻakika mau pou i ka acceptor - α-'aminoʻakika me ka waena kahua o ka'amoniuma. Ia mea, ke transamination (transamination: reversible hoolilo o ka'amino pūʻulu e ketoʻakika) - he kaʻina weheʻia kaulana Lūkiniʻepekema, a Kritsman Braunstein.

'amino nāʻakika (aspartic, glutamic a me ka alanine) i transamination hoohuliia mai i loko o ka like α-ketoʻakika, i nā eiiiiiaiou o ka tricarboxylicʻakika kalapona. Ma kā lākou'okesaside i loko o ka Krebs kalapona, ka mea, i ke kumu o ka ikehu.

Transamination mea nui ma ka hoomaopopo ana i ka urea kalapona aspartate.

I loko nō o ka mea i hiki e waiho kokoke ana i ka transamination reactions a me ka onaona'amino nāʻakika: phenylalanine, tyrosine a me ka tryptophan - he e pili ana i ka lapaau i loaʻa i ka wehewehena o ka ha awina o aspartate a me alanine aminotransferase. Mau nā'ūhū i hoʻomano māhele i loko o nā nā'aʻaʻa o ke kanaka kino.

Alanine aminotransferase nui ae la ka ula koko keena a me kona lehulehu, he eono manawa kiekie ae like i ka mea i loko o ke koko lāʻau lapaʻau. Ka mea kiekie loa lehulehu o ka'ūhū ua paa ma ke akepaʻa nā'aʻaʻa.

Alanine aminotransferase kūmau mea ole ka mea hookahi no na kanaka kino nā'aʻaʻa. No ka laʻana'ūhū hanana hulina i cardiac'aʻaʻa mea 7.1 (E * 10-3 g.'aʻaʻa homogenate), he ake - 44, skeletal Muscle - 4,8, hakuʻala - 19, spleen - 1,2, 0,7, a me ka akemāmā lāʻau lapaʻau - 0,016. Na epekema no ka manao paa o ka aminotransferase ha awina ma ka lāʻau lapaʻau ua maheleia i mau pūʻulu: ka endpoint (colorimetric, hoʻohanaʻike mau,ʻaʻole i hoʻolako pono me ka wela hoi malalo o cuvette photometric i hoʻomākaukauʻia) a me ka kinetic (spectrophotometric).

B6 mea he like wikamina i loko o ka likeʻole ma o kaʻai. Naʻe, ka mea e hoʻomanaʻoʻia ai ia ia iloko o ka imu kaʻina hana (thermal obrobka) ka wikamina ua luku. Pyridoxine mea he cofactor i loko loa nā'ūhū. Lehulehu pirodoksin-5-posapahate i loko o ke koko emi me ka elemakule. No laila, i ka ha awina o keia'ūhū ka alanine aminotransferase, ua hoʻemi i loko o kanaka mua o 64 makahiki (ma kahi o 30%) ma mua o ka poe elemakule 46-63 makahiki. I ka lehulehu o ka wikamina B6 i loko o ke koko lāʻau lapaʻau alanine aminotransferase mea, lalau mai.

E hoʻoholo i ka iaea ooieoeiiaeuiiai moku'āina o ke akepaʻa ua pinepine ho'āʻo aminotransferase pae i loko o ka hoʻomanawanui ka koko. O ke kumu ho kuhikuhi ana i ka mea e hoʻololi i loko o kā lākou hana ia lŘlŘ nui māmā ma mua o nā keʻena hoʻokolohua kiko'î. Hoʻopau (OAAIeOO) o ke akepaʻa nā'ūhū i loko o ke koko o ka PAaIEN o cytolysis - aeea ka luku a me ka hoʻohuikau 'o ko lākouʻili lahilahi permeability. A hiki ke kālailai i nā hoʻololi i loko o ka ha awina o nā'ūhū nui, e hookupaa aku i ka wahi o ka hoʻopau. Oe Pono e ike i kā lākou hanana hulina i loko o ke koko keena a me ke ola i ke kino, i ka subcellular IIeEeAIEUAA a me ka pūnao. Ka'ūhū lehulehu - alanine nui ae, pakahi aku la ia i loko o akepaa keena, nolaila, a hiki hōʻemi iki poino i kā lākou hoʻonāukiukiʻana mai o ka mahuahua ma'ūhū haʻawina i loko o ke koko. Ua haawiia i ka ha awina o ka'ūhū diagnose maʻi o ke akepaa (hepatitis, steatosis).

Alanine aminotransferase māhuahua necrosis o ke akepaa, a pēlā hoʻi me parenchymal hepatitis. Ka haahaa lehulehu o ka'ūhū ua kakau i ka maʻi hepatitis a me ka dystrophy. Ua pono e mai la oia i ka mahuahua ma ka aminotransferase ha awina ma ka lāʻau lapaʻau hoʻomaka 3-8 lā ma mua o ka hoouka kaua ana o ka papa kuhikuhiE lapaʻau hoailona o ka maʻi, a hiki i ka i kā mākou i loko o nā lā kakahiaka o? Acaeoey o ka pathological kaʻina.

Penei, alanine aminotransferase mahuahua: cirrhosis o ke akepaʻa, jaundice, ake Ka maʻi 'aʻai, myocardial infarction, pono naau e hemahema, hypoxia, kŰia, myositis, myocarditis, steatosis, pancreatin, maʻi alcoholism.