Koko clotting. I ke ano o ke koko coagulation

Kekahi o na keʻano o ka hanaʻanaʻano nui 'ia i loko o mākou kino o ke koko clotting. Noaia ia e e ho'ākāka 'ia ma lalo nei (i hoakaka ia no illustrative hana, a me nā kiʻi). A mahope mai o ia mea i ka luna 'kaʻina, ia mea pono e noonoo ia i loko o au mamuli.

Pehea i ka mea hiki mai?

Ke'ī mai,ʻo ka hōʻike 'ana kaʻina mea kuleana no ka noho kahe ana ke koko, hang nei ma muli o ke poho i kekahi a me kekahi ke keʻena o ka vascular'ōnaehana o ke kino.

Ma na mea hua'ōlelo, ua hiki ke hoomaopopo ekolu kūlana. First - ho'ā hope. Ma hope o poino i ka moku e hoomaka i ana mahope reactions, a ho'ōla e alakai ai i ka ho okumu ana i laila,-kapa prothrombinase. Kēia - He luna 'iloko olaila ka V a me ka X coagulation kumumea. Ua ua hana ma luna o ka ili o plateletʻili lahilahi phospholipid.

Ka lua o ka pae - coagulation. Ma keia anu u, fibrin ua hana mai fibrinogen - kiʻekiʻe hakakino kaumaha kumuʻiʻo ia mea i ke kumu o ke koko clots, a me ka hanana o ka i komo ai i ke koko clotting. Ke ano i hoakaka ia ma lalo hōʻike i kēia pae.

A eia ka mea hope, ke kolu o ke kahua. Ua komo ai fibrin clot ho okumu, wehewehe aku ma ke anuanu 'ole. Ma ke ala, o ka holoi a me ka maloʻoʻana ia mea hiki ke loaa ka "mea" i ua laila, hoʻohana 'ia no ka makaukau o sterile huahuakai a me Film no ka noho kahe ana ke koko, kena ae la ia e rupture o na moku liilii, maʻoki lāʻau lapaʻau hana.

About reactions

Ma luna o ka mea, ua pokole ho'ākāka 'ia ma ka clotting o ke koko. Ke ano, ma ke alanui,? Ac? Hoʻi i loko o 1905 ma nä känaka 'epekema-coagulation, o Paul Oscar Morawitz. A ka mea, aole e lilo aku kona pilina a hiki i kēia lā.

Akā, nui ua loli mai 1905 i loko o ka naauao o ke koko coagulation like me ka luna 'kaʻina. Mahalo i ka holomua, o ka papa. ua hiki ke wehe i kēia ōlaʻi i ka hou reactions a me nā polokina i ka pae'āina i loko o kēia kaʻinaʻepekema. A me ka manawa hou aku e like me ka cascade noaia o ke koko coagulation. Mahalo i kona pokole, a me ka naauao o keia luna 'kaʻina loaʻa he wahi maʻalahi e maopopo.

I hiki ke ike i ka mea ma lalo nei kiʻi, mea, ke aha literally "i mai ma luna o nā pōhaku lepo." Lālau aʻela ia i loko o no ka na, a mawaho'ōnaehana - ke koko a me ka'aʻaʻa. No kela a me keia ano i ho'ākāka 'deformation ia lŘlŘ ma muli o ka pōʻino. I ke koko'ōnaehana poho noi vascular paia, collagen, protease (a pipili'ūhū), a me nā catecholamines (lātoma neurotransmitters). Ke'aʻaʻa Ua malama aeea poino like me ka hopena o i kekahi e hele thromboplastin. I mea nui he stimulator o ke koko clotting kaʻina (ole kapa coagulation). He hele 'ana i loko o ke koko. Kēia mea i kona "ala", akā,ʻo ia ka mea, he kūlana pale külana. Ma hope o ka mea, hoomaka thromboplastin clotting kaʻina. Ma hope o kona kala i loko o ke koko hoʻomaka manaʻo o ka luna ekolu kūlana.

manawa

No laila, aha e pili ana i mea he koko clotting, ua kokua ke ano e hoomaopopo. Ano, au makemake makemake e kamailio iki e pili ana i manawa.

