"Valsartan": olelo ao no ka hoʻohana. Medicine "Valsartan" - analogues a me nā hōʻike manaʻo

Ka lāʻau 'Ua kapaia "Valsartan" manual wehewehe like hui kumu, komo pū i loko o pharmacological pūʻuluʻike ākea vasodilators type. I ka hana o keia k mai i ka haʻi hypertensive ia ma luna o ka hoʻomanawanui. Nō hoʻi, i kēia k i kekahi e wae antagonistic ia ma luna o ka I ₁ receptors i nā kuleana no ka hoʻokō 'ana o ke kaʻina hana o ka angiotensin II. Eia hou, ke ano diuretic ole ke i ma luna o ke kanaka kino o ka hoʻohui pūʻia mea paahana, e like me "Valsartan". Analogs o keia la hoomalolo - mea hōʻikeʻikeʻuʻuku "Diovan" "Exforge" "Tantordio" a me ka "Valsakor" - i like waiwai.

Hiʻona o ka pharmacological 'ana

Like no ka hiʻona o ka pharmacological hana o antihypertensive Luna, ia mea, yavlyas kekahi hoa ai-kapa angiotensin II mea loaʻa, ka pono ka paleʻana i ka I ₁ receptors a maoli he i ka wai koko lehulehu o angiotensin II. Ma ka Ia lapaau "Valsartan" (kuhi no ka hoʻohana wehewehe kona haku mele 'ana)' aʻole i inhibit angiotensin-hoʻololi ''ūhū. No hoi, ka mea, 'aʻole i loaʻa i kekahi agonist hanana hulina me ka pili ana i ka MA ₁ -receptors. I waena o nā mea a pau, ka mua "Valsartan" 'aʻole i aeie i ka ion auwai a me receptors o nā hormones mea e nui no ka mea maʻamau rula o ka mea'ōnaehana mānowai koko nenoaiu. Eia hou, i ka lāʻau i ole ia ma luna o kaʻilikai tireoglobulinpa, uricʻakika, huina naʻokoko a me ka wai koko monakō koko.

Pharmacokinetics

Inā mākou e kamailio e pili ana i na pharmacokinetics o ka Anati-hypertensive konohiki, e like me ka laau no "Valsartan", laila, e like me ka rula, ka mea, ua nui hoʻomaka koke ke kemu, mai ka gastrointestinal'āpana ma hope o ku una hooponopono, eia nae ke degere o ka omo hilinaʻi nui ma luna o kanakaʻokoʻa.

Ma keia antihypertensive hookoia ana hoʻomaka e ana ma hope o ka haneri - hoʻokahi haneri a me ka iwakālua minuke ma hope o ka hookahi dosing o ka lāʻau, a ua loaʻa i kā mākou pākōlea hopena ma awelika no ka eha - hola eono. Ke loa bioavailability o keia k ka pono ma luna o 22%. I huli ai oe, paa ana i ke koko nā polokina (ʻano nui albumin) o 94-98%. I ka wai kokoʻae o ka lāʻau "Valsartan", a me nā hale i ka pololei ole ma ia, mea e pili ana 2 L / h. Ua Ua hōʻike antihypertensive Agenaʻano nui i loko o ka faeces (ma kahi o 70%) a, a hiki i ka nui uuku loa me ka mimi. Ke Hookah kekahi Pono nń ia i loko o ka hihia o ka iaʻi o ka bile ducts a biliary cirrhosis, keia k AUC piʻina ma ka awelika ma ka hapalua. Ia makahiki, ka hoʻohana 'ana o ka ai' o kekahi loli ma ka pharmacokinetic waiwai a me nā mea kiko'î a malama.

Description o ka lāʻau

Hua mai la i antihypertensive lāʻau "Valsartan" (kauoha no ka hoʻohana ana i ua koi 'ia ua komo i loko o kēlā me kēia pack) i loko o ka palapala o ka papa, ho film-lole komoʻuʻuku nona, a ma ke ano o ke keʻokeʻo he lepo lā. Kēia waiwai i kokoke insoluble i ka ano o ka wai a me ka hooholo koke wailana ma ka metanola a me ka ethanol. Ke hakakino kaupaona ana o keia hoʻomanaʻo mea e pili ana i 430-435. Like no ka haku mele 'ana o kēia meakino-vasodilating, laila, e like me ka papa kuhikuhi pae'ōnaehana hehee wale ka mea, loaʻa he angiotensin II mea loaʻa' ano a me ka thiazide diuretic.

Kahua ka lapaʻauʻia hoʻohana

E lawe i ka Akala a "Valsartan" kauoha no ka hoʻohana meaʻano nui e waiho i kauwahi o ka ai-kapaia hoʻohui pū Inc na kanaka e hana eha iaʻi mai ka maʻi naʻau ole paha hypertension.

