"Methotrexate" i loko o rheumatoid arthritis: hōʻike manaʻo. Na Ke Kumu no ka hoʻohana 'ana, he hōʻike o ka la hoomalolo

Rheumatoid arthritis, ina unuhi literally ia me ka Helene, pili ia i ka moku'āina o ka li nui. I ka ninau o ka mea Makaʻu hoʻonāukiuki aku i ka ulu ana o keia maʻi ua nō,ʻaʻole möakäka hou. ʻauhau'ēʻaʻe 'ike e maoli i ka helu ana o leukocytes i loko o ke koko, a mahuahua erythrocyte sedimentation kōmi (ESR), ʻo ia ka mea hiki ke manao nei makou i ke kaʻina hana o ka ulu i ka maʻi mea lele ano. Ua Ua manaoio aku i ka impetus no ka hooulu ana i ka maʻi o ka maʻiʻaʻai, e hoʻonāukiuki haunaele ma ka functioning o ka'ōnaehana paleʻea nenoaiu. Eia naʻe, malalo iho o keia, i nā mea a pau akā, ka poe wale ka poe i ka ohana mōʻaukala. Ka hopena o ka maʻiʻaʻai i hoʻolaunaʻia ma loko o ke kanaka kino o ke kahua o ka'ōnaehana paleʻea eiiieaenu (mai nā mea hoʻomaʻi, nā mea'aʻaʻa, a no laila, ma luna o. P.), Ka mea loaa ma na nā'aʻaʻa, a alakai aku i ka olelo poino.

Ma ka hapanui o hoopii, hana maikaʻiʻole o keia maʻi weliweli ka eha alleviating, ka meheu o ke kahe ana o ka maʻi kaʻina hana a me ka hoihoi hou ana i poho (e like me ka hiki i kēlā me kēia hihia) hoʻohanaʻoki lāʻau lapaʻau ki ina hana like.

Ai 'no ka iapaau ana a ianoiyuaa a i koe ma ka nui loa. Kekahi o kēia mau mea i ka "Methotrexate". Ma rheumatoid arthritis (hōʻike manaʻo o ke ola kino poe hana a me nā mea maʻi eʻae i kēia 'ike) i mai la medicament Ua pono ka lawa, i ka hopena o kona hopena, e e manao ia no ka lōʻihi manawa.

Haku mele 'ana a me ka hana

I ka papa kuhikuhiEʻeleu 'Oponopono o ka lāʻau mea methotrexate. Kēia nitostatik, he hoa o folicʻakika. Currently, no ka meheu o ka Holomua o rheumatoid arthritis lapaʻau kaʻina "methotrexate" ua hoʻohana 'oi pinepine ma mua o nā ki ina hana like. Ma o Mānoa, keia mea i ka antitumor lāʻau, he cytostatic Agena, inhibits mitosis (aeea maheleʻauhau'ēʻaʻe) inhibits i ka ulu ana o 'Imi proliferating nā'aʻaʻa, inhibits ka hooulu ana o ka hikoko.

Wahi a ka 'ikepili helu, ua malama i ka laulā o ka lāʻau i loko o 80% o nā mea maʻi, he maikaʻi au i kekahi' hope 2-6 pule ma hope o hoʻomaka Inc. Ma hope o kekahi wā lōʻihi o ka lapaʻau (i ka 5 makahiki) Inc "Metotraksatom" ana nui e emi ma mua o kekahi 'ē aʻe laau hoʻohana i ka' ūlōlohi i ke kūpono 'ana o rheumatoid arthritis.

Release ano o ka lāʻau

Pakiko ka lapaʻauʻia o ka Lūkini like paha o ka'Aukekulia "Methotrexate Ebewe". Ka palapala lāʻau Hookah kaumaha ana i kona nā mea kūʻai mai i loko o kekahi mauʻano ano o ka? Iecaianoaaiiuo. Papa i nā pāʻoihana i loaʻa i loko o ekolu dosages o 2,5 mg, 5 mg a me 10 mg o ka papa kuhikuhi hana ke keʻena. A pau o ia i piha i polypropylene hue o ka apana kēlā 50. Eia hou kekahi, "Methotrexate" (Austria - Hookah) hiki ke kuai ma kekahi mahele lāʻau o 50 mg / 5 ml i loko o ka pāʻoihana no ka pahu kui. Ampoules i ka pouli aniani a piha i loko o ka pepa pahu.

