I ka hope loa o ka hanauna o ka statin ai ': pono, kala, hōʻike manaʻo

Class statin ai 'i ua synthesized like me ka mea e emi ai ka nui o ka lāʻau lapaʻau naʻokoko, a emi mea'ōnaehana mānowai koko kamepiula. No ka lōʻihi manawa noiʻi a me na kumu hana wale me ka ai ', "Lovastatin," "Pravastatin" "Simvastatin", "Fluvastatin." Ua laila synthesized "Atorvastatin" a me ka "Rosuvastatin" - o ka hope hanauna o statins, a, e, i ka loa ka hoʻokō ai 'i loko o kēia waeʻano. Ua mea hoi a ianoiyuaa a underway e hoʻoikaika hou, i ka mea i oi palekana a me ka hoʻokō statins, i waena a me ka loa hanohano e pili ana i ka "pitavastatin."

General pharmacological ano o statins

All statins hāʻule i loko o ka waeʻano o ka ai 'e aloha ia lipid pūnao i loko o ke kanaka kino. Ka Anatomical pākōlea Nine Mea Maluna System laau ka mea, i koho karaima S10AA a me ka hai aku i nā mea kūpale o HMG-CoA reductase. Inhibiting Activity o keia'ūhū, ka mea ma loko o ka hoʻololi kemikala o ka naʻokoko, lāʻau lapaʻau me ka nui loa hoemi kona dala. statins kēia hana e leie aku e kū ai i ka paipaiʻia nā hoʻohui like o haʻahaʻa-pa apŘ lipids i loko o ke koko.

Mau waiwai e ka mea e hiki ai ia me ka nui loa emi i ka uku o ka? Acaeoey o atherosclerotic plaque. Pū ai 'ole kona hanana. E like ina ia mea i loaʻa i loko o ka waiwai hopena o statins: ka mea, stabilize ka endothelium o atherosclerotic plaque, ma keia manao, me ka nui loa emi i ka likelihood o coronary thrombosis, e hana ma ke 'ano' okoʻaʻano papa hana ma mua o antiplatelet Inc. A, i ka hui hoʻohana ana i mau dala e leie aku a hiki aku i ka emi i ka likelihood o ka naau hoouka. No ka mea, statins Ua hoʻouka kekahi ma luna o ke kumu keia i kuai ia mea oo hoaponoia.

Pakahi aku la ia statins Mea Maluna

Aia i mau hoʻokokoke mai i ka mahele i loko o nā papa o ka ai '. Ka mea hiki ke ike i ka hua'ōlelo o nā hiʻona hoʻololi kemikala. Nō hoʻi, mai ka iapaau ana o kekahi mau statins pono e auaaeaiea i loko o kekahi nā māhele mea kupono e hoʻolauna i ka Mea Maluna ma muli o ka paipai dosages. Mea Maluna o ka hanauna nana me keia:

• I hanauna "Simvastatin", "Pravastatin", "Lovastatin".
• II hanauna, "Fluvastatin."
• III hanauna "cerivastatin," "Atorvastatin".
• Hanauna IV "pitavastatin," "Rosuvastatin."

All statins i maheleia iʻimi hoʻopunipuni synthesized mai ka maka mau mea, a me ka kūlohelohe. Ka hope nā "Lovastatin," "Pravastatin" a me ka "Simvastatin". Kemikala ai 'i ke koena:. "Fluvastatin," "Atorvastatin", "Rosuvastatin" a me ka "pitavastatin"

Mea Maluna o statins i loko o nā māhele ke kaumaha ma muli o ka palapala noi

All papa o ka ai ', a me ka mea hope loa hanauna o statins, intelligently puunaueia i haahaa mahele lāʻau (8 mg), srednedoznye (10-40 mg) o kiʻekiʻe (40-80 mg). I ka pau:

• kiʻekiʻe-hoʻoʻino ai '( "atorvastatin", "Lovastatin" "Fluvastatin");
• srednedoznye ai '( "simvastatin", "pravastatin", "Rosuvastatin");
• haahaa mahele lāʻau ai '( "pitavastatin").