Eia kekahi, ua kahaki ii ka antihypertensive Agena hoʻohana i ka hōʻoi 'ola i ke kai o ke kanaka me ka huʻi myocardial infarction (me ka huikau ventricular systolic dysfunction a hema ventricular ole). E hoomanawanui i ka poe i lawe kuʻuna ai 'me ka naau maʻi, diuretics i kekahiʻano pinepine lawelawe i ka lapaʻauʻia "Valsartan". Analogues o keia mea paahana hiki ke hoʻohana pū i loko o nā mea a pau o ka luna hihia.

laʻau heluna

E lawe i ka antihypertensive lāʻau, kauka pele waiho aku i kekahi a me nā manawa i ka lā i kanawalu paha he kanaha milligrams, niioaaonoaaiii. I ka wa e kaawale aku o ka mea i makemake pākōlea hookoia, hiki e hoonuiia ka kela la i keia laʻau heluna. Naʻe, i kēia E e hana i nā a wale i hoakaka ia ma kekahi kauka. ʻO kā mākou mahele lāʻau o ka mea ia lāʻau i nā kānakaʻekolu haneri a me ka iwakālua milligrams.

Ka papa inoa o nā contraindications i ka hoʻohana 'ana o

E hoʻohana i ka hoʻopololei-vasodilator poe akamai i ikaika waiho aku ia ina he mea kekahi kanaka o ke kanaka hypersensitivity a hiki i kekahi o kona eiiiiiaiou. I ka hoʻouka kekahi allergic reactions analogously E hoomanawanui mai ka lawe ana o na papa io "Valsartan". E hoi mai e lawe ia e hoʻomanawanui iki mai ka poe i ole hiki aku i ka makahiki o ka umikumamawalu ka mua lāʻau. Ka hope, ua ku pono ia i ka mea i ua ole maopopo maopopo i ka maluhia o ka pono o ka antihypertensive ai 'i loko o ia hihia.

E hoʻohana i hāpai keiki

Hoakaka ia ka lāʻau "Valsartan" na wahine i hanau i ke keiki, loa contraindicated. Mau hoʻonohonoho 'inikua haʻawina hōʻike i ka' ano kiʻekiʻe kamepiula o adverse hopena o antihypertensive Luna ma ka fetus. Eia naʻe, ma ka hihia o ka loa ola-hooweliweli maʻi i loko o a he mea hiki ole i ka hoʻohana 'ē aʻe, i pakele laau lapaau, a me ka mea i emi kona mana, noi o ka lāʻau-vasodilator. Kaawale E e olelo mai e pili ana i ka inadmissibility o ka pono o ke koʻi, oiai hanai ana i ke keiki kamaiki me ka umauma o ka waiu.

Hikiʻaoʻao reactions

Ke kauoha o ia i kekahi lāʻau 'antihypertensive, like "Valsartan" hiki i ka helehelena o keʻano loa headaches, pōniuniu, cough a me ka nawaliwali. Eia hou kekahi, he mea pinepine nausea, diarrhea, hyperkalemia, syncope, a me ka Kanikani'āʻula. Abdominal eha, vertigo, neutropenia, thrombocytopenia, arthralgia, hoʻi eha, myalgia, luhi, a me ka nani e hana ana i ka hopena o ke ano like lāʻau aaieieno? "Valsartan". ka mea, ua mua i hoʻohana Reviews o ka hoʻomanawanui iki mai ia, i hoike pilikia no ka pharyngitis, rhinitis, sinusitis, heʻano o ka mea hoʻomaʻi nā mea palahēhē a me nā mea palahēhē ka heluna i ka luna naehana Oihana. Eia hou kekahi, he nui loa kanaka i malama hyperbilirubinemia, ua hoʻemi hematocrit, hypercreatininemia, mea ulu i loko o ke koko urea naikokene maʻiʻo, a me ka emi ana ma ka hemoglobin. Eia hou, oe e hoomanao mau ana ka i ka wā hoʻokahi? Eaia o nāʻano-vasodilator "Valsartan" a me na laau, mai ka pae ana o potasiuma-loa lakou e minamina diuretics hiki i hyperkalemia ulu. Ma ka hihia o ka lāʻau overdose e hana aku ana e like me bradycardia, hypotension paha tachycardia.

XIX. kaiapuni

Ma ka hopena, ka mea pono e olelo mai ana ia mea e pono ai me ka lōʻihi mālama nui, a ma lalo wale ikaika 'inikua hooponopono hoonoho i? Eaia o ka antihypertensive Agena i loko o nā mea maʻi me ka paʻakai deficiency, hanahana loa kue o ka hakuʻala,ʻeluaʻaoʻao stenosis o ka ai-kapaiaʻaʻa puʻuwai artery a me ka na hiohiona ka ho'ēmiʻana i ka ai hoʻolahaʻia ke koko buke. O ke kumu ho kuhikuhi i ke kiʻekiʻe-kamepiula nā mea maʻi me ka arterial hypotension. Eia hou, oe e uku kuikawa noonoo i kanaka e loaa ana mai ka biliary cirrhosis ole loa kāna hana o ke akepaʻa. Nā mea maʻi a me kaʻaʻa puʻuwai artery stenosis pono a eia i ka mālamaʻana o nā nā hoʻohui like o ka urea naikokene a me ka lāʻau lapaʻau creatinine. Nō hoʻi, nānā 'ia iho e noi mai ana nā mea maʻi me ka iaʻi o ka biliary'āpana, e loaa ana potasiuma-loa lakou e minamina diuretics, kūikawā kalisodergaszczye potasiuma pakuʻi ai paha ai'. Eia hoi, pono e hoʻohana 'lōʻihi mālama nui antihypertensive lāʻau "Valsartan" kanaka nona ka hana a ua pili i ka holoʻana o kekahi kaa, a me ka poe nona ka hana e pono mau' me ka lehulehu kiʻekiʻe o ka noonoo.