Ua mea no hoi e hiki ke kuai i kekahi medicament i loko o ka palapala o ke kiaʻana i kāna no ka makaukau o infusions (droppers). Laʻau heluna - 100 mg / 1 ml. Ma ia palapala, "Methotrexate" ua kuai lilo aku i ehiku huewai o ka 5, 10, 50 ml. Ma ka pepa pahu piha hoʻokahi hue.

Nāʻikepili no ka loaa ana "methotrexate"

Nāʻikepili no ka hoʻohanaʻana i ka lāʻau o loa kekahi, mahope mai o kona papa kuhikuhiE manao - ka kaua e ku e hikoko. ? Aeiiaiaiaaia e lawe "Methotrexate" ma ka hihia ma ka hoʻomanawanui ua loaa mai ka huʻi lymphoblastic leukemia a me lymphomas nehodzhinskimi. No hoi, ka mea, ua hoakaka no ka trophoblast hikoko Fish mycosis a me ka psoriasis (ma ka loa kahua o ka hoʻonaʻauao).

No hoi, ina e ole i'ē aʻe therapies a me ka ai 'he appreciable hopena noi "MTX" no rheumatoid arthritis. Waikiki rheumatologists akamai ma na laauʻano maikaʻi.

Nāʻikepili no ka hiki aku o "Methotrexate Ebewe" i kekahi mau mea nui. Hoʻomalu i koi 'ia ka wā o ka hoʻomanawanui malignancies likeʻole nenoai a me nā loko: akemāmā Ka maʻi' aʻai a me ka umauma Ka maʻi 'aʻai, osteosarcoma a me ka palupalu'aʻaʻa sarcomas, testicular a me ovarian hikoko, Kaposi Jung, retinoblastoma a me autoimmune maʻi.

Owai la ka mea e ole lawe i ka lapaʻauʻia?

He unacceptable e lawe i ka lāʻau a hiki i kanaka me ka hypersensitivity i ka papa kuhikuhiEʻeleu 'Oponopono. Contraindicated? Eaia "methotrexate" hapai keiki o na wahine a me ka waiu, mums. Ole prescribers me nei deviations o ke ake, a konāhua, hematological kāna hana ano (anaemia, thrombocytopenia, leukopenia). He mea hiki ole, e hoʻomaka i ka iapaau ana ka lapaʻauʻia i nā mea maʻi i loko o ka huʻi pae o kekahi infectious mai,'ōnaehana paleʻea deficiency maʻi pale sufferers. E like me ka mea Lūkini like paha, a me ka mea mua "Methotrexate" (Austria) ua ole ae, e haawi aku i kā lākou mau keiki i ka makahiki ekolu.

I ka ua haawiia mai i ka helu o nā maʻi lāʻau me ka nui mālama nui. Mau pilikia nā 'ōpū ulcers a me 12 duodenal ulcer, ulcerative colitis, a me ka dehydration. I mea hoʻomaʻi, hoi pono fungal a me ka mea koʻohune nā mea palahēhē e hana loa cautiously. I keia hui e pili ana nīnūnē ma mua radiotherapy paha chemotherapy.

Hikiʻaoʻao waiwai

"Methotrexate" i loko o ampoules, na papa, ka wā infusions hiki i ka helu o kaʻaoʻao loa. Muli o kona kulana hoʻoponopono pilikia e ala mai mai hematopoietic'ōnaehana (leukopenia, thrombocytopenia, a no laila, ma luna o. P.) A gastrointestinal (dyspepsia, anorexia, ake kaʻawahia, pancreatitis). ʻO ko mākou hopohopo'ōnaehana ke pane i headaches, drowsiness, paresis, ke kāʻili 'ana. High nā māhele o ka lāʻau ke kāhea i ka hooulu ana o ka encephalopathy. Deviations mai o ka pilikia makapō nā loko, a me ka mea'ōnaehana mānowai koko nenoaia (hypotension, pericardial effusion, thromboembolism).

E hoʻoikaika i naehana hanu ole, maʻi obstructive pulmonary maʻi, pokole o ka hanu, maloo, nonproductive cough, kuni. Me ka genitourinary nenoaiu, he mea i ka pilikia o ka loa hakuʻala maʻi a me nā konāhua ole. Hiki hoʻohuikau o spermatogenesis a me ka oogenesis, ua hoʻemi libido, infertility, impotence.