Kēia Mea Maluna Hōʻike 'i ka manawa kūpono o ka hoakaka ia a me kā lākou pākōlea huahelu. I ka nui, kiʻekiʻe-ai 'i he kanawai ma kiʻekiʻe dala, oiai pono tolerated. Srednedoznye ai ', akā, "rosuvastatin" emi pono tolerated ma kiʻekiʻe nā māhele, akā, i ka hopena maikai.

Srednedozny statin "Rosuvastatin" hiki ke lawelawe i loko o ka kiʻekiʻe laʻau heluna (80 mg), ina e pono ai, aka, no ka mea, o ka lawa piha ka ho'ēmiʻana o ka huina naʻokoko, a haʻahaʻa-pa apŘ hapa iki i ua pinepine i koi 'ia. "Pitavastatin" a me ka hana e noi mai ana i ka mākaʻikaʻi ma ka palena iki dala, no ka mea, o ka mea na ka pilikia o adverse reactions na manawa he nui haʻahaʻa ma mua ia o ka papa counterparts.

I ka moolelo o ka ana a me ka hoike ana o statins

Mōʻaukala o statins mea mahalo controversial. Initially, i ko lakou ulu ana ua nui hampered e ka nele o ka ike o ka naʻokoko pūnao a me ka likelihood o ka ulu atherosclerosis, ke kaumaha ma muli o ka pae ana o ke koko lipids. A, hookahi synthesized gopoholesterinemicheskie 'o ia hoʻi, e inhibit microflora ma ka hana' ike loea o ka hopena he, manaoia e loaa maemae penicillin. E wehewehe ana o ka naʻokoko-hakumakuma hana ana o ka helu o ka waiwai i lawe ia e fungi, a ua 'ā ka i ka hoʻopaʻa' ana o statins.

He lilo ka mua statin, compactin, aʻaʻole i hoʻolaunaʻia ma loko o lapaʻau mea ma muli o ka nui conflicting manao e pili ana i kona waiwai. Ua Ua kaʻawale mai ka moʻomeheu o Penicillium cetrinium. A laila, mai ka moʻomeheu o Monascus ruber ua kaʻawale monacolin K, Palapala Sila Nui ma Pepeluali 1979. Ma June 79th Palapala Sila Nui a me ka mevinolin, ka mea hope hoomaka ae la e lawe aku i ka inoa "Lovastatin". Kēia lāʻau ua hoʻohana 'ia i loko o ka? Aaieou, ma hope o ka mea i kaʻawale ai synthesized ma ka hope hanauna o statins.

A hailona no kū'ē manao statins inhibited ka hooulu ana, ma hope i ka mea i manao e hoʻomaka nui-unahiʻole, i lapaʻau e hookolokolo ai. I ka lā, i ka nui a me ka loa pono keia mau mea i ka hoʻopaʻa 'ana o Scandinavian Simvastatin Ola Study. Hoopokole kona inoa ua «4S». Ua Ua maopopo hōʻoleʻia kāna i ka manawa kūpono o ka carcinogenic mai e pili ana i ka lāʻau 'hoʻoponopono, a me ka lilo i kā lākou mau hana me ka nui loa maoli he ola expectancy a ho'ēmi i kā ka mea hiki wale mai o ka huʻi coronary pathologies.

Hōʻuluʻulu Manaʻo no ka pono o ka statins

A hiki i ka loiloi mua lehulehu o ka huina naʻokoko o 7,4 mmol / l, statin Inc, a ke hoʻokō i ka kiʻekiʻe o 5.4 mmol / L me ka nui loa ho'ēmi i kā ka pilikia o ka ona mea'ōnaehana mānowai koko hanana ma ka 40% ma luna o ka mea e hiki mai ana 5 makahiki. A helu o nā haʻawina i hōʻike i hookuu iho huina naʻokoko pae wale ma 1 mmol / L ma kekahi lima ho'ēmi i kā ka likelihood o coronary thrombosis, a nolaila naau hoouka a me ka hahau ana.