Ka a pau kaʻina i kekahi i kā mākou o 7 minuke. I ka pae mua mau mai ka elima a hiki i ehiku. Iloko o keia manawa, prothrombin hana. Kēia waiwai a pau o keʻano o ka luna 'kumuʻiʻo kanu'ōiwi nā kuleana no ke kaʻina kahe o ke koko coagulation a me ka hanaʻia naʻe hiki. A ua hoʻohana 'ia ma ke kino i ka mea e ho okumu thrombus. He clogs ka poino paena, no laila, i ke kahe ana ke koko aɃe. A pau ia ai 5-7 minuke. Ke lua a me ke kolu kahua o ka hoʻonaʻauao lawe wahi he nui wikiwiki. No ka 2-5 kekona. No ka mea, i ka pae ana o ke koko coagulation (noaia haawi ma luna) loli ai i ka keʻano o ka hanaʻana i ana a puni. A me keia o ia hoʻi, e ma ka ino paena koke.

Prothrombin, ma ka huli, hua mai la i loko o ke akepaʻa. A me kona hoʻololi kemikala i manawa. Pehea koke paka lawa prothrombin, e hilinaʻi nui ma luna o ka nui o ka wikamina K na i loko o ke kino. Inā ka mea, ua nalowale, ke kahe ana ke koko, e pau ana pilikia. A ia mea he nui pilikia. Mai ka nele o ka wikamina K Hōʻike i ka 'aʻe' ana o ka hoʻololi kemikala o prothrombin. A me keia - ka maʻi e e hana.

noaaeeecaoee hoʻololi kemikala

Ua pono, o ka nui noaia o ke koko coagulation Ua maopopo - manawa e e haawiia mai kekahi noonoo ana i ke kumuhana e pili ana i mea e e hana, e hoihoi i ka koi dala o ka wikamina K i loko o ke kino.

I hoʻomaka me - eʻai pono. Ka nui dala o ka wikamina K ua loaʻa i loko o uliuli kī - 959 micrograms no 100 nā huna! Ekolu hea ana o hou, incidentally, ma mua o kaʻeleʻele. No ka mea, e 'Imi inu. Hana i ole a me ka lau - spinach, keʻokeʻo cabbage, nā komako,'ōmaʻomaʻo peas, onions.

I ka mōhaiʻai no hoi kekahi mau wikamina K, akā,ʻaʻole i loko o nā mea a pau - wale ma ka veal, pipi akepaʻa, ke keiki hipa hoʻokahi. Akā, i ka hope mea ka mea, ua haku o ka kālika, paʻi hua waina, ka waiu, Mele a me nā hua waina.

Eia naʻe, inā ke kulana mea nui, alaila, heʻano o menus, e kōkua e e pilikia. Nō kāu, kauka ikaika waiho aku i ka hui pu iho i kouʻai me ka ai 'i ka mea i hoakaka ia. Me ka lapaʻau E ole e hoolohi. He pono ai me ka hikiwawe e loaa no ia ia, e normalize ke koko clottingʻano papa hana. Ka iapaau ana regimen ua hoakaka ia ke kauka koke, a me ka mea, ua hoi nae, e ao aku ia oukou ina ua kāpae'ōlelo i nā koi mea e hiki mai ana. A me na hopena ke lilo i ake dysfunction, trombogemorragichesky maʻi pale, pernicious anaemia, ʻeho maʻi a me ka poho iwi lolo anei i keena.

Schmidt noaia

I ka pau ana o XIX kenekulia noho i ka physiologist kaulana a me ka HI. Kona inoa ua Aleksandr Aleksandrovich Shmidt. He noho no 63 makahiki a me ka hapanui o ka manawa hoolilo i ke ao hematology pilikia o. Akā,ʻo ia pono aʻo i ke kumuhana o ke koko clotting. He hoʻokele e hookupaa nui ae i ka enzymatic ano o ke kaʻina hana, no laila, i ke nä känaka 'epekema ia i manaoia i kaʻimi naʻauao wehewehe. A maopopo hōʻike i ke ano i hoakaka ia ma lalo clotting.

