"Epoetin alfa": manual, hōʻike manaʻo a me nā analogues

Uncharacteristic nui o ka lehulehu o ka hemoglobin - kekahi o na symptoms o ka anemia. I mea, keia mea,ʻaʻole heʻike, akā, wale symptom ia mea i keʻano o ka maʻi he nui loa. I ka holomua o ka maʻi i hōʻike i kekahi, iniiaiie lesion o ke koko nenoaiu.

Ke stimulator o erythropoiesis, ikeia like "Epoetin alfa" kauoha no ka hoʻohana me ke kiʻekiʻe hana hoʻonohoʻia mea kemikala pharmacological waiwai i kauohaia i ka lapaau a me ka Kāohiʻana o ka maʻi anaemia o okoa etiologies ma lalo o ka hoʻonohonoho 'ole-kūpono inoa. Pono koho laʻau heluna ua ole wale kōkua stabilize koko ke keʻena 'ole, akā, no ka mea, he maikaʻi ia ma luna o ka naʻau Muscle.

Release palapala a me ka Nine Inch haku mele 'ana

Ka lāʻau lapaʻau huahana mea i loaʻa i loko o keʻena kūʻai lāʻau lapaʻau ma ke ano o ka:

• sterile disposable 'ohe me ka paʻa mua mahele lāʻau (mea i manao ai? eaaaony no nā hoomalu paipu);
• pāʻoihana ma hue.

Ke kūlana o ke kākoʻo 'Oponopono ua haawi mai ai:

• injectable ka wai;
• koloriside dihydrate a me ka paʻakai hydrogenphosphate;
• polysorbate-80.

Ke liluwelo ha awina o ka waiwai i loko o ka hue hiki e okoa. Ma ka hapanui o na hihia, he tausani a elua tausani International Unit no 0.5 ml o ka wai. Eia naʻe, loaʻa nō kekahi kuai i kālā mea kemikala, a me "epoetin alfa" 10,000 pcs. / 1 ml.

Keʻano papa hana o pharmacological 'ana

Liluwelo a immunological waiwai o ka synthesized huahana e'ālike i maoli erythropoietin. Nolaila, ka lapaʻauʻia loa ka pono suppresses na symptoms o anaemia, a me ka pololeiʻiʻo nō ia i ke koko, e like me ka typical glycoprotein. Au pono aku nei au ia "epoetin alfa" kuhikuhi nona e māhuahua hematocrit a me ka hemoglobin pae normalization. Kona "naau hana," e like me ka ka welelau o ka eiiiiiaiou, e hoʻoikaika 'ana i ke koko kahe i na nā'aʻaʻa Ua emi hai.

hapa-manawa:

• ma intravenous ka pahu kui - eha hola
• ka wā injected subcutaneously me - e pili ana i ka lā.

ʻO kā mākou lehulehu o ka reactant i loko o ka wai koko no e manaoia ma hope o 12-18 hola.

pharmacokinetic nuances

Haʻawina Ua hoike ia i ka ho'ākāka 'ia ma ka lāʻau' induces ke kahua o nā mea'aʻaʻa ma ka "moe ko" 'ano, a me kona pharmacological nui i loko o ka keʻano o ka hanaʻana o ka iwi lolo fibrosis mea kokoke i' Aʻohe. Ke kumuʻiʻo mahele medicament "Epoetin alfa" oia no ma kahi o 165'amino nāʻakika (58% o ka huina hakakino kaumaha), a me keia i ka lewa ma ke degere a me ka pono o na eiiiiiaiou ho ololi i ka mahele / differentiation o ka hiki keena.

Hai intravenous hooponopono (i loko o ka wa e kaawale aku o kaʻaʻa puʻuwai pathologies) aole i alakai i ka hoʻomāhuahua o kaʻeleu waiwai; na keiki ma lalo o ka makahiki o ka 12 makahiki hoʻoneʻe 'ia paha prolongation o T1 / 2 manawa mai a hiki i 6 hola.

nāʻikepili no ka

"Epoetin alfa" ua pono no ka hoʻohana inā:

• anaemia diagnosed me he kāna hana o hematopoietic hana, i accompanies Ka maʻi 'aʻai (lawe wahi e e' ole-myeloid hikoko);
• ka hoʻomanawanui Kahalaopuna i ka pono no ka regular hemodialysis a peritoneal dialysis ;
• mea he ninau no ka hooko ana mai luna 'ʻoki kino me ka hoʻohana' ana o allogeneic koko transfusions;
• ka hoʻomanawanui ua iho mailoko me HIV a me ka loaa ana Inc ma luna o ke kumu o ka zidovudine;
• Ka heluʻaiʻana pono Kāohiʻana.

