"Amphotericin B": aʻo, keʻano papa hana o ka hana. Hoike e pili ana i ka lāʻau '

Fungal ili lawe nui discomfort i ka hoʻomanawanui. A, ua infectious maʻi. Nolaila, i ka wa a ka mua hoailona o ka fungus pono pono hoʻohuli i ka hoʻomalu. I ka halaʻana o ka 'inikua ho'āʻo a me nā examinations ke kauka ua koiia e koho i ka hoʻomanawanui pono ka ai'.

Loa pinepine, no ka iapaau ana o fungal mai ka hoʻohana i kekahiʻano o ka hinu a me huaale. Eia naʻe, ka hapanui kauka e olelo aku ia ia he pathological ana ua maikaʻi loa ia e intravenous ka pahu kui. Ma hope o injections o ka lāʻau koke hoomaka i ka hana ma luna o microorganisms e ho'āʻo i kekahi pā lonoaʻili no ia.

Ka loa efficient pono a me ka aoao, e lawe aku i ka lapaʻauʻia, e hoʻopau fungal maʻi "Amphotericin B". Na Ke Kumu, ano o ke kalaʻana aku a me ka hoike e pili ana i ka lāʻau e hōʻike mai iā ia ma lalo nei.

Palapala, haku mele 'ana, hōʻikeʻano a me ka'ōpala o ka antibiotic

E hoʻomaopopo mai noʻonoʻo i ka lāʻau hiki ia i loko o ka kēia mau 'ano apau loa.

• Lyophilisate "Amphotericin B". Reviews Ua hōʻike i kēiaʻano o ka lāʻau mea he porous hygroscopic nui o melemele ano me ka ole hai ala. Ua ua papahana no ka makaukau o ka infusion pāʻoihana. Kaʻeleu ke keʻena o ka lāʻau mea amphotericin B. ka eiiiiiaiou e hoʻohana i kākoʻo 'ona e like me monobasic paʻakai posapahate a me deoxycholicʻakika. Ma ke kuai ana o ka medicament ua lako i ehiku huewai o 10 ml, a me ka pepa cartons.

• Hamo Cuticura "Amphotericin B". Noi ana i keia mea ua hoikeia mai me he kula hope lāʻau ma ka hui pu ana, Inc. Antifungal mea poni i hoʻohana wale externally. He melemele, a iloko ona i kakauia me kaʻeleu 'Oponopono o ka ia inoa. Like no ka mea hou eiiiiiaiou e e hoʻohana i mea pōhaku aila, petrolatum, a me ka polysorbate 80. Buy keia ka lapaʻauʻia hiki ia i loko o ka pahu o ka 30 paha '15

Keʻano papa hana o ka hana o ka lāʻau protivogribkvogo

He aha mea i ka lāʻau "Amphotericin B"? Na Ke Kumu no ka hoʻohana (o na papa io a me ka mea hana 'Oponopono loaʻa nō problematic) ai ia mau moʻolelo i mea mea he macrocyclic polyene antibiotic me antifungal haʻawina. Ua ua hua mai ma Streptomyces nodosus, a ua hoakaka fungistatic a me fungicidal hana (ke kaumaha ma muli o ka lehulehu o ka lāʻau i loko o liluwelo fluids a me susceptibility).

Ma hope iho o ka lāʻau komo i ke koko kahawai ka mea e hoopaa ana i ka sterols mea i loaʻa i loko o ka halepaahao membranes o fungi ikepili koʻikoʻi i ka waiʻona. E like me ka hopena o ia waiū ua nee permeability a me ka wehe intracellular eiiiiiaiou ana i loko o ka extracellular makahiki.

Ka lāʻau 'o "amphotericin B" He hana ku e he nui ke kanana nei, a moderately hana ku e protozoa fungi.

It E e kaulana no hoi ia ma keia mea hoʻopale Fusarium spp. a me Pseudallescheria boydii. Eia hou, keia k mea i mana e ku e ia rickettsiae, koʻohune a me nā mea hoʻomaʻi.

Ke kinetic waiwai o ka lāʻau

Ano, e ike i ka mea me neia he antifungal konohiki, e like me "Amphotericin B". Keʻano papa hana o ka hana ana o keia Agena i, ua ho'ākāka 'ia ma luna.

Ma hope o intravenous hooponopono ana o ka lāʻau i loko o ka hookahi mahele lāʻau i loko o ke koko koke i hana mai i kona pono ka lehulehu i ua malamaia no ma ka lā. C nā polokina e hoopaa ana i ka mea paahana wai koko ma ka 90 pakeneka.