Ma ka wahi mua he mea he ka ho'ēmiʻana o ka moku poino. A laila, ma ka situ hanaia moe kolohe kina, ka iniiaiie platelet polokalamu mākaʻikaʻi. A laila ka mea, hoopaakiki hoi. Hiki ia ho okumu i ula thrombus (ole haawiia i like ke koko clot). Ma hope o ia mea, ua hapa 'ia' ole loa nā mea hoʻoheheʻe.

Ma ke kaʻina hana, hoikeia mai kekahi clotting kumumea. Ke kaapuni i loko o kona wehewehe nui loa akuʻano kekahi IeEeAUUXAAaO ia. Ka mea i hōʻikeʻia Apapika numerals. A ma laila nō i ka huina o ka 13. A o kela mea keia mea o oukou, e hai aku.

kumumea

A a puni o ke koko coagulation mea hiki ole me ka helu ia. Pono, ka mea, e hoʻomaka me ka mua.

Ololi I - mea he colorless kumuʻiʻo fibrinogen. Synthesized ma ke akepaʻa, ua hoʻopau ma Honolulu Airport. Ololi II - prothrombin, i i mua, ua kau aʻela ma luna. Kona hanana hiki mea e hoopaa i kalipuna Ion. A ka mea, ua laila ka cleavage o keia waiwai i hanaʻia clotting'ūhū.

Ololi III - ia mea he luna 'kumuʻiʻo lipoprotein,'aʻaʻa thromboplastin. Kona kapa ma ka amo ana o phospholipids, naʻokoko, triacylglycerols a oi.

Kekahi ololi, IV, i Ca2 + Ion. Ka mea i i ua hoʻopili ma lalo o ka aoao o ka colorless kumuʻiʻo. Ka mea, o ka pae'āina i na luna 'keʻano o ka hanaʻana, ma ka hou ana i clotting ma ka secretion o neurotransmitters, no ka laʻana.

Ololi V - ia globulin. A ua i hua mai i loko o ke akepaʻa. Ua Ua koi 'ia no ka paa ana o corticosteroids (hormonal waiwai) a me kā lākou halihali. Ololi VI kekahi manawa ma laila, akā, a laila ka mea i manao e hookaawale ia lana mai o ka Mea Maluna. No ka mea, ua loaʻa ka noiʻi - ia nā ka ololi V.

Akā, i ka Mea Maluna i ole hoʻololi i. No ka mea, ma hope o V hele ololi VII. Nā proconvertin, mai a ke komo 'ana i hana'aʻaʻa prothrombinase (mua pae).

Ololi VIII - he kumuʻiʻo i ua hoikeia ma ka ia pae. Ua ikeia like Anati-hemophilic globulin A. It mea no ka mea, o ka nele o ka ulu i ke nānā, ili maʻi, e like me hemophilia. Ololi IX mea he "pili" hōʻike muaʻia aʻe. No keia antihemophilic globulin B. ololi X - pono globulin, synthesized ma ke akepaʻa.

A eia ka mea hope, o ka hope ekolu wahi. Kēia ololi Rosenthal, Hageman a me fibrin noaaeeecaoee. Ka mea, eia, i loko o ka hoʻopiha, loli i ke kahua o intermolecular makaukau na kaula paa a me ka mea maʻamau functioning o ke kaʻina hana e like me ke koko clotting.

Schmidt kaapuni nā mea a pau o kēia mau kumumea. A heluhelu muli o kona kulana fluently ia pehea ka ho'ākāka 'ia ma kaʻina mea eiiieaena, a he nui kona mau manaʻo e maopopo.

anticoagulative kahua

Kēia manaʻo E hoi e kaulana noonoo. Ka luna i hoakakaia'ōnaehana clotting - noaia kekahi wehewehe i ke kahe ana o ke kaʻina hana. Akā, me ka ai-kapaia "protivosvortyvanie" kekahi e wahi.