Ka mea e pono ai dosing regimen

No ka hoʻomäkaukau ' "Epoetin alfa", ka haʻilula no kanaka koho o ka kela la i keia mahele lāʻau. Eia naʻe, no ka nui koi o ka Hookah ua kaupalena i na rula a me ka hae:

• ma ka hoʻomaka '? iaea pae kanalima hana huahelu (Iu) no kilogram kino ke kaupaonaʻana, akā, i oi aku mamua o ekolu injections / infusions no hebedoma;
• i ka wa e kaawale aku o ka hiki naeaeaa: 75 huahelu / kg i ka ia wā mawaena, akā, mamua aku nei nō ma mua o hoʻokahi mahina i hope he lālā o ka lapaʻau;
• i loko o ka loaʻa kekahi pilikia: 100-200 U / kg, pololei loʻohia i aku la ka pahu kui haʻalele 'ana (ka anu u mahuahua - 25 huahelu / mahina);
• malama Inc: mahele lāʻau lawelawe i ka uku i ua ma ka hematocrit huahelu o 30-35 Vol. %.

E like me ka hana pono E hoike mai, no ka mea "maʻamau" ana ia hookahi ana o 30-100 Iu / kg, a ua hookuu kipaku i ka hope o ka dialysis. Ka e pono ai lōʻihi like 'ole o ka' olelo / V infusion - kekahi i mau minute; ʻano papa hana no ka subcutaneous haawi ana i ka hana 'ona e hahai i ka ia rula.

Mea Maluna o ka hiki adverse loa

Ma naoh nā mea e hiki wale mai atypical meaola ka i ke alo o ka lāʻau eiiiiiaiou "Epoetin alfa" manual mau moʻolelo ke kēia:

• hiki e visualize na symptoms ho'ākāka 'ia i ka maʻi palū nā mea hoʻomaʻi - loa pōniuniu, kaumaha, nawaliwali, kuni, loa amiʻeha / Muscle;
• ae na imbalances o ka naau a me ke koko arteries - he oi mahuahua i loko o ke koko,, malignant hypertension;
• kekahi hiki ole kāpae'ōlelo i ka pilikia o ka thrombocytosis (i ka maʻi, nae ka mea, i ka hookoia ka loa pohihihi, akā, ua fraught me ka mea complications);
• mea kemikala ma urinary'ōnaehana mea hiki ke ho ololi i ma ka hoololi ana i ka nui o ka potasiuma a me posapahate i loko o ke kino (i kipaku creatinine pae hoomahuahua i loko o ke koko wai koko).

Ma ka ili mea i kekahi manawa kekahi 'ae hookaawale triggered ma ka hoike ana o "Epoetin alfa" hoʻomākaukau. Na Ke Kumu, i pau, olelo o rashes, eczema, angioedema. A aha ka hana hoihoi ': ka wā subcutaneous ka pahu kui pakeneka oolea mea nui kiekie: ma ka awelika o ka tausani hihia, helu mahina no ma kahi o 4 Episode (me ka i / ma ka infusions - 1,6 wale).

Ma nā hoʻololi'ōnaehana paleʻea i makemake i mai la waiwai, i ike loea ike (noteworthy koe i ka hōʻike muaʻia aʻe hiki mai o ka lāʻau, e induce i ke kahua o nā mea'aʻaʻa).

E like me ka Hookah contraindications

Ma muli o ka 'ike i hōʻike' ia ma ka oihana alakaʻi, "Epoetin alfa" (analogs e like me "Binokrit" a me ka "Eralfon" ma keia manao like kokoke ana i ka palapala) e ole e hoʻohana inā:

• diagnosed me ka kipi hypertension;
• ke hoʻomanawanui i ka hoao ana hypersensitivity i na nā mea hoʻohui;
• Ka mua Ka Ikepili hōʻike i ka pilikia pathologies koko laina;
• ke hoʻomanawanui, waiho wale aku i ka naau kaua (mākou e kamaʻilio e pili ana i ka mea hou i hala);
• he mea kumu e manaoio i ka hoʻohuikau o maʻamau koko i loko o ka lolo.

Ma na olelo e ae, pono e ma mua ma ka 'inikua nana i ka hoʻomaka' ana o ka Inc.

Cautions

"Epoetin Alpha" (tradename structurally'ālike hoʻomanaʻo i e ano okoa - no ka hana, e like me ka hope hiki ke kaumaha analogs "Aeprin", "Repoetin-SP", "Epokomb", "Eprex", a pela aku ...) pono e hoʻohana me hoomahuahua ae la lakou e ku e mālama nui kanaka e loaa ana mai ka recurrent / maʻi kāna hana o kaʻike ākea nāʻiʻo. Keia rula He oi loa oiaio ina ka mōʻaukala me ka pane ana o ke kino a hiki i kaʻai ana o kekahi ai 'ua kākau Episode o convulsive reactions.

