Hepatocellular carcinoma o ke akepaa:ʻike, Symptoms a me ka iapaau ana

N Ka maʻi 'aʻai o ke akepaʻa maʻi i pohihihi keia. Nui prostate Ka maʻi 'aʻai mea kiʻekiʻe, i mea metastatic. Ke iniiaiie ake hikoko pili holangio- a me ka hepatocellular carcinoma. Mau maʻi 'aʻai ke hoʻomōhala i loko o nā kānaka, a iwaena o na wahine (kākaʻikahi). Ma na keiki, mau hikoko i aneane loa ana. Ma opiopio nā mea maʻi i ulu akepaa Ka maʻi 'aʻai, loko mai embryonic'aʻaʻa - hepatoblastoma. Kēia pathology He pohihihi keia. Aneane pau, iniiaiie ake hikoko i manaoia e eʻano pākīkē. Ka mea, kūlana 'ka 5th wahi o ka palaho i ka maʻi' aʻai pathologies 'ole. Currently mākou e huli no ka hou 'ana, e hakakä ake maʻi' aʻai. Great E hana 'ia ma o kā ka loaʻa, a hoʻomāka'ōnaehana paleʻea Inc.

Description o hepatocellular carcinoma

Hepatocellular carcinoma - he maʻi 'aʻai o ke akepaʻa aeee i hooleiiaʻi mawaho atypia. I e like me nā iniiaiie oncological pathologies o ke kino, ka mea, he loa prevalent. Kēiaʻeho ua i kapaia hepatic aeea carcinoma. Ma ke alapine (frequency) o hepatocellular carcinoma i waena o na kanaka o ka 5th nui loa i loko o ke ao nei. Kēiaʻeho mea oi, he pono ole i loko o ke kino'āina. Ua pili ia i ka loa a me ka hikiwawe loa e holumua ai Ka maʻi 'aʻai, a mea pinepine ana ona. OʻAʻole pono i ka hopena oʻike, o ka maʻi, akā, i loko o kona aggressiveness a me ka hana e metastasize i nā nā loko. Kēia mea ma muli o ke ake perfusion.

A pau 'ano o ka maʻi' aʻai i heluʻia i loko o ka Mea Maluna International o Nā Maʻi (ICD). Like nā maʻi 'aʻai pathology, ka mea, i kona mau kūikawā kivila, a me hepatocellular carcinoma. ICD-10 ua hoʻohana 'ia i loko o nā'āina o ko ke ao nei. I ka Mea Maluna o ka maʻi i ke kuhi S22.0, a 'o ia hoʻi "akepaʻa aeea carcinoma." Loa pinepine, i kēia pathology ia lŘlŘ ku ei ke kāʻei kua o ka maʻi rula, ma lalo o ka aoao o adverse aʻe.

Kumu o ke ake carcinoma

E like me uaʻike, ka etiology o malignant hikoko i ole i ua? Anoee. Eia naʻe, ua lōʻihi loaʻa maiʻepekema i Makaʻu hoʻonāukiuki aku i ka hooulu ana o kaʻeho. No koe a hepatic aeea carcinoma. E lawe mai ia ia i ka hahai ole:

1. Lōʻihi-ʻia nā moku halihali mokulele o kekahi nā mea hoʻomaʻi. Ua Ua manao ia pathologies e like me maʻi hepatitis B a me C, hoomahuahua i ka pilikia o ka ulu hepatic carcinoma e oi aku mamua o 100 mau manawa. Eia hou, i kēia mau maʻi i pinepine asymptomatic. No laila, e emi i ka pilikia o ka maʻi 'aʻai E e ke kamepiula E lūlū mai ke koko ma luna o nā mea hoʻomaʻi hepatitis.
2. Ake cirrhosis o kekahi etiology. Hope o hepatocytes i loko o ka connective'aʻaʻa pinepine ia lŘlŘ like me ka hopena o ka maʻi mea hoʻomaʻi maʻiʻaʻai,ʻai ana o ka waiʻona a me ka ai '.
3. Ai ana i ka ai waiwai ma ka aflatoxin.
4. Aaiaoe predisposition i ka maʻi.
5. Komo hepatotoxic ai '.

