Antileukotriene ai 'o ka mea hou hanauna: i ka papa inoa o ka mea maikaʻi loa

Antileukotriene ai 'ho i ka hou papa o ka Luna e emi i ka hoʻoʻino keʻano o ka hanaʻana i nā allergic a infectious etiology.

I mea e maopopo i ka loina o ka hana ana i kēia mau ai ', e mea pono e maopopo ka mea na leukotrienes.

leukotrienes

Ka mea, he poe uao o ka li nui. E like me kā lākou Nine Inch 'ole, ka mea e momoma nāʻakika, a i hanaʻia o ka arachidonicʻakika.

Leukotrienes i komo i loko o ka ulu ana o ka asthma. Like pono me histamine, ka mea, he poe uao o allergic reactions o keʻano koke. Histamine hiki i ka kokololio akā pōkole-makahiki bronchospasm a me leukotrienes i hoʻopaneʻe 'ia ana a me ka hou spasm.

Like hoʻolaha antileukotriene ai '?

Currently, e hoʻolaha leukotrienes like penei: A _4, B _4, C _4, D _4, E _4.

Hoʻololi kemikala o leukotrienes loko mai arachidonicʻakika. Ua mea ma lalo o ka aoao o ka 5-lipoxygenase loaa e leukotriene A _4. Ma hope iho o ia mea, he cascade naoh, i kūpono i ka mea kēia palapala leukotrienes B ₄ -C ₄ -D ₄ -e _4. I ka hope loa huahana o keia naoh - LTE _4.

Hookupaa i LTE _4, D _4, E ₄ hiki i bronchoconstrictor kanawai, mea ulu o ka mucus secretion e hoʻonui i ke kūpono 'ana o ke edema, inhibit mucociliaryʻae.

B _4, D _4, E ₄ i chemotactic haʻawina, a laila e,ʻo neutrophils a me eosinophils ma ka hoʻoʻino kaʻina ciia.

ʻepekema, ua hoike ia leukotrienes i hua mai ma macrophages, kia keena, eosinophils, neutrophils, T-lymphocytes, a i pili 'ole i ka hoʻoʻino reactions. Antileukotriene ai 'ma ka asthma ua pinepine i hoʻohana.

Ma hope o na keena e hele mai i loko o hui 'ana me ka allergen a me ka huʻihuʻiʻana ana Hawaiian Airlines' ole ma hope o physical exertion, ho'ā 'LT hoʻololi kemikala. I ua, ka hoʻololi kemikala hoʻomaka ka wā o ka osmolarity o bronchial maʻiʻo, piʻi pū.

Lau pūʻulu o ka ai '

Ua ua manawaʻikeʻia ma nā mea a pau eha pūʻulu antileukotriene ai ':

1. "Zileuton", a mea he pono inhibitor o 5-lipoxygenase.
2. Mea haʻilula keimikala i nā mea kūpale floppy, ao kaʻina o ka pū'āʻana i ka kumuʻiʻo me arachidonicʻakika.
3. "Zafirlukast", "Pobilukast", "Montelukast", "pranlukast", "verlukast" i nā hakaka o ka leukotriene receptors sulfidopeptidnyh.
4. Ai 'i nā hakaka o ka leukotriene B ₄ mea loaʻa.

Ka loa aʻo i antileukotriene ai 'o ka pae mua, a me ka kolu o ka pae ana o kālā. E hoomanao i kēia mau pūʻulu i hou au mamuli.

"Zileuton"

"Zileuton" mea he reversible inhibitor o 5-lipoxygenase. He hiki ke inhibit i ke kahua sulfidopeptidnyh Ka LT a me RT _4. Ka lāʻau 'ke i bronchodilator' ole ka loihi o mai i elima hola. No hoi ia mea hiki ke pale aku i ka hanana o bronchial spasm, i mea heʻilihune o ka waiū i anu ea ole "aspirin".

