"Meropenem": aʻo no ka hoʻohana, nāʻana. lāʻau analogues

Ma kemikala antibiotics nā carbapenems pae, he 'elele o ka i mea i ka lāʻau "meropenem" no parenteral hooponopono. Ma muli o ke bactericidal a me bacteriostatic hana o kaʻeleu lāʻau ke keʻena mea hiki ke inhibit i ka ulu a me nā'ōlelo o ka koʻohune a i likeʻole hoʻoʻino maʻi.

Description lapaʻauʻia

Ka medicament "meropenem" Ua noʻonoʻo i ka laulā-pae antibiotic a mea he keʻokeʻo paha keʻokeʻo me ka melemele tinge ka pauka no ka pāʻoihana. Kikokiko i intravenous bolus paha infusion.

Hookuu aku ia i loko o hue i ka buke o ke 10 a me 20 ml. Ke laʻau heluna o ka lyophilisate ua 0.5 g. A 1 g. O ka lāʻau "meropenem". Papa a me injectable pāʻoihana no intramuscular ka pahu kui ka hoʻohana 'ana i ka antibiotic i lawe. Aia He hoʻokahi wale ke ano o ke kala.

i ka lāʻau

Kaʻeleu ke keʻena hana ma ka meropenem trihydrate palapala. Ma ka hōʻike o ka haku mele 'ana, ho omaulia ma ka hue 1, Hōʻike i ka nui o ka hana waiwai: meropenem trihydrate o 0,570 g., A 1.140 g., A, ma muli o ka noa meropenem 0.5 g. A 1 g., Niioaaonoaaiii. Ano he kumu hoʻohālike o kākoʻo waiwai nā paʻakai kalepona ka pauka.

Main counterparts a me kā lākou mau Manufacturers

Original lāʻau meropenem ua ka nānā 'ana i ka lāʻau' "Meronem" i loko o ka palapala o ka lepo a hiki i 0.5 g. Ua ua hoʻohana 'ia no ka hana ana i ka pahu kui i ua lawelawe intravenously. Kēia antibiotic ua hua mai ma Pelekāne poe "Astra Zeneca Co., Ltd.", ma muli ma a hoʻomohala i ka haku mele 'ana a me ka laʻau heluna o ka lāʻau, i mālama' ia ka mālama '-lapaʻau a me ka lapaʻau e hookolokolo ai. Other hoomakaukau me ka meropenem e manaoia nōhie a paʻi ma ke ano o ka palapala.

Ma nōhie "Meropenem" analogues loaʻa me ke kalepa inoa, coinciding me ka hoʻonohonoho 'ole-kūpono inoa, a ma lalo o ka hana' ē aʻe ma mua o ka loaa hale hookipa. Hookuu aku oia i palapala, laʻau heluna a me ka haku mele 'ana o ka "Meronem" lāʻau a pau o ka nōhie laau lapaau ma ka like o ka mea hookahi, i Hōʻike lākou interchangeability.

I ka lāʻau a me ka oihana inoa "Meropenem" hua mai ma na mea he nui mea lāʻau lapaʻau nā hale hana a pau ma luna o ka honua. No ka laʻana, ka mea Indian huakai "M. J .. Biopharm Pvt. Co., Ltd. "hana ka ka lapaʻauʻia, a ua lawe aku i ka'ōpala mai i loko o ka Lūkini huakai CJSC" Biotec MFPDK ". Ukrainian poʻe "Lekhim", "Pharma Life" i hua mai la i ka antibiotic "Meropenem". Analogs e komo i loko o kona inoa i ka inoa o ka Hookah. Ano he kumu hoʻohālike i loko o ke ao nei o ka hale kūʻai lāʻau lapaʻau hailona. Ma 'ana, me ka ike e hoʻomākaukau ai "meropenem Vero". He He huahana o ka Pākē poe "Shenzhen Haibin mea lāʻau lapaʻau Makeke .. Ltd ".

Medicament "Meropenem Dzhodas" - Mauna mea like o ka laulā-pae antibiotic hua mai la ia e LLC "Dzhodas Ekspoim". Ua ua hua mai la i ka pauka ano no ka hana ana o ka pahu kui pāʻoihana 500 mg a me 1000 mg.

Russian poe "ABOLmed" LLC i ka lapaau "Meropenabol" ma ke kumu o ka antibacterial Agena meropenem. Mai ka lepo, he pāʻoihana no intravenous hooponopono.

