"Ursofalk": nā analogues, nā kuhikuhi no ka ho'ohana a me nā puka ho'oku'u

'O nā lā'au lā'au "Ursofalk" i nā'ōlelo a'o no ka ho'ohana'ana i ke'ano o ka lā'au lapa'au me kahi'ano nui o ka hana, i loa'a,'o kekahi, hepatoprotective, cholelitholytic, mau pono immunomodulating. Eia kekahi,'o ka lā'au lapa'au ke emi nei i ke ki'eki'e o ka cholesterol i loko o ke koko.

Mea waiwai

'O ka mea hana pa'a o ka lā'au lapa'au'o ka ursodeoxycholic acid. Aia ma kahi helu i ka bile o kekahi kanaka, akā no ka hopena o kekahi mau hana i ka hana o ke ake, i ka ho'omana'o a, no laila, hiki ke ho'emi'ia ka mea o ka waiwai ma ka bile.

Ursodeoxycholicʻakika like me ka papa kuhikuhi 'Oponopono mea noho ole wale i loko o ka hoʻomākaukau "Ursofalk". 'O nā analogues e pili ana i ka papahana a me nā waiwai pharmacological he mau lā'au like'o Ursosan, Ursoliv, Urdoksa. E kama'ilio kākou ma lalo.

Nā hopena uila o "Ursofalk"

• Ke hō'ike'ia nei ka hopena o ke koho'ana ma ka emi'ana o ka nui o nā waikawa hydrophobic i loko o bile a me ka pi'i'ana o kā lākou'ikepili i loko o ka lumen o ka'ōpū. Eia kekahi,'o ka lā'au lapa'au, ma muli o kona pilina'ana me nā mea hō'ili'ili ma ka haleum, ho'emi'ia ka'imi o ka wai'ona hydrophobic kahe.
• 'O ka hopena Immunomodulatory e pili ana i ka'oia'i'o e hiki i ka'āpana pervodexycholic ka mea e ho'ēmi i ka'ōlelo o nā molelaka HLA mua ma nā ma'i hepatocytes, a me nā mole o ka HLA'elua ma cholangiocytes. Eia kekahi,'o ka lā'au i ho'ohālikelike i ka inoa o nā cytokine pro-inflammatory.
• 'O ka hana cytoprotective ka mana o ka mea hana e komo i loko o ka lipid layer of the cell cell membrane, a ma muli o ka hopena o ka membrane cell, ua ho'omaika'i'ia nā mea ho'omalu.
• Hypercholesterolemic hopena ua ma muli o ka ka ho'ēmiʻana i loko o ka ileum omo a me ka emi ana naʻokoko hoʻololi kemikala ma ke akepaʻa, a pēlā hoʻi me kona excretion i loko o ka bile.

Ma waho o ka luna 'ole, i ka lāʻau "Ursofalk" (kuhi no ka hoʻohana mea e hoikeike)' ano apau loa i ke kinowai aniani me ka naʻokoko lātoma e ho'ēmi i kā lithogenicity bile. Ma muli o ka ho'ololi'ana i nā pūpū cholesterol, ke emi nei ka hana'ana o nā pōhaku a me ka hemo'ana.

'O Pharmacokinetics

Ma hope o ka ho'oponopono waha'ana o ka lā'au lapa'au i loko o ka'ōpū li'ili'i, lawe'ia ka absorption o ka waiū pursodeoxycholic, me ka lawe'ana ma ka lawe'ana i ka halihali i ka haleum ma ka pū'ulu pahu, a ma ka passive transport i loko o ka jejunum a me iliac ma ka'ao'ao ki'eki'e. Ho'ohālikelike kahi 60 -80% o ka hapalua i'ae'ia i hā'ule i loko o ke kahe o ke kahe.