Nānā akula au i medicament māhele ma ke akepaʻa, akemāmā, hakuʻala, spleen, Muscle, adrenal gland a me nā nā loko a me nā'aʻaʻa. Kona lehulehu i loko o pleural effusion, peritoneal a me synovial fluids e like me koʻana koko Quotes kīnā 2/3 o ka lehulehu i loko o ke koko.

Kēia alanui o ia hoʻi, IKE OLE IA. I mimi a me ka bile ma kahi o 98 pakeneka o ka lāʻau makana i loko o ka palapala o metabolites. E hōʻike 'ia lohi ma nā puʻupaʻa. Ka loiloi mua hapa-ola o ka lāʻau i loko o nā mākua, he 24 hola, i loko o nā keiki - 6-40 hola, a me ke keiki - 20-60 hola. Maʻi hapa-ke ola o 15 lā.

nāʻikepili antibiotic

I Hawaii maʻi lapaau "Amphotericin B"? He Ua hoonohoia ma e holumua ai, ola-hoʻoweliweli fungal nā mea palahēhē mea i kena ia e susceptible microorganisms:

• histoplasmosis, hoʻolaha cryptococcosis, coccidioidomycosis;
• cryptococcal meningitis, paracoccidioidomycosis, chromomycosis;
• meningitis kena ae la ia e nā fungi, North American blastomycosis;
• metastatic a me invasive aspergillosis, phycomycosis (zygomycosis);
• hana hoʻolaha candidiasis gialogifomikoza;
• punahelu mycosis, maʻi mycetoma;
• hoʻolaha sporotrichosis, abdominal nā mea palahēhē (me peritonitis);
• endophthalmitis, endocarditis, fungal sepsis;
• Visceral leishmaniasis, fungal urinary'āpana nā mea palahēhē;
• 'Amelika cutaneous visceral leishmaniasis.

Contraindications antifungal Agena

ka moku'āina e pili i ka pāpā lāʻau "Amphotericin B" (o na papa io o ka fungus o ka ia inoa e i hua mai) E hoomanao i. E like me na kuhikuhi, keia mea paahana ua contraindicated:

• maʻiʻaʻa puʻuwai ole;
• ma hypersensitivity;
• i breastfeeding.

Me ka mālamaʻeleu medicament hoʻohana iʻaʻa puʻuwai maʻi (me glomerulonephritis), amyloidosis, ake cirrhosis, hepatitis, anaemia, agranulocytosis, hāpai keiki, a mimikō.

Lyophilisate "Amphotericin B": kauoha no ka hoʻohana

No ka makaukau o ka intravenous ka lapaʻauʻia pāʻoihana i hoʻohana 'ia me ka loiloi mua lehulehu o 5 mg / ml. Ma ka 'ohe 10 ml o sterile wai no ka pahu kui e e i ka hue i ka medicament. Next, kahi naueue ae la e lilo i ka aniani moakaka colloidal loli.

Intravenous lāʻau ua lawelawe i loko o ka hola ma lalo o ka hooponopono ana o ke koko,, kino mahana a me ka naau ana o ka hoʻomanawanui. Ma kona maikaʻi ioeeiiaiey lāʻau i paipai i kela la laʻau heluna o 0.25-0.3 mg no kg kino kaumaha (ke kaumaha ma muli o ka oolea o ka maʻi).

I maʻi o ka naau a me ka ipu koko, mahuahua pā lonoaʻili a me ka lawa hakuʻala hana, lapaʻau ua hoʻomaka 'ia me dosages liʻiliʻi (5-10 mg), a ua i nā mahuahua ma 5-10 mg no ka lā, a ua like ia 0.5-0.7 mg no kg.

Ka wā sporotrichosis papa mahele lāʻau lapaʻauʻia o 2,5 g., A me ka lōʻihi o ka Inc - no ma ka liʻiliʻi 9 months.

I ka wā o ka mea paahana aspergillosis laʻau heluna o 3,6 g., A me ka lōʻihi o ka iapaau ana - ma ka liʻiliʻi loa 11 mahina.

Keiki i ka hoʻomaka o ka Inc lawelawe 0,25 mg no kg kino ke kaupaonaʻana no ka lā, a laila māhuahua i nā i ka i kā mākou mahele lāʻau (1 mg no kg).

Hamo Cuticura "Amphotericin B": kauoha no ka hoʻohana

Papa ma lalo o ka like o kana oihana inoa i loko o keʻena kūʻai lāʻau lapaʻau i ole kuai. No laila, no ka mea, o ka hope o keia ka lapaʻauʻia, e nīnau aku i ke kauka.