Inā mākou e hookaawale ia i ka helu 'ia ma precipitating kumumea, o ka pilikia o ka ulu hepatocellular carcinoma mea ka palena haʻahaʻa. Aka hoi, aole kekahi mea'ōnaehana paleʻea, mai keiaʻeho. Like nā maʻi 'aʻai pathology, ka mea e ho i waiū i ionizing pāhawewe, pūnuku puhi, no kou kino, stress, a no laila, ma luna o. D.

Ke pathogenesis o hepatocellular carcinoma

E like me ka hopena, maʻi li nui maʻamau ake keena hoʻomaka e hoʻololi iʻeho hehee wale. He aha kēia nui hiki aku ai i ka mea e lākou. Manawa i ka hana o ka mea hoʻomaʻi o ke akepaʻa'aʻaʻa ua wela ai, i ke kino i edematous, a ola. vascular permeability, piʻi pū, ka mea, e piha-koko. Nolaila, ke papa akepaʻa ua hihia hoʻi. Kaawale mai ka mea i ke kino e luku i ka mea hoʻomaʻi (particles), ka mea, he aha ka mea'ē aʻe nā palapala 'ona e hele mai ana, mai ka ai. A pau i kēia hiki aku i ke kelepona hele hou '. Ke Kernel ulu ma ka nui, o ka cytoplasm a me nā organelles e 'oni iki i ka periphery. Ma hope o ia, o ka halepaahao hoʻomaka e puʻunaue unmotivated. Ua loaa i ka iiiaanoaa o nuclei, hepatocyte pūnao i hehiʻana. Ma o ka halepaahao, i kaʻeho hoʻomaka e synthesize nā polokina i palahalaha ae hoʻomaka koke ma ke koko. Pela interconnected Hepatitis C a me Hepatocellular Carcinoma.

Ua hoʻomanaʻoʻia ai ia ia ia mea he mea hoʻomaʻi maʻi kokoke mau alakai i cirrhosis o ke akepaʻa a me ka maʻi 'aʻai. Ma ka hapanui o na hihia, ka mea, ua ano complications e ala mai ka wā diagnosed. Kekahi inoa no ka hepatitis C - "ka lokomaikai pepehi". Keia mea aie a hiki i ka piha kaawale o ka lapaʻau hoike ana mai o ka maʻi no na makahiki, a me ka imminent makeʻana i ka hopena o ka hoopau ana o ka functioning o ke akepaʻa.

Mea Maluna o hepatocellular carcinomas

Hepatocellular carcinoma ake ua maheleia i loko o kekahi mau lapaʻau a me ka morphological 'ano apau loa. Eia hou, i kaʻeho hoi hoʻolaha, e like me ke kahua o ka? Acaeoey a me degere o ka oolea. Ke kaumaha ma muli o ka macroscopic kiʻi kaʻawale wahi, nunui, a eiei? Ano o ke akepaʻa Ka maʻi 'aʻai. Manaoia he okoa? Ueo fibrolamellar hepatocellular carcinoma. E like me ka lapaʻau kiʻi, he 6 ano o ke akepaʻa aeea carcinoma. I waena o lākou:

1. Gepatomegalichesky koho.
2. Icteric palapala.
3. Febrileʻano o ke akepaʻa Ka maʻi 'aʻai.
4. Ascites palapala.
5. Huʻi abdominal koho.
6. Metastatic ake maʻi 'aʻai.

Loa pinepine ka mea, he huihui 'ana o kekahi mau lapaʻau Lolina. Ke kahua ake-aeea Ka maʻi 'aʻai hilinaʻi nui ma luna o ka nui o kaʻeho a me kona prevalence i loko o ka wahi a lymph aka wahi, a me nā loko.