Ho'opili'ia ka mea hana i loko o ka na'au a ho'oka'awale'ia kekahi hapa i loko o ka'ōpū, kahi e alaka'i ai i ka'eha'ehiku'ehiku-keto-lithocholic'ehiku, a lilo'ia i loko o ke kahe o ke koko i kahi'ano'ole a ho'opau'ia i loko o ke ake. 'O ka hapalua o ka lā'au lapa'au'ekolu ia mau lā. 'O ke kumu, ua'āpono'ia me nā feces i ke'ano o ka metabolites.

Nā kuhikuhi no ka ho'ohana

'O nā lā'au'ae lā'au "Ursofalk" no ka ho'ohana'ana e hō'ike i ka ho'ohana'ana no nā ma'i o ka gallbladder, hānai, me ka ho'onui'ia o nā cholesterol blood, cholestasis, a emi iho ma kekahi mau hana. Ma waena o ia mau ma'i, ka ulia o ka ate (primary), ka bilary reflux-gastritis, ka cholangitis (sclerosing cholangitis), ka bilary reflux-esophagitis, ka ma'i hepatitis o ke'ano aiology,'ike i ka cystic fibrosis.

Ho'okumu'ia ka lā'au lapa'au i mua o nā pōhaku i loko o ka gallbladder, akā inā he X-ray kino wale nō,'o ke anawaena'a'ole'oi aku ka nui ma mua o'umikumamālima minuima, a'o ka mea ma'i'a'ole i ho'onele i ka hana'ana o ka gallbladder. i hoʻohana 'ia i loko o ka hihia o ke akepaʻa kaʻawahia (e laʻa me, ka waiʻona kaʻapu kōheoheo) ke medicament ua, kona pathology pu ma ka cholestasis (i loko o na keiki), biliary dyskinesia, atresia o intrahepatic bile ducts. Kona lawe nā mea maʻi ma parenteral kino, ma ka mea e hoʻopau stagnation o ka bile, e like me kanaka, ka poe i iʻoki kino no ke ake transplant.

Ma ke'ano he mea hō'oko'a e ho'onohonoho i ka lā'au lā'au "Ursofalk" (hiki ke ho'ohana'ia nā'ano like'ole o ka lā'au lapa'au i loko o kēia mau hihia),'oiai e lawe i nā lā'au e hiki ai ke ho'ololi i ka hana o ke ake (he mau hana'alopeka hopena, mau lā'au lapa'au me ka ho'oikaika).

Ke'ano o ka ho'opuka a me ke kāwili'ana

Elua mau'ano o ka ho'oku'u'ana i ka lā'au "Ursofalk": ho'omaha (ua like nā hi'ohi'ona ma kahi'ē, hana'ia ma Switzerland) a me nā capsule (aia nā mea like me ka mea i hana'ia ma Kelemānia). 'O ka hua mua o ka lā'au lapa'au e ho'ohana nui'ia no nā keiki a me nā kānaka me ka pilikia e'ai. 'O nā capsules he gelatinous,'opaque, pa'akikī, ua pena'ia ka pāpale a me ke kino i ke'oke'o, i loko - nā pauna ke'oke'o a me ka lepo. Ho'onoho'ia i loko o nā pahu o 10, 25, 50, a me 100 mau'āpana. 'O ke'ano ho'olālā ke'oke'o, he ke'oke'o ke'oke'o, i'ike'ia i ke'ano o ke kūlike o ke'ano, ua loa'a nā'ōmole o ka makani, a he leho'a lemon. Hana'ia i loko o nā 250 ml puna, kahi i ho'okomo'ia kekahi loko.

He 250 miligramu o ka'epa pursodeoxycholic i loko o ho'okahi capsule o ka lā'au lapa'au, ma ke'ano like o ka mea waiwai i loa'a i loko o elima mau mileliters (ho'okahi ana'ohe) o ka suspension o Ursofalk. Ka malakeke maupaʻa kākoʻo eiiiiiaiou: glycerol, anhydrous citricʻakika, xylitol, propylene glycol, paʻakai koloriside, microcrystalline kelulose, benzoicʻakika, lemonaʻono, paʻakai citrate, maloko wai, paʻakai cyclamate. 'O nā mea'elua i loko o nā capsules he mau mea'onika paila, he dioxide, he sodium lauryl sulfate, kānoa kānana, magnesium stearate, gelatin, wai ho'oma'ema'e.