Uluwehi O "Meropenem Spencer»

Kēia mea paahana o kekahi Indian analogues i kēia manawa, "Cooper Pharma" no ka "Spencer UKey Pharma Limited", India. Hua mai la ma ka meropenem trihydrate palapala, a pili i ka carbapenems pae. Antibiotic "meropenem Spencer" hōʻike he antibacterial kanawai e ku e gram-maikaʻi a me ka gram-io koʻohune i ka hoʻoʻino a me ka infectious maʻi. Hoʻohana 'ia no ka parenteral hooponopono.

pharmacological waiwai

I ka papa kuhikuhiE hopena o ka waiwai meropenem manual iienuaaaony he bactericidal hana o ākea pae, a ua pili i suppression o ka ho okumu ana i mea koʻohuneʻili lahilahi. Ke hiki e i ka make ana o aerobic a me ka anaerobic koʻohune aie i antibiotic anal ma ka pa o ka microorganism, inert me ka pili ana i ka Hoʻokolohua-lactamases a me ka nuiʻo Solomona i ka hale a kumuʻiʻo, binders penicillin.

Ma ka paa ana i kumuʻiʻo receptors ma kaʻili lahilahi o ka cytoplasm o koʻohune hoemi peptidoglycan papa o ka halepaahao paia a me ka suppression transpeptidase kuu autolytic nā'ūhū i loko o ka halepaahao paia disrupting kona 'ole a me ka la ia e parasite make.

He aha microorganisms antibiotics?

No ka hoʻomäkaukau ' "Meropenem" aʻo ma ka noi komo ai i ka hoʻohana' ana o Anati-Gram-oluʻolu aerobes, i loaʻa Enterococcus fekalis, Stafilokk aurelus, Streptococcus agalactia, Streptococcus pneumonia me ka pā lonoaʻili i ka
penicillin, Streptococcus piogenez, Streptococcus viridans.

Ke kiʻekiʻe antibiotic hana ku e Gram-io aerobes, i waena o i Escherichia coli ua kaʻawale, Haemofilus influentsa, Klebsiella pneumonia, Neisseria meningitidis, Pseudomonas aeruginoza, Proteus mirabilis.
Meropenem hana ma anaerobic koʻohune, e like me: Bakteroides flagilis, Peptostreptokokkus spp.

I ka laulā o ka lāʻau i hoopaa aku i na kēia mau koʻohune ma lūmaua noiʻi wale, akā,ʻaʻole nō he hoike o ka lapaʻau laulā.
Gram-maikaʻi aerobes lawe Stafilokokus epidermidis me ka metitsillinovoy pā lonoaʻili a me Gram-io aerobes: Atsinetobakter spp, Aeromonas hydrophile Campylobacter Jaejoong, tsitrobakter diversus, tsitrobakter Freund, Enterobacter cloaca, Hafnie, Klebsiellla oksitoka, Morakella katarrhalis, Morganella Morgan, Pasteurella multotsida, Proteus vulgaris. , Salmonella spp., Serrat martsestsens, Shigella spp., Ursino enterocolitis.

I lūmaua hakakā anaerobic koʻohune :. Bakteroides distasonis, Bakteroides ovatus, Bakteroides uniformis, Bakteroides ureolitikus, Bakteroides vulgaris, Clostridium difficile, Clostridium perfringens, Eubakterium lentum, Fuzobakterium spp, Prevotella bivia, Prevotella intermedia, Prevotella melaninogenika, Porfiromonas asaharolitika, Propionibakterium aknes.

I Hawaii lāʻau

Aie i ka laulā huahelu o ka hana ana i ka hana waiwai meropenem aʻo ma ka paipai hoʻohana no kela infectious a me ka hoʻoʻino kāna hana me he hookahi medicament a ma ka hui pu ana, Inc.

O nā ka antibiotic-ikepili koʻikoʻi nā mea palahēhē ka hoohuoi ana:

• lalo naehana'āpana, hoikeia ma ka li nui o na ia maʻiʻaʻai, me nosocomial pneumonia;
• urinary'ōnaehana like pyelonephritis, pielita;
• ili a me ka pahee'aʻaʻa i loko o ka palapala o erysipelas, pyoderma, kiʻekiʻe iho mailoko o dermatoses;
• nā loko ma nā pelvis, me li nui o ka mucousʻili lahilahi o ka uterus;
• nā loko ma ka abdominal lua, a me ka moku'āina o ka huikau appendicitis, peritonitis, pelvioperitonita.

