Ua aneane elua-hapakolu o ka maʻi 'aʻai hihia i kauoha ae la ia e huikau ka "hewa" ma ka DNA

Cancer triggered ma ka wahaheʻe i loko o ka DNA, a me ka hou study ua loaʻa i loko o ka hapanui o na hihia o ka hanana o Ka maʻi 'aʻai, mau hewa i loa huikau. Ka mea, i ole, kena ae la ia e aaiaoe predisposition a? Aneie aʻe, a me ka hopena o ka huikau ka hoʻolako 'ole.

Ke ao nei i ka hewa a me mutations he hoʻonui i ka hooulu ana o oncological hikoko, no ka mea, he wahi DNA hewa e alakai ai i ka mea i keena, e hoʻonui uncontrollably.

ʻepekema,ʻo kēia mau mea mutations i Iosia iʻano nui ma nā mea a pau: i kekahi i kekahi mutation i ka aaiaoe kumu, a me ka mea hoi, kena ae la ia e mawaho aʻe, a hiki pōʻino DNA, e like me ka uahi paka a me ultraviolet hawewepoko.

Akā, i ke kolu o ka mea moe ma ka kaulele hewa. Ke hou scientific hoike paʻiʻia i loko o ka puke pai Science, hoʻopaʻapaʻa i keia ololi maoli ka elua-hapakolu o kēia mau mutations. I ka wā o ka halepaahao i hookaawale, ia kope kona DNA. No laila, i kēlā hou aeea e i kona mana iho o ka aaiaoe mea. Akā,ʻo kēlā manawa, aia no he kope, ka mea i hiki no ka hope hewa. Ma kekahi mau hihia, i kēia mau hewa ke alakai i ka maʻi 'aʻai.

noiʻiʻepekema

"Haʻawina Ua hōʻike i ka maʻi 'aʻai, e hoʻomōhala i loko o ke kino, nānā' ole o ka ona o ka 'ia", - wahi a papa kiʻekiʻe kanaka noiʻi Dr. Bert Vogelstein, he pathologist Center luna' lapaʻau Sidney Kimmel Cancer ma Dzhona Hopkinsa University.

New scientific noiʻiʻepekema AIM e hoʻomaulia ka pakeneka o ka maʻi 'aʻai hihia i ke kumu ma ka hereditary aʻe, ka' āina a me ka huikau ka hewa. ʻepekema, ua ulu ka makemakika kükohu i nāʻikepili mai na? Aaeno? O Ka maʻi 'aʻai hoʻomanawanui iki mai a puni ka honua, e like me ka pono me nā hoailona o ka DNA sequencing.

kaulele hewa

Ka like paipai ia ma kahi o 66% o ka maʻi 'aʻai i kena e huikau ka hewa 29% o ka maʻi' aʻai i triggered e? Aneie aʻe paha ka hewa ala o ke ola. A wale 5% o ka hihia o Ka maʻi 'aʻai, he ke kāhea heritable mutations.

Ke noiʻi e hoailona oukou i keia helu loli aʻe i kekahi mau mea, mai ka poe mai o nā kānakaʻepekema i aʻo Ka maʻi 'aʻai. No ka laʻana, UK noiʻi kookoo e olelo aku nei i ka 42% o ka maʻi 'aʻai hiki ke hooki ia e hoʻololi i ka I Aloha Hawaii o nā mea maʻi.

Ma ka scientific pepa hoʻopaʻapaʻa ana kekahi mau ano o ka maʻi 'aʻai, no kekahi laʻana, e like me lolo hikoko, a prostate kokoke loa wehewehe e huikau ka hewa. ʻepekema, ua 'ike akula i huikau ka hewa, kena ae la oi ma mua o 95% o nā hihia i i ua noʻonoʻo ma ka noiʻi.

Kimia like kiʻi

Ma kekahi o nā kiʻi noiʻi hoʻohanaʻulaʻula ke kala, e hōʻike i ka pakeneka o cancerous lesions i loko o nā wāhine. Maʻi wahi i ili mutations ma kaʻaoʻao hema i ke aupuni '. Na mea i huiia me ka huikau ka wahaheʻe - i loko o ka-oaio? A, a ia? Aneie aʻe - ma kaʻaoʻao'ākau.

No kela a me keia ano poe hui, pakeneka i pili i ka kekahi ololi, mai keʻokeʻo (0%) i kaʻulaʻula (100%).