E hoʻomaka, ka mea e e kaulana ia i loko o ka papa o ka evolution, ua Wehewehe i nā kānakaʻepekema mau loa ke alo pilikia. Ka mea, Ua ho'āʻo nei e pohihihi mai - ana i ke kino hooponopono iho i ke pale aku i ke outflow o ke koko, mai poino ipu koko, a pela e malama ia i loko o ke kinowai moku'āina i loko o ka a pau? Ua pono, o ka olelo hooholo o ka lua o ka pilikia i ka loaʻa o ke anticoagulation nenoaiu.

He He maopopo lākou o ka wai koko nā polokina i mea hiki ke hoemi i ka uku o Nine Inch reactions. I mea inhibited.

A i loko o kēia kaʻina hana 'ole antithrombin III. Kona papa kuhikuhiE kuleana pili i mea e mana i ka hana a kekahi mau aʻe i loaʻa i ke kiʻikuhi o ke koko coagulation. He nui e möakäka hou: ka mea, aole ia i hooponopono i ke kahua o ke koko clot, a eliminates ole nā'ūhū, trapped i loko o ke koko, mai na wahi a pau āna e hana. No ke aha la ka mea pono? E pale aku i ka laha ana o ke koko clotting i loko o ka koko wahi i ua hanaʻino wale.

pale hehee ai

E hai ana i ho i ka nenoaiu o ke koko coagulation (kaapuni Ua hoike mai ma luna), mālama E e kaulana ia waiwai like heparin. He He luaipele-i loaʻa kaʻakika glycosaminoglycan (he 'ano o ka polysaccharide).

Kēia - ka pololei anticoagulant. Waiwai ka paepaeʻana coagulation hope inhibition nenoaiu. Ua alalai mai i ke kaʻina hana o ka heparin koko clots. Pehea ke ano o keia hana? Heparin wale ho'ēmi i kā ka ha awina o ka thrombin i loko o ke koko. Naʻe, i kēia mea - he kūlohelohe waiwai. A me ka mea, e lawe pono. Inā mākou e alakaʻi mai i ka anticoagulant i ke kino, ka mea hiki ke hoʻonui i ka ho'ā hope o ka antithrombin III a me ka lipoprotein lipase (nā'ūhū e hoopili lakou triglycerides - i ka papa kuhikuhiE ikehu kumu no na keena).

Ano, heparin ua pinepine hoʻohana 'ia i loko o A iapaau ana o thrombotic ana. Wale kekahi o kona lātoma ke haʻalele i ka nui helu o ka antithrombin III. Alaila, heparin hiki e manao like i kekahi hōʻeleu - like i loko o kēia hihia o ka hana nae mea i 'ano like me ka like me ia, kena ae la ia e ia.

Aia i nā waiwai a me ka ia hana, iloko o ke koko wai koko. E lawe, no ka laʻana, α2- macroglobulin. He paipai 'ana i ka hālāwai hope o ke koko clot, e loli ai i ka kaʻina hana o ka fibrinolysis, lawelawe' ana i amo ai i ka 2-valent Ion, a me kekahi mau nā polokina. A nō inhibits waiwai 'ole i loko o clotting.

ae nānā mau hoʻololi

Aia o kekahi nuance mea, aole ia e hōʻike i ka hana kuʻuna noaia o ke koko coagulation. Ke physiology o ke kino o ua mea he nui o na keʻano o ka hanaʻana Komo ole wale Nine Inch loli. Akā, i physical. Inā mākou ke mālama i ka clotting i ka maka kapa ole, e makemake ike i ke kinona o platelets ma ke kaʻina hana o ka hoololi ia. Ka mea, e ua hoʻokōʻia keena me typical spinous keʻano o ka hanaʻana i ka mea e pono ai no ka manaʻo o ka mālama nui aggregation - hoʻohuiʻia nā kumu i loko o ka hoʻokahi pa alima.