Hepatocellular carcinoma: na symptoms

Symptoms hilinaʻi ma ka lapaʻau 'ano o ka carcinoma. Ma ka hapanui o na hihia, na kahua o ka hoʻonaʻauao i kakahiaka nui o ka maʻi 'aʻaiʻaʻohe symptoms. Eia hou, i kaʻike, he pono no i ka mea i kaʻeho symptoms e hoohalike ai i ka lapaʻau kiʻi o nā akepaʻa maʻi (maʻi hepatitis, cirrhosis). Ma ka hopena o Ka maʻi 'aʻai hoikeana nā haʻahaʻa-papa wela, lilo o ka ikaika loa ka makemake, nawaliwali, lymphadenopathy, ke kaupaonaʻana me keia poho. Ka wā gepatomegalicheskoy ano o ka carcinoma ike i na hiohiona mahuahua ma ke akepaʻa, eha ma ka hypochondrium akau. One-hapakolu o nā mea maʻi i jaundice Lolina o pathology. Ua loaʻa i kaʻilihune prognosis. Jaundice ia lŘlŘ i loko o ka mua elua a me ke kahua o kaʻeho.

Eia hou, e hoomanawanui i ohumu o kaʻeha a me ka maneo. I ka febrile palapala ia mahuahua ma ke kino ana wela a eia i, kaʻawaʻawa loa aching ka waiʻona ma ke ana ma ke keena abdomen. Ascitesʻia i loko o nā kuʻina nui o ka maʻi 'aʻai, heʻeho ua pu ma na symptoms o intoxication. Emi, he pono ole huʻi abdominal shape. Ua Ua wehewehe aku ma ka loa eha, Muscle hoʻopilikia abdominals. Koho no ka metastatic hepatocellular carcinoma Kīwala'ō ma na hoailona o'ē aʻe nā loko. Iwaena o lakou - na iwi, ia maʻiʻaʻai, liʻiliʻi.

Morphological ano o ke ake carcinoma

Morphology palapala hikoko pee no kēia:

1. Nunui hepatocellular carcinoma. Ua lawe he okoa Hoʻohana a lobe o ke akepaʻa. A hiki aku ka mea e oki ai, he akaka palena. I uuku foci (ukali) hiki e noho i loko o kaʻeho paena. Kekahi o nāʻano likeʻole o ka papakaukau akepaʻa Ka maʻi 'aʻai ua manaoia e lilo i kekahi ano o ka abdominal. I mahele ia akullaʻeho paena, maloko, a he mea he mea eleele wai. Lua pa mānoanoa a me ka laumania.
2. Nodular hepatocellular carcinoma. Wehewehe aku ma ka iiiaanoaa o kaʻeho foci aia ma ka parenchyma kino ili honua.
3. Eiei? Ake carcinoma. Loa pinepine e hoʻomōhala ana i ma luna o ke kāʻei kua o ka cirrhosis. A pau parenchyma ninoieo o na kumu o connective'aʻaʻa a me'āno'ē keena.

Fibrolamellar carcinoma ninoieo o kekahi a me kekahi mau nui hoʻopunipuni. Ma ka hapanui o na hihia ka mea, ua IIeEeAIEUIeXAIIUE i loko o ka lobe hema o ke akepaʻa. Waihoʻoluʻuʻeho - yellow paha omaomao. Kekahi hoʻokaʻawale palapala ua manaoia e e encapsulated (uuku), hepatic aeea carcinoma. Ua Ua wehewehe aku ma ka maikaʻi prognosis a me ka ulu lohi,ʻeho nui ka emi o 5 knm ma anawaena.

ʻike, o ke ake hepatocellular carcinoma

He mea pono ke hana i kekahiʻano o examinations mua, e kuhikuhi i na maʻi like hepatocellular carcinoma. Pathologyʻike, he o kekahi mau kahua o ka hoʻonaʻauao. Mua, ke kauka hoʻolohe i nā mea a pau ahonui hoopii a me ke nānā pono. Mau noonoo ana ua uku i ka ili (ʻano, alo raschosov, hemorrhage), lymph aka wahi, palpation o ke akepaʻa. I Ka maʻi 'aʻai o ke kino i ka bumpy ili, anuanu hionapāʻili, ia no ka palupalu. Mahope, i ka helu o ke ana. I waena o lākou:

1. KLA, ke koko kemika.
2. Hoomaopopo ana i ka nui o kūikawā hōʻailona - Alpha-fetoprotein.
3. Ultrasonography o ka abdomen.
4. Me tomography.
5. Haʻawina hepatic moku. Mau nā angio a me ka portogepatografiyu.

