'O ke lā'au lā'au "Papaverin". E kōkua ka a'o'ana i ka noi

Ma waena o nā lā'au lapa'au i hō'oia'i'o'ia no nā makahiki he nui i nā ma'i, aia kekahi lā'au lapa'au e like me "Papaverin." Ke wehewehe nui nei ke a'o'ana i nā hō'ailona a me nā hopena o ka ho'ohana'ana i kēia alkaloid. Ma ke'ano, aia kēia mea i loko o ka opium. I kēia mau lā, ua hana pinepine'ia i ka synthetically. 'O kēia waiwai he lepo makamae, kahi momona i loko o ka wai'ona, e hiki ke ma'alahi i ka wai. He mea'ono loa ka'ono o ka lepo. 'O ka hopena aqueous o ka waiwai ua paila'ia no 0.5 mau hola ma kahi mahana o 100 ° C.

Uluwehi O "papaverine" pili ia i miotropnym antispasmodic. Ho'oemi'ia ka hana pilikino a ho'oha'aha'a i ke kani o nā mīkini pa'alulu, he hana antispasmodic a vasodilating. Ua makaukau ua hoʻohana 'ia e like me ka antispasmodic ka wā i ala apuupuu Muscle spasm (no ka cholecystitis, pilorospazme, spastic colitis, spasms o ka urinary'āpana),ʻike ākea vascular, bronchial, lolo moku. Ma mua koke iho nei, ua ho'ohana pinepine'ia ke'ano lapa'au no ka pale'ana i ka hō'eha'ana o ka angina pectoris. 'O ka lawe'ana i ka lā'au "Papaverin", ke a'o'ana i loko o ia mau mea e pili ana i kona mau waiwai maika'i, pono e ho'omana'o'ia i nā pani ki'eki'e he mea ia e kāohi ai i ka ho'ohui i loko o ka intracardiac, e ho'ēmi ai i ka hili o ka pu'u o ka na'au. 'O ka lā'au lapa'au ke ho'oha'aha'a ke koko.

'Oiai'o nā kauka ke kau pinepine nei i ka lā'au "Papaverin" i nā ma'i,'a'ole i'ōlelo'ia e ke a'o'ana'a'ole i ho'omaopopo maopopo'ia ke'ano o kāna hana ma ke kino o ke kanaka. 'O kēia mea he mea ho'olālā o phosphodiesterase, he enzyme e ho'oulu ai i ka ulu intracellular o ka monophosphate adenosine cyclic. 'O kāna kāpili'ana e alaka'i aku ai i ka emi'ana o ka'olu'olu o ka musculature a me kona ho'omaha'ana i nā kūlana kaulike.

I ka manawa pinepine, me kahi promedolom e koho i kahi lā'au "Papaverin", ke a'o'ia e hiki ai iā'oe ke ho'ohana me ia me nā hua'ōlelo antispasmodic a analgesic. Ke hana'ia nei ke'ano o ke'ano ho'okele no ka ho'opau'ana i ka hō'eha'ana o angina pectoris. Ho'opa'a pinepine'ia kēia lā'au i ho'ohui'ia me ka platyphylline, phenobarbital a me nā mea'ē a'e.

Ho'okomo'ia ka lā'au "Papaverin" i loko o nā papa (0.04 g) i nā pōkole o 10 pcs., I ampoules me ka 1 a me ka 2% solution o 2 ml, ma nā'eneke kūpono o 0.2 g.'O ka mea hana i loko o nā papa, hiki ke komo i loko o ka histogematic. 'O nā mea pale, e komo koke i loko o ka'ōpala pahū. Ho'opuka'ia ka lā'au lapa'au e nā pu'upa'a. 'O ka hapalua o ka noho'ana mai ka hapalua hola i 2 mau hola. Ho'ouka'ia i 60% o ka hopena o kēia waiwai ma ke'ano o nā pūhui like'ole (me ka glucuronic acid, phenolic).

'O ke kau lā'au "Papaverin",'o ke a'o'ana e wehewehe pono ai i nā'a'ai e lawe ai i nā lā'au lapa'au i nā ma'i o nā makahiki like'ole, pono e mālama pono i kēia mau kūlana. 'O ka hopena'oi aku ka hopena i nā hopena maika'i loa. Ho'ohālikelike'ia nā mākua i kēlā lā i kēia lā i ka manawa 3-4 i kahi'ai lā'au inu o 1 papa (0.04 g). E hā'awi i nā pilapula i nā keiki, ma muli o ka helu o nā makahiki, no ka manawa kūpono 3-4-manawa i loko o ia mau kuhi:

- 0,5-2 makahiki: 0.25-0,5 mau papa;

- 3-4: 0.5-1 papa;

- 5-6: 1 papa;

- 7-9: 1.5 mau papa;

- 10-14: 1.5-2'ao'ao.

Intramuscularly a ma lalo o ka ho'oponopono'ili i ho'omohala'ia i 1-2 ml (1; 2%). Pono a me ka lohi lawelawe i loko o ka aa koko 2% pāʻoihana (2.1 ml), e like me ka lāʻau hiki i ka hanana o atrioventricular aeie, ventricular fibrillation a me ka ventricular extrasystoles. Ma ke'ano o ka mana'o no'ono'o, ho'ohana ka luna i ka 0.003-0.03 g no ka'ai (e pili ana i ka makahiki). Ho'ohana'ia nā candles ma hope o ka ho'opili'ana o ke kepau.

Lawe ka lapaʻauʻia contraindicated me hypersensitivity ana, hypotension, kue o atrioventricular conduction. Mai lawe i ka lā'au lapa'au me ka nīnau'ole'ana i ke kauka. 'A'ole i ho'okumu'ia ka hopena a palekana paha o ia wā i ka wā o ka lactation a me ka hāpai'ana. No laila,'o ka lā'au "Papaverin",'o nā hō'ailona no ka ho'ohana'ana i ia wā i ka wā'oi'ole, he maika'i ke'ole e ho'ohana. I ka wā o ka lawelawe'ana,'a'ole i'ae'ia ka lama.