Akā, i ka ole a pau. No ka mea, platelets i clotting anao? Aou kekahi mau waiwai - catecholamines, serotonin, etc. Ma ke kumu o ka lumen o na moku koko, i i poino, hou. Ma muli o ia a loaʻa mea he loiloi ischemia. Koko lako i ka pōʻino, ua make ke kina ole ua hoemiia. A, me, ka ia outpouring i nā hoemi ia a hiki i ka palena iki. Kēia i hāʻawi mai i ka manawa kūpono e aeie platelets poino wahi. Ka mea e, i ka lilo ana o ko lakou mau spinous keʻano o ka hanaʻana, me he mea "pili" a hiki i na kihi o ka collagen olona, a i aia ma ke kihi o kaʻeha. Kēia welau a ka mea mua, ka mea loihi ho'ā hope pae. Ua pau i ke kahua o ka thrombin. Ukali ma kekahi mau kekona pae o ka coagulation a me ka retraction. A me ka mea hope ke kahua - ka hoihoi hou ia ana o ka maʻamau koko holo. A me ia mea o ka nui. Mai ka piha hoola ana o kaʻeha mea i hiki ole i ka maikai koko lako hou.

pono e ike

Ua pono, i kekahi mea e like keia ma ka olelo a me ka nānā e like me ka Nohie kiʻikuhi o ke koko coagulation. Eia naʻe, loaʻa nō kekahi mau nuances, i au makemake makemake, e nana i ka mea kani.

Hemophilia. Ma ka mea i kau aʻela ma luna. He He mea weliweli loa maʻi. Kekahi kanaka kahe ana ke koko, ka mea, e ae mai oe, ua hoano e ikaika. Hereditary maʻi e hoʻomōhala ana i aie i ka mā i loko o nā polokina komo i loko o ka clotting kaʻina. Huai ae ka mea hiki e loa ai na mea - ma ka ikiʻoki kanaka nele i ka hailona o ke koko. A pana aku au i ka puu o ka manawa, e hooki ia. A me ka loa loaʻano o ke kahe ana ke koko ke hoʻomaka no i kumu. People pilikia mai hemophilia, e hoʻokuleana i kakahiaka kīnā o ke kino. No pinepine kahe ana ke koko i loko o ka Muscle'aʻaʻa (maʻamau hematoma) i loko o na ami - ia mea,ʻaʻole uncommon. paha ka mea, ua malamaia lakou nei,? Me kekahi pilikia. A kanaka e literally hana i kou kino e like me ka fragile ipu, a me ka manawa e ao. Inā kahe ana ke koko ia lŘlŘ - i ka manaʻo pono e hoʻolauna hou koko kona mau pou, a iloko ona i kakauia he ololi XVIII.

I hookuu i ka maʻi e loli ai na kanaka. A me nā wāhine hana i nā moku halihali mokulele o ka hemophilia'ōewe. Interestingly, ka Beritania Koroleva Viktoriya ua like. Kekahi o kāna mau keiki kāne pū i hiki mai. Like no ka mea'ē aʻe mau mea IKE OLE IA. Mai hemophilia, ma ke ala, ua pinepine kapaʻia ka maʻi aliʻi.

Akā, he mea ku pono ana hihia. Ua pili ia i ka māhuahua koko clotting. Inā ka mea, i, ka mea i pono, e ia ma ka liʻiliʻi loa pololei. Mahuahua clotting Hōʻike he kiʻekiʻe kamepiula o intravascular clots. I clog i nā ipu a pau. Pinepine i kaʻilihune i e ka thrombosis, pu ma ka li nui o ke aa koko pā. Akā, i kēia kina ua malamaia lakou nei, maʻalahi. Pinepine, ma ke alanui, ka mea, ua ka ho'ōla pānaʻi ai.

It ke kupaianaha i ka nui o ua hanaia ma ke kino o ke kanaka, i ka wa a ke kula haʻahaʻa a oki iho la i kekahi apana o ka pepa. Ua hiki e ka lōʻihi manawa e kamailio e pili ana i nā hiʻona o ke koko, clotting a me kona keʻano o ka hanaʻana e pili ana i ia. Akā, i ka loa hoihoi 'ike, e like me pono hōʻike kona manaʻo i hoakaka ma luna. A me ke koena, ina makemake, hiki ke lolouila pākahi.