ʻike, ua nānā 'ana i cytological a me ka histological nā haʻina. I hoʻomaka i kēia mau haʻawina, hana hui, biopsy.

Hepatocellular carcinoma o ke akepaʻa: iapaau ana o ka maʻi

Koho lapaʻau kou akamai hilinaʻi nui ma morphological palapala a me ka nui o kaʻeho, a me ke kahua o ka maʻi 'aʻai kaʻina. Ma nā kahua o ka hoʻonaʻauao loiloi mua o ka maʻi 'aʻaiʻoki kino ua hana, wehena o thyroid nodules, chemotherapy. Ma eiei? Hikoko hana embolization o hepatic artery. Kēia kōkua i ka 'ūlōlohi i ka ulu ana o hikoko, a kali i ke kaʻina. Hepatocellular carcinoma o ke akepaʻa mea ole ikepili koʻikoʻi i ka radiotherapy kūlana kanaka. Eia hou kekahi, ia mea kākaʻikahi amenable i ka chemotherapy, wale 15-20% o nā mea maʻi i ka pokole maikaʻi ia. Kekahi aoao, he ake transplantation. I ka ulu ''āina, keia iaoia Ua laha. Transplantation o kekahi mau pou hui, ua mālama 'wale ma na kahua o ka hoʻonaʻauao kakahiaka o ka maʻi' aʻai. Ma ke alo o ke kaawale ana metastases ua noʻonoʻo i ka wale ala e pono symptomatic Inc. Ua nā palliative malama (malama o ke hoomanawanui, psychotherapy) a me ka anesthesia.

ʻoki lāʻau lapaʻau lapaʻau o ke ake maʻi 'aʻai

ʻoki lāʻau lapaʻau 'uao ua lawe maiʻaneʻane a pau e hoomanawanui i ka poe i diagnosed me "hepatocellular carcinoma". Ka iapaau ana nā ake resection i loko o ka anatomical māhele 'āina (Hoʻohana kaʻana like hapalua kino). Inā liʻiliʻi-pepa paia pa alima i hana kona enucleation kūikawā aspirator. Kekahi iaoia meaʻoki kino - he percutaneous embolization o hepatic artery.

Ka loa ka hoʻokōʻaoʻao mea e transplant hui, a hapa paha. Ke akepaʻa'aʻaʻa i ka hiki e regenerate. He hiki ka hopena i loko o ka hoʻomanawanui ka piha ke ola.

Uluwehi O Inc ku e hepatocellular carcinoma

Ma waho aʻeo ia chemotherapeutic ai ',' Imi hoʻohana hou pharmacological pae o ka ai '- nā mea kūpale o kumuʻiʻo kinases. Lākou keia mea e emi i ka ka hoʻonuiʻana o kaʻeho keena. I loko nō o ka nuiʻaoʻao waiwai, i kēia mau ai 'i loa ka hoʻokō. An kumu o ka ai 'i loko o kēia pūʻulu o ka lāʻau "Nexavar".

Ke prognosis o hepatocellular carcinoma

Kekahi o keʻano pākīkē malignant hikoko gastrointestinal'āpana ua manaoia hepatocellular carcinoma o ke akepaʻa. Ke prognosis no keiaʻeho ma ka hapanui hihia noho lakou malaila. High 5-makahiki ola ana ua malama i ka poe liilii, nui like 'ole ho okumu ma hope oʻoki kino a akepaʻa transplantation wale. Pinepine ka mea, he recurrence o kaʻeho, a kokololio metastasis. Hoopau wale ana kino mea ona.

Kāohiʻana o hepatocellular carcinoma

Kāohi ana nā i ka makahiki ana i hepatitis nā mea hoʻomaʻi, hōʻole o ka ai 'a me ka waiʻona. He waiwai e hoomanao ana i ka li nui o ke akepaʻa i e loaa me ka hopena o ia mau manipulations like kahua niho a me ka nani kūlana kanaka, he koko transfusion.