Cholinesterase nā mea kūpale: ka hoʻohana 'ana o ka pharmacological

Ua ua ike i ka ua'emi'ōnaehana he nui kona synapses. Ka mea, e pono no i ka EYI o impulses. Kēia kaʻina komo ai kekahi mau 'ano o ka' uao. Iwaena o lakou, - .., Acetylcholine, norepinephrine, me Gaba, serotonin, etc. uao (transmitters) e pono no ka hoololiia ana o ka lepa ma waena o neurons. A, ma muli o ia ia mea, ua lawe excitation paha inhibition musculature. Ma mau pathologies o ka'emi'ōnaehana neurotransmitters hana i ke hehiʻana. Kēia ka hana ma muli o ke atrophic a degenerative keʻano o ka hanaʻana i loko o ka lolo. Ma kēia hihia, hana ai 'e pono ai no ka amplifying paha attenuating ka EYI neaiaea. Ma ka like pharmacological pūʻulu i cholinesterase nā mea kūpale. Ka mea, i hoʻohana 'ia i loko o myasthenia, neuritis, amyotrophic kīloi paʻewa sclerosis, Alzheimer ka maʻi, psychiatric pathologies.

Kanawai o ka cholinesterase nā mea kūpale

Cholinesterase nā mea kūpale - i ka lapaʻauʻia i ua hoʻomano hoʻohana ma ka neurology a me ka psychiatry. Ka mea, ua māheleʻia i loko o kekahi mau pūʻulu, kela mea keia mea o ka i mea pili i loko o ka ua hihia. I ka hana o kēia mau ai 'hana ma ka paleʻana cholinesterase. Kēia'ūhū mea i loaʻa i loko o nā ola kanaka a me ka poe e loaa ana mai ka maʻi likeʻole. He mea pono e uhai iho i ka neurotransmitter - acetylcholine. E like me ka hopena o kona hana lēkio leo ke kūlana e choline a me aceticʻakika. Ma mau pathologies o ka lolo cortex atrophy ia lŘlŘ i nā. E like me ka hopena, i kekahi mau hale e'opi loa, a me ka cholinergic nenoaiu. Ma waho lolo atrophy, ua hiki aku i ka degenerative keʻano o ka hanaʻana o autoimmune, infectious, mea hoʻomaʻi ano. Manawa i ka make ana o ka forebrain nuclei he mea he haʻi nele i ka neurotransmitter - acetylcholine. Like loa me hiki i ole shortage o ka waiwai, e mea pono ke hana ma ka'ūhū i pepehi ia. No keia mea, i ka cholinesterase nā mea kūpale i hoʻohana. Mahalo iā ia, neurotransmitter hope e hoomau ana no kekahi mau makahiki.

Cholinesterase nā mea kūpale: ai 'Mea Maluna

He nui na ano o ka anticholinesterase ai '. Ka mea, e hoʻolaha, e like me ka pharmacological 'ole ma o ka'ūhū. Kekahi o ia i ka paleʻana cholinesterase irreversible, kekahi - ka manawa. Līkaia 3 pūʻulu medicaments. I waena o lākou:

1. Reversible blockers. Mau cholinesterase nā mea kūpale hana ma postsynaptic ka hōʻikeʻana. Mahalo iā ia, i ka'ūhū ua hulina i keʻakeʻa. Kēia pūʻulu nā acridines a me piperidine.
2. Psevdoneobratimye cholinesterase blockers. Lākouʻano papa hana o ka 'ana i loko o ka huipūʻana me onionovoy hapa o ka'ūhū lātoma. Eia hou, e hiki ke hoopaa i ka acetylcholine receptors mea. I kŰia mau mea i ka pae ana o carbamates.
3. Irreversible nā mea kūpale o cholinesterase. Kēia pūʻulu o ai 'ike i organo-phosphates mea. Lunamakaainana o kekahi medicament "Metrifonate".

I ka pae ana o acridines nā "mokulele lawe" ai 'a me "Velnakrin". Ka Poeikohoia carbamates - lapaau "rivastigmine", "Epistatigmin".

Nāʻikepili no ka pono o ka cholinesterase nā mea kūpale

Cholinesterase nā mea kūpale i hoʻohana e hana Muscle maʻi o kikowaena ka molekumu o, atrophy a me degenerative lolo kāna hana. Eia hou, i kekahi mau laau lapaau i loaʻa i loko o ke kino o na kulu. Ka mea, i hoʻohana 'ia ma ke kiekie intraocular puʻe - glaucoma. Ai 'i inhibit cholinesterase reversible, i hōʻike mai no ka iapaau ana o ka dementia, e koho i ka maʻi, a Alzheimer ka. Koho mea, e haawi aku piperidine pae, no ka mea, he poe e wae, a i poʻeʻuʻukuʻaoʻao ole. Ma nā makahiki, na nāʻikepili no ka hoʻohana ana ai 'mahuahua. O ke kumu ho i ka nui piha study o ko lākou mau waiwai. No ka maʻi i loko o ka a kauoha anticholinesterase ai 'nā myasthenia gravis, intestinal atony, muscular dystrophy, amyotrophic kīloi paʻewa sclerosis, lōlō o ka lala degenerative kumu. e hoʻohana 'ia nā mea kūpale Irreversible ma ka hihia o kaʻapu kōheoheo.

Contraindications i ka hoʻohana 'ana o ka cholinesterase ai'

Lapaʻauʻia i loko o kēia pae ua i hoʻohana 'ia i loko o convulsive kāna hana, hyperkinesis o kekahi etiology. Ka mea, i kekahi contraindicated i loko o nā mea maʻi me ka loa naau e hemahema, asthma, thyrotoxicosis. He undesirable e lawe anticholinesterases me concomitant gastric ulcer, enteritis. Laau ka mea,ʻaʻole e hōʻike 'ia i ka hapai keiki, a lactating wahine.

Cholinesterase nā mea kūpale: ke koho ana o ka ai 'no Alzheimer ka maʻi

Alzheimer ka maʻi - Ua atrophic CNS, ma a he mea amnesia, ke kanaka me kāna hana a me ka dementia. Epekema a puni ka honua e ho'āʻo ana e imi i ka laau no keia maʻi. I mehana a me ka lōpū oolea o ka maʻi o ka lāʻau o ka poʻe uʻi a "donepezil". Ua pili ia i ka reversible cholinesterase inhibitor, ua he e wae ia. A bear hoʻohana no ka mea o pathogenetic Inc. He mea i hiki ke hoola i ke ahonui loa, akā, 'aʻole hoʻi i ka ulu ana o Alzheimer ka maʻi symptoms.