Ka maʻi 'aʻai i hōʻike' ia:

• B - i ka lolo.
• BL - bladder.
• Br - umauma.
• C - cervical.
• Kr - colorectal.
• E - esophagus.
• HN - poo a me ka ai.
• K - mohala.
• Lee - ke akepaʻa.
• LK - leukemia.
• Lou - malamalama.
• M - melanoma.
• NHL - 'ole-Hodgkin ka lymphoma.
• O - ovarian.
• P - pancreas.
• S -'ōpū.
• TH - ka thyroid gland.
• U - uterus.

Ke ole o ka mawaho aʻe

E like me ka hopena o ka hana o nā kānakaʻepekema, no kekahi maʻi 'aʻai pāʻani? Aneie aʻe i ke kūlana nui. No ka laʻana, i ka hopena maikaʻi 'ole o ke kaiapuni, kuhikuhi pūnuku puhi kena ae 65% o nā mea a pau akemāmā Ka maʻi' aʻai hihia. I ka noiʻi i loaʻa ia wale 35% o ka akemāmā Ka maʻi 'aʻai hihia i kauoha ae la ia e huikau ka hewa.

"Ka wale mutation i loko o ka halepaahao meaʻaʻole paha ia i Ka maʻi 'aʻai," - wahi a Vogelstein, e olelo ana me ka' epekema lono i hoomakaukau ia e John Hopkins. "Akā, i ka nui he mea he mutation, ka mea i oi aku ka likelihood i ka halepaahao, e lilo malignant," - wahi a ke akamai.

I ka hoʻohuiʻia o ka DNA hewa, a mawaho aʻe

"Penei, mutations mai ka huikau ka hewa lawa ia i Ka maʻi 'aʻai, a hoʻomōhala ai ia ia iho i loko o kekahi mau hihia a", - wahi a Vogelstein. Akā, e like me ke nä känaka 'epekema, i loko o nā hihia, he huihui' ana o ka huikau ka hewa e like me ka wahaheʻe, kena ae la ia e? Aneie aʻe, ultimately alakai e,? A? Ka maʻi 'aʻai. No ka laʻana, ili aeee i ka kumukahua mutation ku i ka huikau ka hewa a me ka waiū i ultraviolet malamalama. "Ia aʻe ana ke hooloihi i oi mutations e alakai i ka maʻi 'aʻai," - wahi a Vogelstein.

Ekolu kumu mutations ma ke kelepona hele kiʻekiʻe

Christian Tomasetti, hui pu Kumu o Biostatistics ma Johns Hopkins, i olelo ia ekolu kumu mutations ma luna o ka hana o ka hanana o misprints, loaʻa i ka wā hoʻohana 'ana i ka eeaaeaoo. Kekahi o kēia mau errata i ia i ka hopena o ka luhi a me ka hihia typists. Ka mea, hiki ke noʻonoʻo me? Aneie aʻe. "A ina ma ka eeaaeaoo? E hoʻohana i ka typist, aole hoi he ki, keia hereditary ololi" - Tomasitti mai nei i loko o kona hoike.

"Akā, i loko o ka maikaʻi 'ia, ma ka typist mea pono hoʻomaha ihola, a ua hoʻohana i ka eeaaeaoo hana maikai, typos e no e" - ia wahi. A ka mea, o ka kaulele hewa.

He aha e hana ana i ka noiʻi no ka Kāohi o

Aia i kekahi papa kōnane o pale maʻi 'aʻai, kena ae la ia e? Aneie aʻe a aaiaoe aʻe. E kōkua emi i ka pilikia o ka akemāmā Ka maʻi 'aʻai, i ka puhi paka ke pakele, a me ka wahine ka mea i diagnosed me ka umauma Ka maʻi' aʻai, e, Kamuela i prophylactic mastectomy.

E like me ka noiʻi, e manaoia mau iniiaiie Kāohi papa kōnane o ka pono ala e ho'ēmi i make mai ka maʻi 'aʻai. Nā kākau e hoailona oukou i keia mea,ʻaʻole e hiki i ka iniiaiie Kāohiʻana o ka maʻi 'aʻai mai, kena ae la ia e huikau ka mutations, akā nō haumāna Kāohi ke kōkua hoola i ka hoʻomanawanui ka ola.

E like me ke ao, haumāna Kāohi pili ia i ke kakahiaka nui ka loaʻaʻana o ka maʻi 'aʻai. "E Pono e kālele ana ma luna o kakahiaka ka loaʻaʻana, no ka mea, ke kaʻina mea,ʻaʻole he mutation e hiki ke käpae '," - ke i mai nei i loko o ka palapala hoike Tomasitti.