Inā he wahine mea hapai, "Methotrexate" (injections, papa, drip) hiki i miscarriage, malformations a fetal make.

papa dosing regimen

Ma ka iapaau ana o malignant neoplasms regimen o huaale pākahi 'ia a me ka mea hilinaʻi nui ma luna o nā kau huakai kaapuni chemotherapy. I ka wa e hele mai ai i ke noi ana o ka medicament "MTX" no ka rheumatoid arthritis (hoʻomanawanui pane i maikaʻi ano), i ka loiloi mua mahele lāʻau mea nō kāu 7,5 mg hookahi o ka hebedoma. 'Oe ke lawe i ka mahele lāʻau a pau ma kahi hoʻokahi, a me oe e mahele ia i loko o 3 nā māhele i 12 holaʻanuʻu.

Ma kekahi mau manawa (e hoʻokō i kekahi e pono ai ia) i ke hoomahuahua ia pule mahele lāʻau. Naʻe, ka mea e ole mamua o 20 mg. A hiki aku i ka makemake lapaʻau ia ua kō, ka laʻau heluna E e ke kiʻekiʻe o hoemi i ka palena iki. Ka e pono ai lōʻihi like 'ole o ka lapaʻau papa ua ole clinically diagnosed.

Injections o "methotrexate"

A pehea hana i ka ka pahu kui me ka lāʻau "Methotrexate"? Injections no rheumatoid arthritis e hoʻomaka ana e hana i ka laʻau heluna o 7,5 mg no hebedoma. Ua hiki ke hana subcutaneously, intramuscularly paha intravenously. Inā ka lāʻau Ua maikaʻi tolerated ma ka hoomanawanui, ma ka mahele lāʻau hiki ke i nā mahuahua pule ma 2,5 mg akā,ʻaʻole oi aku mamua o 25 mg. A hiki i ka pākōlea hopena ua hiki (IeAUPIIe, IAa IO 1-2 mahina ma hope o he lālā o ka lapaau), i ka mahele lāʻau E e ke kiʻekiʻe o hoemi i ka palena iki pono. No kēlā me kēia hoomanawanui me ka rheumatoid arthritis, laʻau heluna i ke i nā like no e pono ai ke kanawai o ka iapaau ana. Lapaʻau haʻawina Ua hōʻike i "Methotrexate" maikaʻi ke kemu, a haawi ka palena haʻahaʻaʻaoʻao pane, ina o ka ka pahu kui subcutaneously paha intramuscularly.

Me ka mea ana? Eaia o "methotrexate" ka loiloi mua maikaʻi pākōlea hopena pilikia no elua makahiki. Inā 'oe ana rheumatoid arthritis lāʻau mai i kanawai i ka 3-6 pule.

Excessive nā māhele

Excessive nā māhele Russian medicament a me ka lāʻau "Methotrexate Ebewe" (na papa, injections, infusions) ua i hōʻike 'ia kekahi manaʻo symptoms. overdose mea hiki e pae methotrexate lehulehu i loko o ke koko wai koko.

Lapaʻau Ua koke (optimally i loko o ka hora mua) o antidote palapala noi, i mea ka kalipuna folinate. pono e like no a oi aku ma mua o ka mahele lāʻau loaa "methotrexate" Ka buke o ka injectate. Additional nā māhele o ka kalipuna folinate i ke koi 'ia e ke kauka i pono ai. Mua oe kāhuakomo i kēlā me kēia hope mahele lāʻau, a laila,ʻo kēlā kanaka 6 hola ma ke kaʻina hana, e hoʻopau i nā symptoms o ka overdose o ka hoʻohana antidote mea pono e hooholo i ka pH o ka mimi. Ia ana e kń i ka likelihood o ka ulu nephropathy.

¶ A i loko o ka AEeAaOA o ka ana pono, e hoʻopau i ka hopena o ka overdose o ka lapaʻauʻia ka loaʻa o hydration a me ka mimi alkalinization. e hoolalelale i kēia mau kaʻina hana i ka excretion o methotrexate.

AaOIeIOUIeXAOAaIN a me nā waiwai a me ka hoʻomākaukau

Inā he hoomanawanui i gout, a me ka manawa i oleloia o "Methotrexate" lapaau a "Methotrexate Ebewe" mahele lāʻau arthrifuge ai 'e e? Ee. Concurrent hoʻohana 'ana o nā salicylates, phenylbutazone, fenitoiona, sulfonamides, he helu o kekahi antibiotics (tetracycline, penicillin, chloramphenicol), anticoagulantsʻauhau'ēʻaʻe keia a me hypolipidemic laau ke alakai i ka loa kaʻawahia, a hiki i ka make.