Uluwehi O hōʻike hopenaʻoi loa i ka mea koʻohune meningitis a me ke koko maʻiʻaʻai. People me febrile neutropenia, ka antibiotic hoʻohana ma ka hui pu ana, me ka antiviral a antifungal paha.

Na rula o ka lāʻau pāʻoihana

Noho male 'ana i ka lāʻau' koi adherence i aseptic a me ka antiseptic kaiapuni. Nā hue i ka pāʻoihana hoʻohana hookahi ua i aeia ka poʻe hoʻohuihui na ai 'antibiotic a me ka' ē aʻe.

Antibiotic "meropenem" i loko o ka palapala o ka sterile injectable he lepo lā ua nāu kekahi me ka wai no ka hou intravenous bolus. E hoike mai 1 g. O ka meropenem ka hoʻohana 20 ml o ka wai, a hoʻopili like ai i ka lehulehu o ka 50 mg no 1 ml. Ke hoomakaukau loli Ua nō kāu maopopo, colorless a malamalama-yellow nuance.

I ka hiki ana o 50-200 ml hana maʻalahi infusion pāʻoihana'ūheheʻe "meropenem" hoʻomākaukau. Mau nā:

• paʻakai koloriside 0,9%;
• dextrose 5% ai 10%.

Mua intravenous hooponopono o ka nāu kekahi wai i naueue.

laʻau heluna hoʻoponopono

Makua lapaau "Meropenem" manual hoʻolako i ka mahele lāʻau o 500 mg, a ua hai hou ma hope o 8 hola. E like me keia noaia malama ia no elike pneumonia, urinary'āpana nā mea palahēhē, infectious a me ka hoʻoʻino maʻi i loko o ka poe uuku pelvis nā loko, nā mea palahēhē o ka ili a me ka Muscle'aʻaʻa.

Nosocomial pneumonia, peritonitis, septicemia, symptoms o ka mea koʻohune nā mea palahēhē ma febrile neutropenic nā mea maʻi e noi mai ana antibiotic ana 3 manawa i ka lā no ka 1 makahiki I meningitis paipai mahele lāʻau o ka 2 g. Kela 8 hola.

Ke kaumaha ma muli o ka oolea a me ka 'ano o ka maʻiʻaʻai i loko o ka hoʻomanawanui ka wae kauka dosing a me ka lōʻihi o ka nohoʻana.

Nō kāu, o ka lōʻihi like manipulation hilinaʻi nui ma luna o ke ano o ka hooponopono. An intravenous bolus hanai i ka nāu kekahi pāʻoihana ua lawe mai no ma kahi o 5 minuke, a me intravenous infusion o - mai ka 15 a hiki i 30 minuke. Medicament "Meropenem" im i komo.
Maʻiʻaʻa puʻuwai 'ole pono? Iaea dosing i kulike ai me ka creatinineʻae :

• ma 26-50 ml no minuke, o ka mahele lāʻau mea mai 500 mg i 2 nā huna kela 12 hola;
• ma 10-25 ml no minuke, o ka mahele lāʻau mea mai 250 mg i 1 g., o kela mea keia 12 hora;
• emi iho malalo o 10 ml no minuke, o ka mahele lāʻau mea mai 250 mg i 1 g., i kekahi manawa, o kela mea keia 24 hola.

Mua nā mea maʻi me ka maʻamau ana, a me kaʻaʻa puʻuwai creatinineʻae i oi mamua o 50 ML no minuke dosing kohoʻia koho. Ake ole mea,ʻaʻole he kumu no ka mahele lāʻau hoʻoponopono.

Ma hemodialysis he mea excretion o meropenem, a me ka lāʻau ua lawelawe i ka pau ana o ke kaʻina hana. He mea oi loa aku hoi oiaio no ka hoihoi hou ana i lōʻihi-makahiki lapaʻau i ka hoʻokō koko lehulehu o ka antibiotic.
Ma nā kamaliʻi kanaka kahiko, i 12 makahiki 3 mahina i hoʻohana intravenously 10-20 mg o ka lāʻau no 1 kg kino ke kaupaonaʻana i ka wā mawaena o 8 hola. Laʻau heluna hilinaʻi nui ma luna o ka pathogen a me kona pā lonoaʻili i antibiotics a me ka maʻi.
Inā keiki ma lalo o ka makahiki o 12 i ke kino kaumaha aku i 50 kg, ka mea i hāʻawi makua mahele lāʻau.

