'O nā pāpuni "Pyrazinamide" he hopena bactericidal a i'ole ka bacteria-anti-tuberculosis ma muli o ke kukū. Ho'oikaika'ia ka hana o ka lā'au lapa'au ma lalo wale nō o nā hua'ele'ele (ma ka pH o 5.6 a me lalo). Ma ka 'O ka ulu'ana o ke kū'ē'ana, hiki ke kūpono i ka ho'ohana'ana i nā lā'au lapa'au me nā mea hana'ē a'e, he hiki ke ho'omākaukau i ka lā'au lapa'au. 'O ka lā'au lā'au "Pyrazinamide" ('o ke a'o'ana no ka ho'ohana'ana i ka hō'oia'ana i kēia) he mea nui loa ia i ke kāpikupiki e ho'opō'ino ai, i'ike mua'ia, ma nā'ano o ka'ano pneumonic, ka tuberclomaloma, a me ka lymphadenitis. 'O ka lā'au lapa'au e ho'oha'aha'a i ka lawe'ana o ka urate a me ka waikawa uric, hiki ke ho'onāuki i ka hyperglycemia. 'O ka lā'au lapa'au mai ka'ōpala pā'ani ka aneane a piha a ma'alahi. Me nā pāpona plasma, pa'a ka lā'au lapa'au i 10-20%. Ma hope o ho'okahi hola a'elua paha, e mālama'ia ka māhele ki'eki'e o ka lā'au lapa'au. Ho'omaopopo pono'ia ka lā'au i waena o nā wai a me nā mea i ho'opa'a'ia, ua waiho'ia i loko o nā'ōpili, e like me nā lunamāmā, nā ate, nā pu'upa'a, a me nā'āpana'epau o ka lepera. Kuhi ka hua i ka BBB. Ke kau'ia ka mīkini i loko o ke ake.
Hō'ike
'O ka lā'au lapa'au "Pyrazinamide" (nā hō'ike a nā luna'ono e hō'oia i kēia)'o ia ke koho mua loa i ka mālama'ana i ka ma'i.
Ho'oponopono i nā kaulike
Ua ho'okumu'ia he lawa'ole ka monotherapy. I ka pili ana i kēia, ua'ōlelo'ia ka lā'au "Pyrazinamide" no ka ho'ohana'ana me nā lā'au'ē a'e me ka hana'ākope-tuberculosis. No nā po'e mākua, 30-35 mg / kg i kēlā me kēia lā. No nā po'e ma'i i'oi'ole ke kaumaha ma mua o 50 mau kilokilo, ua like kēia helu i'ekolu papa (1.5 g). I ke kaumaha o ka'oi aku o 50 kg e lawe i ka 4 pa. (2 g). No nā'ōpiopio,'o ka helu kaulike he 2 grams. Lawe'ia ka lā'au lapa'au me ka mea'ai. Pono'ia e inu i nā lā'au la'au i ka wā kakahiaka.
'O ia'o "Pyrazinamide". Nā kuhikuhi no ka ho'ohana. Nā kuhikuhi kūikawā
'A'ole ke kumu lā'au e ho'oulu i ka loiloi inā mālama'ia ke kākau'ana o ke kauka. I ka wā e lawe ai i ka lā'au lapa'au he nui, loa'a nā hopena maika'i'ole mai ka'ōpena o nā'ōpū waena - ka'ākau, nā maka'āinana a me nā mea'ē a'e. Aia kahi ma'i ma ke akepaʻa, paha dyspepsia. Ho'i'ia ka hō'ike'ana i nā lā'au hō'ailona. Mua a i TB lapaʻau i loko o nā mea maʻi no 60 makahiki ua lawe mai malama ka mālamaʻana o nā hoailona o ka bilirubin, AST, uricʻakika a me ka Alt. I nā ma'i o ka hana ate, pono ka wehe'ana i ka lā'au. Hiki i nā ma'i ma'i ke ho'omohala i ka hypoglycemia. I ka hui'ana me ka lā'au "Rifampicin" hiki ke ho'omaopopo'ia he kīpīpī. I loko o ka ma'alahi o ke noi me ka Probenecid lā'au lapa'au, hiki i ka emi'ana o ka excretion ma muli o ka hopena o ka ho'onāukiuki. Hiki paha ke ho'ohana i nā lā'au "Isoniazid", "Ethionamide",'eleka o ka nicotine a me nā'ano'ē a'e e like me ke'ano'ano like'ole. 'O ke lā'au lā'au "Pyrazinamide" (a'o no ka ho'ohana'ana i ka hō'oia e hō'oia i kēia) maika'i ia no nā makahiki'elima. E kū'ai i ka lā'au lā'au i loko o nā pahu kopa, ma nā wahi i pale'ia mai ka mālamalama.