Noonoo pono i ka statins, na pros a me ka hooluolu ana o ka mea'ōlelo i ka puu o ka 'Oihana a me nā mea maʻi, ua hiki ke maopopo ka kēia kūʻiʻo: oe ke koi' ia ai 'i kakahiaka nui me na makahiki 40 a' oi, a me ka hoemi i ka ka pilikia o ka naau maʻi - i ka naauao tactic o ke hooloihiia ke ola. A mahope mai o statins kumukuai o loa ho'āmana, ua maopopo mau ai 'ka hoʻokō, hiki ke laweʻia me ka hoʻokaeʻili i kona iho Bedroom. O ka holo ana, o ka hope hanauna o statins ua ikaika nui ae pipiʻi, eia nae ka ia "Rosuvastatin" Ma rula, ia mea nō pipiʻi no ka hoʻomanawanui. A ka mea, o ka loa inexpensive palapala makaukau "Merten".

Me nā 'ano: Pros a me ka hooluolu

Ke kālailaiʻana statins, no ka a me ka ku e ia lakou e olelo nui wale. Manaʻo hoʻopiʻi kū'ē "no ka" mea i ka hiʻona o ko lākou pākōlea hana: ka ho'ēmiʻana o ke koko a me ka naʻokoko haʻahaʻa-pa apŘ hapa, hikiʻole i ka pilikia o ka huʻi hanana a me ke kōkua i loko o ko lākou nohoʻana. Eia naʻe, ai 'e like me statins, eia no hoi contraindications. Aia nāʻaoʻao loa, mediate manaʻo hoʻopiʻi kū'ē ana i ka palapala noi.

I ka Inc me statins i ka pilikia o ka myopathy. He paha mediated ma inhibition o ka hoʻololi kemikala o ka naʻokoko, a ua pono nāʻiʻo. Ke alapine (frequency) o kēia hookoia ka loa haʻahaʻa, a hiki no nae ia, a mahuahua nui ma ka coadministration me nā hypolipidemic konohiki. Aia mea no hoi i ka pilikia o ke akepaa Ka maʻi 'aʻai pathology, eia nae ka pahiki o ia i ka maʻi, e like me ka hoike ma nā haʻawina,'āina haʻahaʻa. Ma ka ia ai a me ka mea i ka maʻi 'aʻai i hoʻonāukiuki e' ē aʻe. Nolaila, ma ka hoomakaukau ana o ka "statins" E papa aku contraindications ke kākoʻo '-aaieieno? O mau ai' a me nā konohiki e paipai i ka emi i loko o ka lehulehu o ka momona keena.

Ke kumu o ka hope hanauna o statins

Ma ka hope loa hanauna o statins okoa kala, eia nae ko lakou mau waiwai i ke kumukuai o ka uku no ka. Kekahi ninau mea wale nō i ka hopena o kā lākou hana hiki e loaʻa me ka hoʻohana 'ana o ka ho'ēmi analogues ka papa mua hanauna. Ma 'ana, ka loa, he pono ole statin hanauna IV "Rosuvastatin" kumukuai o ka hola like penei:

• 600 rubles no ka papa o 40 mg;
• 400-450 ma ka papa 20 mg;
• 300-350 no ka 10 mg papa;
• 200 rubles 5 mg.

Ke AEeAaOA he 30 na papa, lawa no hoʻokahi mahina o ka lapaau, oiai ka malama lapaʻau "pitavastatin" kumukūʻai i ka hola like penei:

• 1 mg papa loaʻa ma kahi o 700-750 rubles;
• Papa 2 mg - ma kahi o 1000 rubles;
• papa 4 mg - ma kahi o 1500 rubles.