Pehea e lawe ai iā Ursofalk

'O ka lā'au ma ke'ano o ka ho'onohonoho'ana i ho'okahi o nā mea he pono e mālama i nā hola ahiahi. Ua'ānai'ia nā capsules me ka'ū'ole, a holoi'ia me ka wai i ka nui pono. E like me ka mea i'ike mua'ia, ua'oi aku ka maika'i o ka lā'au "Ursofalk" no nā keiki e like me ka ho'omaha (syrup). Pono e helu'ia ke kau'ana e ke kauka, ma muli o ke'ano o ka ma'i a me nā'ano o ke kino o ka mea ma'i. 'O nā'ōpona (ma kahi kaumaha o'elima mau kilokani) ma mua o ka moe e hā'awi'ia he hapaha o ka ho'oku'u'ana o nā pu'u i ana'ia.

'O ka ma'amau, me nā ma'i o nā mo'o,'o ia ka ho'ohana'ana i ka lā'au lapa'au no ka po'e ma'amau he 10-15 maukeli ka kilokika o ke kaumaha,'o ka hopena o ka ho'onāuki e mau mai nā mahina'eono a'elua i ka makahiki,'oiai'a'ole e'ōlelo'ia ka ha'i'ana i nā lā'au hō'ailona. No nā kānaka me ka lā'au bilary refopx esophagitis a i'ole biliary reflux gastritis, he 250 mg ka ho'ohana'ana o ka lā'au lapa'au i kēlā me kēia lā, he'umikumamāhā mau lā. Me ka sclerosing cholangitis a me ka biliary cirrhosis,'o ka dose o 10-15 mg i kilo kilokika o ke kaumaha ke kau mau'ia i kēlā me kēia lā, akā, inā pono, e ho'onui'ia ka nui i 20 mg i 1 kg. Ho'omaha mau ke olakino mai nā mahina'eono a'elua makahiki. 'O nā ma'i me Cystic fibrosis ke lawe i ka lā'au i kēlā me kēia lā ma kahi o 20-30 mg i ka kilokika o ke kaumaha ma luna o ka manawa'eono mahina a'elua makahiki. I ka hopena o ka hana'ino i nā ma'i, ua hō'ike'ia e lawe'ia ka lā'au lapa'au i kēlā me kēia lā o ka 10-15 mg i kilo kilokika o ke kaumaha no'eono a me'umikumamālua mau mahina.

'O ke lā'au lā'au "Ursofalk." Analogues

E ho'okohu i ka hō'ailona o ka lā'au lapa'au me nā lā'au'ona e pili like i ka waihona a me nā mea pharmacological.