Meropenem Inc o na keiki me ka hihia hoʻi hakuʻala kuleana pili i ole, ua? Anoee.
Ma ka iapaau ana o ka meningitis ma ka hoʻohana 'ana i 40 mg no 1 kg o ke kaupaonaʻana, ma hope o 8 hola.

Keia hana ua contraindicated

He nui e ike i ole ai ka lāʻau a pau hiki ke hoʻohana ', o ka oi aku ia he mea ka mahuahua hypersensitivity i keia antibiotic, a me ka mea e like Hoʻokolohua-lactam antibacterial Luna i loko o ka hala.

Small keiki mai ka 3 mahina mai,ʻaʻole i koi 'ia ka lapaʻauʻia, "Meropenem". E hoike hōʻike i ka pili ana o ka mea i ai 'i iʻawahia' ole ma luna o nā puʻupaʻa, a me ka digestive maʻi.
Ma hāpai keiki, i ka lāʻau 'ua ole ia, me ke koe o ka hihia ma ka pomaikai o ka antibiotic aku i ka detrimental ia ma luna o ka ulu o ka unborn keiki. Umauma-, e ai ana i lapaau ia,ʻaʻole e waihoʻia kauka.

ʻaoʻao waiwai

Ma ka la hoomalolo "Meropenem" lākiō i hōʻike i ka hiki 'ana o ka adverse loa i loko o nā wahi likeʻole o ke kino.

Ko mākou hopohopo'ōnaehana a me ka naʻauao lākou nā loko e pane i antibiotic hoike ana o ka headache, pōniuniu, numbness paena, tingling a me ka tingling, ikaika mea naʻau arousal, hoʻopōʻino ike paka, epileptiform kāʻili 'ana, convulsions.

Ma ka mea'ōnaehana mānowai koko'ōnaehana, nā loko hematopoiesis e hoʻomākaukau ai i ka hopena maikaʻi ia pili me ka ulu helu o eosinophils a me platelets i loko o kaʻike ākea koko wai koko, a me ka emi ana ma ka platelet a me ka leukocyte keena, hemoglobin pae, hoemiia hematocrit waiwai, a me ka helu o nā neutrophils, e alakai i ka agranulocytosis, hua'ōleloʻo thromboplastin a me ka prothrombin manawa.

Kekahi hoʻomanawanui iki mai kaʻina hana loli pili i na nā loko o ka gastrointestinal'āpana, hoikeia ma kaʻeha i loko o ka abdomen, nausea, ka luaʻi, diarrhea, constipation, indigestion, jaundice. He hiki hoonuiia pae o bilirubin i loko o ke koko wai koko kekahi, mahuahua ka ha awina o na nā'ūhū alanine aminotransferase, aspartate aminotransferase,'ākilikai phosphatase, a me lactate dehydrogenase. Ma pohihihi keia hoopii, ka mea e hoʻomōhala ana i ke ano pseudomembranous colitis, a me waha mucosa lesions ikeia candidiasis.

A ua noho hihia o ka 'aʻe' ana i ka heluna o ka genitourinary nenoaiu. Mau nā: ole ma ka urination, haanou ana o ka pahee nā'aʻaʻa o ka moku'āina, ma ka 'aʻe o ka hakuʻala pili me ka hypercreatininemia, e māhuahua urea pae i loko o ke koko, hematuria, thrush.

Antibiotics hiki ke keʻano o allergic reactions. Ka mea, hoike aku ma ka ohane, poʻe noʻonoʻoʻole, urticaria, erythema multiforme, Stevens-Johnson maʻi pale,ʻawahia epidermal necrolysis, angioedema, anaphylactic kŰia.

I waena o nāʻaoʻao waiwai, ma laila nā hōʻike manaʻo o ka leaching o potasiuma mai ke kino, mahuahua i ka buke o ke koko i loko o ka systemic holo, he maikaʻi nā moʻopuna aʻauhau'ēʻaʻe antiglobulin Coombs. Local reactions ma intravenous hooponopono e pili me ka li nui, phlebitis, thrombophlebitis, haanou ana a me ka soreness ma ka ka pahu kui paena.

Kekahi hoʻomanawanui iki mai i ua pili me ka ʻaoʻao 'ole o ka antibiotic hallucinations, kaumaha, irritability, Kanikani'āʻula, naau e hemahema, naau e hemahema, tachycardia, bradycardia, myocardial naau Muscle, ke koko, kulu, pokole o ka hanu, maʻule hou ihola nō a me ka uunu nui, aole nae i kekahi kūlana meropenem mau symptoms .