Inā e pono ai i ka mea poni "Amphotericin B" lahilahi, ahu iho ua pili i ka hoʻohuli ai i nā wahi palua kela la i keia. Ka iapaau ana papa hilinaʻi nui ma luna o ka mea i loaʻa kekahi hōʻike:

• me ka candidiasis o ka ili bipi - ma kahi 1-3 hebedoma;
• me ka diaper poʻe noʻonoʻoʻole i loko o nā keiki - ka hola 7-14 lā;
• me ka paronychia a interdigital hakahaka make ai - 2-4 pule.

ʻaoʻao waiwai

E hoomakaukau ai "Amphotericin B" e i ka kēiaʻaoʻao ole:

• headaches, ke kāʻili 'ana,ʻike ākea neuropathy, transient vertigo, encephalopathy;
• lilo o ka ikaika loa ka makemake, ka luaʻi, dyspepsia, nausea, gastralgia, diarrhea, hepatotoxicity, huʻi ake e loaa, jaundice, hepatitis, melena, haemorrhagic gastroenteritis;
• normochromic normocytic anaemia, leukopenia, clotting kāna hana, thrombocytopenia, agranulocytosis, hemolytic anaemia, eosinophilia, leukocytosis;
• blurred hihiʻo, lohe poho, diplopia, tinnitus;
• tachypnea, dyspnea, pulmonary edema, arrhythmia a me ka hypersensitivity pneumonitis;
• ua hoʻemi a mahuahua ke koko, ka ohane, loli ma ECG kiko'î, naau e hemahema, kŰia, naʻau ole;
• anaphylactoid reactions, kiheʻana, nephrogenic mimikō insipidus, bronchospasm, nephrocalcinosis, poʻe noʻonoʻoʻole, eksfoliativiy dermatitis,ʻawahia epidermal necrolysis
• ʻaʻa puʻuwai ole, hypokalemia, gipostenuriyu,ʻaʻa puʻuwai omo acidosis, Stevens - Johnson maʻi pale, huʻiʻaʻa puʻuwai e hemahema, oliguria, anuria;
• thrombophlebitis, a kuni i ka mea ma ka ka pahu kui paena;
• wela, myalgia, ke kaupaonaʻana poho, arthralgia, mau nawaliwali.

hihia o ka overdose

I ka lawelawe nui nā māhele o ka lapaʻauʻia ka hoomanawanui i paʻa hanu a me ka naau. No laila, i loko o ka papa o ka Inc E ikaika hoopili aku i ka paipai laʻau heluna kauka. Ua mea no hoi e pono ai ke kanaka hoʻoponopono i ka ÷ naehana hanu a me ka cardiac,ʻaʻa puʻuwai a me ka ake hana,ʻike ākea koko kiʻi, e like me kona maʻiʻo o electrolytes.

Hoʻokaulike a me nā lāʻau

Ka medicament "Amphotericin B" hiki listen a attenuate i ka hopena o ka 'ē aʻe ai', e like me ka hoomahuahua i ko lakou kaʻawahia. Nolaila, ua k ua hoakaka ia me ka mālama nui i loko o ka iapaau ana.

Ma ke kauoha o ka mea i olelo hope a hiki i ka hoomanawanui, eʻoiaʻiʻo, e hai aku i kou kauka e pili ana i ka lawe 'ē aʻe ai'. I ole ia, i ka hoʻohana 'ana o "Amphotericin B" (intravenous) i e detrimental i ke ola kino a me ka nohona ma maikaʻiʻana o ke kanaka.

kekahi koi

• Ka lāʻau 'o "amphotericin B" e e hoʻohana wale no o ka iapaau ana o ke ola-na olelo hooweliweli au, a e holumua ai fungal nā mea palahēhē.
• Me ka hooloihi ae i hoʻohana no ka likelihood oʻawahia loa, piʻi pū.
• A hiki i ka hoʻohana 'ana i ka lāʻau' E e hele anaemia.

Reviews

Ano, e ike ana i ka lāʻau 'hana "Amphotericin B". Ka wehe a me ka ia inoa mea,ʻaʻole ma luna o kuai i loko o keʻena kūʻai lāʻau lapaʻau. No laila, no ka mea, ku una hooponopono, oe e koho i kekahi lāʻau me ka like ana.

E like me ka hapa nui o nā mea maʻi, noʻonoʻo i ka mea e pono Makuakane me ka hana. Ua ua pono loa lakou hana fungal ili lesions, ke kāpaeʻana physical a me ka manaʻoʻike discomfort o ka hoʻomanawanui.

I ka papa kuhikuhiE drawback o keia k mea he nui helu o kaʻaoʻao loa. Ma lapaʻau, keia mea paahana adverse reactions kānāwai ma ka aoao o nā mea a pau nā loko, a nenoai. Nolaila, he mea pono e hoopili wale i loko o kūikawā nāʻikepili.