'O ke kino kanaka - nā mea ola

Interferon kanaka i loaa i ka 1957 ma nā kānakaʻepekema Isaacs a me Lindemann. Mahalo i kēia'ike'ana, ua ho'okumu'ia kekahi mechanical hou no ka pale'ana i nā pūnaewele kanaka mai nā ma'i viral. Ho'opili'ia nā mea kākau wīwī kahe ma ka ma'i hānai, i kāko'o'ia e ka CAM, a ua loa'a i ka mea i'ike'ia e kāohi i ka ulu'ana o ka ma'i ma ka CIR. 'O ka mea i hana'ia ma ka homogenate ua kapa'ia'o interferon, a'o ka mea ola wale nō no nā makahiki he nui i mana'o'ia he pale pale anti-viral. Ua ho'okumu'ia'o nā kinona o nā'ano like'ole o nā kānaka a me nā holoholona e lawelawe ana ma ke'ano o nā mea hana. Kona ho okumu ua poloʻai pule ma nā mea hoʻomaʻi, koʻohune i kekahi mau mea uuku, pathogenic fungi, protozoa, keiki mitogens kemikala polymers. Hiki i nā Leukocytes ke ho'oku'u i ka pilina o ka interferon i nā lā he'ekolu mau hola ma hope o ka ho'onui'ia'ana o ka ma'i.

Pono e'ike'ia he mea lō'ihi loa ka'ike'ana i nā mea'ino. Ho'okumu'ia ia i ka hiki ke palekana i kahi kanaka e kū'ē i ka hana o ka ma'i huakō me ke kōkua o nā kumu o ke kū'ē kū'ē'ole, inā i ka manawa like a ma mua paha i komo ai kekahi'īlio kūpono'ole i loko o kēlā'ano'ano like'ole. 'O kekahi mea like,'o ia ho'i, ua'ike'ia ke'ano o ka hihia ma waena o nā ma'i pathogens o ka huakino i ka hopena o kā lākou hui. Ho'opa'a'ia e hiki i kekahi'ano o ka mea ho'opunipuni ma'i ke ho'opau i ka pa'i'ana o kekahi'ano'ē a'e a pēlā e ho'ololi ai i ka papa o ka hana ho'opili i hana'ia e ia. Ua hō'oia'ia i ka wā i loa'a ai i kekahi kanaka ai'ole nā holoholona i nā ma'i paakiki, ho'oikaika lākou i ka palekana i ka ulupala. Ho'ākāka'ia ka pilina ma waena o brucella a me tularemia. Aia kekahi kumu e mana'o ai e hana'ia ka pale'ana o nā huapona i loko o ka macroorganism, ka mea e hana ai i kahi kūpono'ole no ka noho'ana o kekahi o nā ma'i pa'akikī.

E like me nā ikepili, ka mea, ekolu ano o ka interferon (gamma-'ōnaehana paleʻea, fibroblast Hoʻokolohua a me Alpha leukocyte interferon), a oko ma ka molekumu o, physical a me ka liluwelo ano. Pono e'ōlelo'ia ka pale'ana i waena o nā ma'i'ino i hana'ia me ka komo'ana o kekahi mea ho'onāuki kūikawā, i ho'oulu'ia e nā pū o ka'ōpū ma'i.

Ua hō'oia'ia he pilikino kanaka e pili ana i nā peptide biologically i hana'ia i loko o nā pūnaewele ma hope o ka ho'onāukiuki'ana o nā mea ho'opuka. 'O ka ho'omohala'ana i ka mea pale, kahi hiki ke kāohi i ka hana ola o nā ma'i'ele'ele i loko o ke kino, e lele ikaika loa ana. 'O ka mea i ma'alahi i ka hana o nā interferon he mau mea'ele'ele i loa'a i loko o nā membrane a me nā lipid waho (myxoviruses, arboviruses, nā ma'i pu'upu'u li'ili'i),'oiai he pīkolekole ko adenoviruses a me adenoviruses i waho a'oi aku ke kū'oko'a i kēia kumu. Eia nō na'e, aia kekahi mau hō'ole, i ka wā i loa'a nā'ōpiopio i kēia shell, e hō'ike i ka ho'onui i ke kū'ē i ka hana o nā ulia pōpilikia (herpes viruses).

Ke Ku'ikahi kanaka

'O ka mea nui e ho'oulu ai i ke kūkulu'ana he mea nui ia e ka lehulehu e komo ai i kahi'ele'ele nucleic i waho o ka pūnaewele, e hō'ino i ka pilikino ma'amau o nā pu'upu'u o nā hui like'ole. A stimulus aho hana mea hoʻomaʻi nukeleaʻakika ma vertebrate holoholona keena, eia nae'ē aʻe nukelea nāʻakika hiki ke malama i inducers o interferon. Ma waena o nā pūnaewele o ka pūnana microbial i ho'ākāka'ia e ka hopena o ke kino, nā endotoxins o ka hua bacteri kapi'ole, a me lipopolysaccharides a me polysaccharides, ma pyrogenal, prodigiosans kekahi i ko'iko'i ko'iko'i. Hiki ke ho'opili'ia ke kino o ke kanaka ma kahi e hō'ike'ia ana i nā pale a me nā huapalapala RNA, kahi i palekana'ia e kū'ē i ka hopena hopena o ka ribonucleases.

No nā'ale'a o ka mea pāpālua, me ka'ike'ole i nā mea pāpālua e pili pono i nā ma'i, e pili ana iā lākou ma o nā pu'upu'u li'ili'i, e hō'ole ai iā lākou i ka hua'ōlelo viral. I mea e hiki ai i ka mea kelepona ke ho'ākāka i ka hopena antiviral, pono e loa'a i nā pūnaewele mahele'ole ke'ano o ka pūnaewele RNA pūnaewele a me nā pūnaewele pūnaewele.

Nei, e like me ka mea antiviral Agena lawelawe "kanaka recombinant interferon alfa 2". 'O ke'ano o ka hana antiviral e pili ana i ka hana'ana i nā hana palekana ma nā pūmene viral non-infect. Ua hoʻololi i nā waiwai o ka halepaahao membranes, a ua ālai 'ka anal o ka mea hoʻomaʻi i loko o ka halepaahao.

'O nā'ano kolakola o ke kikowaena e komo pū kekahi'ano kūpono,'o ia ho'i he hō'ailona koho o ka hana ma ka'ōpiko o kona'ano like. 'O kekahi la'ana, hiki'ole i ka pāpili i hana'ia e nā pūnaewele o ka'ōpoki moa ka pale i nā to'i a me nā meaola'ē a'e, a'o ka mea i hana'ia e nā leukocytes kanaka'a'ole mea hana ma nā holoholona. 'A'ole pono kēia waiwai a, i kekahi mau mea, hiki i kahi kikowaena o nā hua'ōlelo heterologous hō'ike i ka hana i kekahi'ōpena'ē a'e.