Ke koho ma waena o "Pitavastinom" a me ka "rosuvastatin" Ua nānā 'ana ma luna o eha ana hoʻohālike: kuai ololi, o ka uku o ka ho'ēmiʻana o haʻahaʻa-pa apŘ lipoprotein, kiʻekiʻe-pa apŘ lipoprotein māhuahua piha, e malu ai. I ka mämä holo o ka hakumakuma naʻokoko, a ulu HDL, e like me ke kumu kūʻai maikaʻi loa oi "Rosuvastatin", oiai theoretically oi maluhia o ka "pitavastatin."

Mau palua like pipiʻi ma ka e like me ka "rosuvastatin". Aka hoi, he mea i ka manawa kūpono o ka hoʻohana 'ē aʻe, ho'ēmi statins. Ka loa hoʻokele waiwai mea eʻoi aʻe mua i "Simvastatin". Ano ka mea, Ua UAIAaIN e "Atorvastatin", i ua mau UAIAaIN e "rosuvastatin" (kona waiwai, e pono haule). A ina statins hope hanauna kumukūʻai e unaffordable no ka hoʻomanawanuiʻana, ka mea i pono, e noonoo i ka manawa kūpono o ka hana maikaʻi "atorvastatin" a me "Simvastatin". Ma ke ala, loa haʻawina mālama 'ia me ka "atorvastatin".

'Oihana i loko o ke aloha o ka poʻeʻelemākule statins

Mua, clinicians i reluctant e koi 'ia statins i nā mea maʻi mua ma mua o 75 makahiki. Ke kumu o ke kēia mau kumumea:

• ? eaia, no kekahi mau 'ē aʻe papa o ka ai';
• ae makemake ole ohui i kekahi mahele o ka lapaʻauʻia;
• ka nele o ka ai haʻahaʻa komplaentnost lapaʻau;
• ka makemake ole o ka hoʻomanawanui iki mai, e kuai i statins, a, e hana ia no ka mea, o ka nele o ka naʻauao o ko lākou mau waiwai.

A helu o nā haʻawina lawe mai me ka "Simvastatin" "Pravastatin" a me ka "atorvastatin" hōʻike he nui emi i loko o ka palaho i loko o nā mea maʻi mua ma mua o 75 makahiki. A, i ka emi ana ma ka palaho ua i kona kiʻekiʻe ma mua ia o nā mea maʻi i loko o ka makahiki hui 55-65 a me 65-75 makahiki. No ka mea, no ka mea, ai 'ana i kēia papa (statins) loa mai ka poe akamai i pono keʻae i kekahi mea.

Mau lapaʻauʻia hiki e ia hope i loko o ke ola nānā 'ole o ka ina, he huʻi kahiko mea'ōnaehana mānowai koko kāna hana. A me nā mea maʻi i mea maoli nui nīnūnē e emi i ka pilikia o kona make ana, mai myocardial infarction paha hahau ana, e pono e ike ia ina ka lāʻau mea pono a me ka maluhia, ia mea maopopo leʻa ke kumukuai o ka lalau. Oi loa aku hoi i ka iapaau ana me statins ua lilo hou ho'āmana, a e mau ana me ia.

Features hōʻike manaʻo ma ka hope o ka hanauna o ka statins

Nā mea maʻi loa i loko o ke kālailaiʻana i ka mea e like ai o ka kekahi nōhie statins mea i hōʻike, no ka mea, i ole manao nui loli mai e lawe i ka ai '. Ka hoʻomaikaʻi koko lipid holoʻokoʻa 'aʻole i ikeia ma ka moku'āina o ke ola kino a me ka mai ole mawaho symptoms. Ua ke hoʻomaopopo iho i wale lipid pili. No ka mea, i ka wa a ka loiloi 'statin naʻauao alakaʻi i ka hōʻike mākaukau. A e pili ana i ka hoomakaukau ana i loko i ka hana 'Oponopono mea pitavastatin, i nā poe akamai i hiki ole pane.