He haʻawina ke hooiaio i "Zileuton" häʻawi mai ai iä nā mea maʻi e loaa ana mai ka bronchial asthma no kekahi i eono mahina, ke emi i ka pono no ka mea hoʻomanawanui e ana β2-agonists a me corticosteroids. A hookahi mahele lāʻau "zileuton" ao ka hanana o ke kiheʻana a me ka pokole o ka nasal hanu i loko o nā mea maʻi i hana eha iaʻi mai allergic rhinitis ma hope o nasal hooponopono o ka allergen.

Na eono-hebedoma Inc me "zileuton" atopic asthma hōʻike he nui result. Kauka nei kiʻekiʻe-kbps hakumakuma o eosinophils a me neutrophils. No hoi, ka mea, ua hoʻemiʻeho necrosis ololi ma bronchoalveolar lavage fluids ma hope o allergen type hōʻike. I ka mea i kū hoʻokahi antileukotriene ai ', i keʻano papa hana o ka' ana ua nānā 'ana ma luna o kēia.

"Zileuton" ua wehewehe aku ma ka kŘpa a pōkole manawa, i ka wā i loaʻa o kona hapa-ola. Ua paipai i ka lāʻau e e lawe pinepine lawa i eha manawa i ka lā. Eia hou kekahi, "Zileuton" hiki ke hoemi i kaʻae o ke theophylline. Ua pono e noonoo, ina ka mea, ua ea ae ia laua loaa theophylline a "zileuton". Ia mea, e e hoemiia ka mahele lāʻau mua. Inā "Zileuton" ua ia ka lōʻihi-makahiki, ia mea pono ke kanaka hoʻoponopono i ke kiʻekiʻe o ke akepaʻa nā'ūhū.

Akā, loaʻa antileukotriene hou hanauna o ka ai ', kā lākou papa ua hoike mai ia ma lalo nei.

Konohiki i nā hakaka o leukotrienes sulfidopeptidnyh, nā kānaka hoʻokūkū i hoomaikai e wae, a reversible blockers LT D ₄ receptors. Mau ai 'nā "pranlukast" "Zafirlukast", "Montelukast."

"Akolat" ( "Zafirlukast")

"Zafirlukast" 'aka "Akolat" o ka loa? Anoee o keia pae ana o antileukotriene lāʻau' ona. Ua mea iʻeleu bronchodilator kohoʻia. Ke kanawai mau no ka hala loa o ka lōʻihi manawa, i ka i elima hola. "Zafirlukast" kaʻina mea hiki ke pale aku i ka ulu ana o ka asthmatic naoh i loko o ka hihia o ka allergen inhalation. Kona laulā ua maopopo, a me ka Kāohi bronchial spasm, a ua hoowalewale mai la ia ma ka anu ea, aspirin, physical haʻawina, pollutants. ʻeleu lāʻau, a me ka makaukau "Montelukast" hiki i ka hōʻoi 'i ka bronchodilator ha awina o ka β2-agonists.

"Akolat" ( "Zafirlukast") i maikai absorbability, ua loaʻa kona piko lehulehu i loko o ke koko ma hope o ekolu hora mahope iho o kona hooponopono. Kona hapa-ola au o iki hou ma mua o ka "zileuton", a me ka 10 hola. Eia hou, ka mea, i ole ia ma kaʻae o ka theophylline. ʻaeʻeleu lāʻau e e kekahi i ka hora mua o ka palaoa a me ka loko, elua no hora mahope, mahope mai o kaʻai nunui ho'ēmi i kā kona omo nona iho. O ia hoʻi, tolerated loa luawai.

ka hopena

Antileukotriene ai 'no ka allergies hiki ke hoʻohana' ia no nā keiki, akā,ʻaʻole ma mua e hiki i ka makahiki o ka elua. Me ke kōkua o kēia mau lapaʻauʻia i loko o nā keiki ia me recurrent bronchitis, allergic rhinitis, mehana asthma.