Ua 'Aʻole i ālai ia' aʻe me ka makaʻala, a no ka gout. Makau kuhohonu ana mua Pono e waiho i ka mea e pili ana i ke koko, a me ka hanana o headaches (antihypertensives - kekahi o na kēia mau 'inikua papa mākaʻi kiaʻi). Naʻe, ka mea mea like nui e loiloi, a me ka moku'āina oiaio o ka hao hale kūʻai (mua regular injections). I ka lawe ana mai kūpono hana ua ole lewa i loko o hua'ōlelo o ke koko,,ʻano hana i ho'ākāka 'ia pharmacological huahana ua hoʻi i kāpiliʻia.

E pono e hoomanao i ka hakuʻala holo pono, Ka maʻi 'aʻai, a HIV nō ma luna o ka papa inoa o ka maʻi i loko o ka papa o ka a, e kū'ē i ke kāʻei kua o ka hematocrit lehulehu, aia no he ano emi ma ferritin pae i loko o ke koko wai koko. E mitigate imbalances e akoakoa ai i ka hakahaka Inc ke komo pū Fe-i loaʻa reactants.

Eia kekahi laʻana no ka hemoglobin ka mea mea kupono, e lawe 1 manawa kela 7 lā. No hoi i ka Launch o elua mahina ua koi 'ia ka pololei, ka mālamaʻana o ka platelet helu. A no ka 5-10 lā ma mua o keʻoki kino, he ahonui ua lawelawe iho la no ka lapaʻauʻia kāleka waiwai nona antithrombotic waiwai.

Ke Hookah Aʻole e noho aliʻi ana i ka eiiiiiaiou o ka lāʻau e loli i kekahi mauʻano o ka hikoko, no laila, ke kilo o ka hoʻomanawanui Eʻaʻole e papani iho la i ke ahiahi, ma ka hopena o ka hana lapaau pae.

He aha e hana ma ka hihia o ka overdose?

"Epoetin Alpha" (synonyms-ai ', incidentally, hana i loko o ka like ano) me ka overdose hana e like me na algorithms hoohui i loko o ka Nine Inch haʻilula o recombinant erythropoietin a laila hoʻonāukiukiʻana mai o polycythemia hematocrit pae a me oscillations. Aie i ka nele o Classic antidotes, kekahi kūikawā ana no ka deactivation o nā mea hoʻohui ua i lawe mai - e hōʻoki aku i kekahi manawa ka lapaʻauʻia.

Intentional bloodletting pili i ka hihia o ka pilikia, i ka wa a ka ma-kali anakahi o ka hemoglobin Hōʻike he maoli hoʻoweliweli 'ana i ke ola.

Hana kūleʻa me nā lāʻau

Ma ka hoʻokō 'nunui-ke kahua luna' Inc ka loa nui e maopopo i nā loina o ka "pharmacological hana" "Epoetin alfa" mea kemikala (hoʻokuʻu palapala, e like me ka ho'ākāka 'ia ma luna, hiki e okoa, akā, i keʻano papa hana o keia biochemical naoh' aʻole e hoʻololi).

Pela, i ka nui, ia laua i ka hoike o ke koko huahana mai he maikaʻi ia ma luna o ka hoʻomaikaʻiʻana i nāʻano. Akā, ua pono hoomanao i ka dilution o ka pāʻoihana o kekahi mea inadmissible. Ka lāʻau 'Ua "hui" cyclosporin fraught me ka hōʻemiʻana lehulehu o ka hope (ka kaʻoi loa volumetric lākiō o na nā māhele ua nānā' empirically).

Comments

Ka Ikepili o ka manao hōʻike i ka nui helu o na ninau e ala mai ka wā e hele mai ai i na koho loaʻa no ka hoʻoponopono i ka ia pilikia. No ka laʻana, mau o ka hoʻomanawanui iki mai iā Kalani i ka oko ao i ka mea i wahi ma waena o ia pharmacological huahana, e like "epoetin alfa" a me ka "epoetin Hoʻokolohua."

He aha ka ke koena unuhi - oluolu i maopopo, inā mākou e lohe ai i ka manaʻo o nā kauka. Ka mea i ka mall kumu hoʻohālike o maoli erythropoietin ua poe ma na kaulahao elua, a me ka makemake ia ma luna o ke koko'ōnaehana i elua. Manufacturers hookahi lapaau, no ka mea, o ka mea oko ao ma ka enehana, a synthesize Alpha-apana nahaha paha Hoʻokolohua.

Like no me ka manaʻo ma luna o ka la hoomalolo ia iho, he nui o ka poe i, e hoao ia ia iho, hōʻike ana 'o ia hoʻi ia mea he pono, a ma kekahi kūikawā hihia, a ma nā mea a pau paʻa mau no kekahi mau waeʻano o nā mea maʻi.