Ma lapaʻau hana maʻamau ma ka Moscow "pitavastatin" no ka mea, o ka mea kiʻekiʻe lilo, a no ka mea, o ka alo o "rosuvastatin" a me kona generics aole i pili. I ka hoomakaukau "rosuvastatin", i mea hōʻike ma luna, i ka poe ola, hana: lipid holoʻokoʻa normalized 1-2 mahina. Ka "atorvastatin" ka manawa, a me ka hapalua kona manawa hou. I nōhie "rosuvastatin" lua pele, no ka mea, metabolized ka laha 'elua ma ka cytochrome. I ka manawa, ua laweʻia kēia 'ike mai o nā manaʻo o ka poe akamai, e Radio heʻano nui kūlana ma ke koho ana o ka statin ma kekahi wahi, i hiki lapaʻau.

Ke mau hopena o ka polokalamu hanauna o statins

Ai ' "pitavastatin" a me ka "Rosuvastatin" i ka loa nui i waena o ka poeikohoia o ka statin ka papa, no ka mea, a he nui kino o ka mea hoike i ohi ia. Ko lakou waiwai i nui like ai i ka poe o ka "atorvastatin", akā, ma laila nō oko ao. "Pitavastatin" a me ka "Rosuvastatin" ae, e holo nō ia, ka pale kaua naʻokoko pae, a me ka haahaa nuʻa lipoprotein i loko o ka haʻahaʻa laʻau heluna ma mua o ka "atorvastatin".

Ma waho aʻeo ia ka luna superiority statins hope hanauna mea nui a me ka mea i kekahi kēia lākiō. ʻo ia, ma ka iapaau ana o "pitavastatin" a me ka "rosuvastatin" malama i ka hoʻokēʻai normalization o ke koko lipids a me ka hoʻopau homocysteinemia. He mea nui kēia i loko o ka hihia o ka huʻi coronary maʻi, a me nā mea maʻi me ka maʻi coronary maʻi, triggered ma coronary atherosclerosis. Maluhia o ka hoʻohana 'ana i statins luna ma mua o kardioform acetylsalicylicʻakika. Aka hoi, i ke alo o ka contraindications ua papa kā lākou hoʻohana i kekahi hoomanawanui heluna kanaka (e nānā. General contraindications).

hoʻomanaʻo examples

Lapaau i loaʻa ka "Rosuvastatin" loaʻa ma lalo o ke kēia oihana inoa: "AKORT", "Rozistark", "Rozukard", "Rozart", "Merten", "Rozulip", "Roxer", "Rustor", "Tevastor". A pau o kēia mau ai 'i nōhie "Crestor" a lilo i ka mua rosuvastatin. Uluwehi O, ai kaʻeleu waiwai ka pitavastatin, kakau me «Livalo». Kona generics e «Pitavas» a «Pivasta». ka mea, e mai ana i loko o ka Moscow, eia nae helu i loko o ka Pharmacopoeia.

hōʻuluʻulu manaʻo

I kulike ai me ka papa o ka ai 'ole a me Ka Ikepili o ka laulā o ko lākou hoʻohana, ka hoʻohana' ana o statins ua palapala hopu no ka stabilizing atherosclerotic plaque a me ka ole kona ke kanana nei. Ua i hoʻohana 'e emi ai ka nui o ka atherosclerosis, me ka hoohuoi ana i ka lipid holoʻokoʻa o ke koko lāʻau lapaʻau. E like me ka hopena, keia ano o ka ai 'mea nō e pono ai ma ka cardiology. A me ka pono o ka mea hope loa hanauna statins mea, ua hoʻokō 'ano o ka Kāohiʻana o ka ona coronary thrombosis.