• 'O ke lā'au lā'au "Ursosan". Ke hana'ia kēia huahana ma Czech Republic a me Germany, ma ke'ano o capsule wale nō e hana'ia. 'O ke'ano o ka hana'ana i nā lā'au lapa'au like ka like. Eia nō na'e,'o nā mea nāna e ho'oponopono, hepatologists, nā ma'i lapa'au hō'eha i ka nīnau o ia lā'au lapa'au maika'i loa: "Ursosan" a "Ursofalk", e like me ka lokahi e pane aku e maika'i e koho i ka lua. 'O kēia mau hopena ua hana'ia e nā po'e lapa'au ma muli o kā lākou mau'ike pono'ī a me nā loiloi ho'omana'o. Ke ho'ololi nei ka lā'au "Ursofalk" i ka ma'alahi ma mua o ke ana o ka nīnau, a ho'omaka koke ia ke'ano o ka hana o ke ake. Akā, mai ho'opoina i nā'ano pilikino o ke kino, hiki i ka po'e kōkua i ka "Ursosan" kōkua maika'i. Eia kekahi,'oi aku ka maika'i o kēia lā'au lapa'au:'o ka hō'ailona me 50 capsule e kū'ai'ia he 650-830 rubles, akā no 50 mau capukal o "Ursofalk" lā'au lā'au e uku i 850-1200 rubles.
• 'O nā kumu o "Urdoksa." 'O ka lā'au lapa'au kahi lā'au lapa'au. Eia na'e,'o ka'oihana kū'ai lā'au kū'ai e kū'ai mai ana i nā mea e pono ai i ka'āina'ē, a ma Rūsia wale nō ka hana o ka hana'ana i ka lā'au lapa'au. Hiki ke loa'a iā ia i loko o nā capsules,'o ke kumukū'ai no 50 mau'āpana i waena o 440-960 rubles. 'O nā lā'au lapa'au'elua e like me nā waiwai pharmacological,'a'ohe mea nui i ka hopena i hua'ia.
• 'O ke lā'au lā'au "Ursoliv." 'O ka lā'au lapa'au, e like me ka mea i hala, i hua'ia i Rusia. Ma ka manawa ho'okahi, ua'ike nā kānaka he nui loa ka mea i ho'okahuli i nā pōhaku i loko o ka momona. Akā, aia kekahi mau'oihana maika'i loa me ka lā'au lapa'au "Ursofalk". Ho'ohālike like nā capsules, no laila he pa'akikī e hā'awi i ka makemake i kēia a i'ole kēlā'ano. Inā'oe e nānā i ke kumukū'ai,'oi aku ka maika'i ke kū'ai aku i ka lā'au lā'au "Ursoliv", ho'emi ke ko'i - 460-905 rubles no 50 capsule.

Nā hanana pō'ino

He maika'i loa ke ho'ololi'ana i ka lā'au "Ursofalk" i nā ma'i. Ho'ohālikelike'ia nā loiloi'ana o ka lā'au lapa'au me ka palekana maika'i. I kekahi mau kumu, i ke kumu o ka ho'omalu'ana, ho'ololi'ia ka helu'ana o nā gallstones, e ulu ana kahi mushy stool, e'ike'ia nā ma'i ma ka epigastrium. Eia hou, hiki i nā mea'ele'e ke ulu i ke'ano o ka'ili'ili, ka hives. 'A'ole i hō'ike'ia i kēia lā kekahi hō'ike o ka loiloi lā'au lā'au.

Kū'ē

'O ke kūlana ki'eki'e o ke kanaka i nā mea o ka lā'au lapa'au ke kumu no ka hō'ole'ana e ho'ohana. Ke ku'i'ia ka lā'au lapa'au no nā kānaka me cholangitis, ka hopena o ke kēpau a me ka bile, ka cholecystitis li'ili'i. Mai kau i ke kau lā'au i nā ma'i e loa'a ana i ka hana ka'a o ka gallbladder, biliary colic.

Ka ho'ohana'ana i ka'ōpū a me ka lactation

Wahi a ka'imi noi'i,'a'ole e hō'ike ka'aila i ka mutagenic, teratogenic, hana ho'onāukiuki, akā'o kona hiki ke komo i ka pale hematoplacental a ho'ololi i ka papa o ka hāpai'ana'a'ole i a'o nui'ia. No laila, no ka lawe'ana i ka lā'au'awa'awa "Ursofalk" i ka hānau'ana o ke keiki, hiki wale nō inā pono inā pono a e like ho'i me ke kauka a ke kauka. Ke hele nei ka'ike o ka ho'ohana'ana i ka lā'au lapa'au i ka wā o ka lactation.

'O ka pilina me nā lā'au'ē a'e

'O ka ho'olauna like'ole o ka lā'au lapa'au me nā mea antacid i loko o ka alumini hydroxide, a me nā lā'au "Kolestipol" a me "Kolestyramin" hiki i ka emi'ana o ka absorption pūnaewele o ka mea hana. Hiki i ke lā'au lapa'au ke ho'ololi i ka mana'o nui ma ka plasma toto o ke lā'au lā'au "Ciclosporin." Inā he pono no ka ho'ohana'ana o ia mau lā'au, e lawe'ia lākou ma nā hola o'elua wale nō hora.