Nui dala o ka "methotrexate" ma laua me NSAIDs hiki i ka make mai ka loa a me ka hematologic gastrointestinal kaʻawahia. Ke me ka hui pu ana o NSAIDs a me ka haʻahaʻa-mahele lāʻau lapaʻauʻia ma mua o kākou e emi i ka excretion o ka weuweu ma keʻaʻa puʻuwai tubules.

Hepatotoxic ai '(nānā' ana i sulfasalazine, azathioprine, ethanol) e hoomahuahua i ka pilikia o ka hepatotoxicity, gematotoksicheskim - gematotoksichnosti "methotrexate". Concurrent noi o ka lāʻau a me ka pāhawewe Inc'āpana hana e hiki i iwi lolo kaumaha.

Special ao

Mua oe hoʻomaka lapaʻau ka lapaʻauʻia "Methotrexate" (ka pahu kui, ina pono huaale - 'aʻole i mea), ia mea pono e hoʻomaka i ka piha koko helu (e ike i ke kiʻekiʻe o nā platelets), biochemistry (e ho oholo i ka aiee o ke akepaa nā'ūhū, albumin, bilirubin), hana umauma X-Ray. Eia hou kekahi, ia mea e pono e nana i nā puʻupaʻa, ma kekahi hihia,ʻaʻole e hana wale ho'āʻo no ka hepatitis a me ka tuberculosis.

I mea,ʻaʻole e hala kekahi manawa o ka intoxication, ia mea e pono ai i kū i ka haku mele 'ana o ka meaʻike ākea koko (helu o leukocytes a me platelets),ʻaʻa puʻuwai hana, hepatic transaminase haʻawina, kiʻekiʻe o uricʻakika ma ka lāʻau lapaʻau. Ma mua o kela a me keia ano o ka "methotrexate" ku una mucosa a me ka pharynx E ke kulana kupono no ke alo o ka ulcers. Ke kaʻina hana o ka iwi lolo hematopoiesis E ke kulana kupono i ka hoʻomaka o ka Inc, hookahi i ka lapaau, a ma hope o kona panina.

kuai laulā

hookuu aku oia i palapala (papa, ka pahu kui) a me ka mahele lāʻau - ke kumu nui aʻe ka heluna i ka waiwai e lilo aku ana o "Methotrexate" lāʻau.

Price'ōpala o ka papa (50 pcs.) Me he 2,5 mg mahele lāʻau i ka ÷ 240 a hiki i 250 rubles. Ka hookahi dala o ka 5 mg mahele lāʻau papa hiki ke kuai ia no ka nui o ka 390 a hiki i 420 rubles. 'ōpala i ka lāʻau a me ka mea kiekie loa mahele lāʻau (10 mg) e loaʻa 530-550 rubles.

Ke kākoʻo pāʻoihana no ka pahu kui mea nui hou pipiʻi, a me ke kumu kuai hoolaha aku ka nui lehulehu. No ka laʻana, 5 ampoules medicament me ka laʻau heluna o 50 mg / 5 ml i loko o kekahi keʻena kūʻai lāʻau lapaʻau hiki ke loaʻa ma kahi o 1200-1300 rubles, oiai kekahi poe - 4900 rubles.

consumer manao

Aia nō nā maikaʻi a me ka hopena maikaʻi 'ike o nā mea maʻi e pili ana i na laau "Methotrexate". Ma rheumatoid arthritis, nā hōʻike manaʻo ka hapanui hoʻopaʻa i ka maikaʻi nā mea kū (ma kahi o 80% o nā mea maʻi ua hoano e hopenaʻoi loa i loko o ka 1-1.5 mahina mua o ka nohoʻana). Eia naʻe, i kekahi hiki pinepine lohe e pili ana i ka hopena maikaʻi 'ole o ka lāʻau ma ka hoomanawanui, ma ka ulu o kaʻaoʻao' ole o ka loli iki ana oolea ma ka aoao o kekahi mau nenoai a me nā loko.

E loa kń i ka hopena maikaʻi 'ole, "Methotrexate" E e hoonoho wale n? E ka hele kahuna lapaau, a ua hoopakele mai no hoi oia, e kūkulu i ka lapaau kumumanao, a koho i ka hoʻokō mahele lāʻau.