Paʻakai valproate: beauty, na olelo, hookuu palapala,ʻano papa hana o ka hana, i ka haʻilula

Kekahi kāna hana o functioning o ka Central ko mākou hopohopo'ōnaehana he pono pili noonoo. E hakakā ulu nuipa a ka lapaʻauʻia me kekahi mau loina o ka hana i loko o ka lolo ia mau pilikia. Kekahi o ia mea no ka "paʻakai valproate".

I ka papa kuhikuhiE eiiiiiaiou a me ke ano o

I ka papa kuhikuhiEʻeleu 'Oponopono o ka lāʻau - ka paʻakai paakai o ka valproicʻakika - mea he olonā i mea pōaka keʻokeʻo he lepo lā ka ole ala. 'O kēia ke kala ano o ka lāʻau "paʻakai valproate". Haʻilula - S8N15NAO2. Hoopuni wailana i ka waiʻona a me ka wai.

Ke consumer Ua mōhai ma ka papa a me ka papalua-, ahu iho polyethylene mauʻeke. I ka mea uuku e hiki ka leo i loko o ka hoʻokahi AEeAaOA - 0.5 kg. E möakäka hou LAVEA: 1, 2, 5, 10, 20, 25, 30, 40, 50, 65 kg.

pharmacodynamics

Antiepileptic ai '- i ka papa kuhikuhi hana o ka la hoomalolo "paʻakai valproate". Keʻano papa hana o ka 'ana ua ma muli o ke kakali ana i mea ulu i loko o ka pae o Gaba ('aminoʻakika, mea he nui inhibitory neurotransmitter i loko o kānaka a me nā mammals) i loko o ka CNS ma inhibiting me Gaba-transaminase a emi i ka reuptake o ka waiwai i loko o ka lolo'aʻaʻa. Ke no ia mau hopena o kēia kaʻina, apparently, mea e emi i ka excitability a me ka susceptibility o Hawaii, iaono? O ka lolo a hiki i ke kūpono 'ana o ke kāʻili' ana.

Paʻakai valproate hiki i ka tranquilizing hookoia e ho'ēmi i ka iini, ka hoʻoikaika 'ana naʻau i loko nā mea maʻi, kā lākou noʻonoʻo kulana. Eia hou, ka mea hōʻike he antiarrhythmic hopena. Ke k hōʻike kiʻekiʻe ka hoʻokōʻana i ka wa e kaawale aku ke kāʻili 'ana (epilepsy symptom, kekahi' ano o ka epileptic 'ana) a me ke kino psevdoabsansah, akā,ʻaneʻane ole ia ma keʻano o nā mea maʻi me ka psychomotor ulu ana o ke kāʻili' ana.

Ka poepoe o ka ole o ka lāʻau

I ka papa kuhikuhiE noi o ka medicament "paʻakai valproate" manual regulates epilepsy, nā like monotherapy, a me ka hoʻohui pūʻia lapaʻauʻano. Ka lāʻau 'Ua hoʻohana' ia i loko o ke alo o ka generalized kāʻili 'ana (polymorphic, nui a me ka convulsive' ole. D.), A me ka hapa mea nui (Hawaii, psychomotor a me ka 'ole. D.). Eia hou, ua hoakaka i ka lāʻau no ka convulsive kāna hana i pinepine pu ma ke aloha maʻi o ke kanaka ua'emi'ōnaehana kāna hana 'ana e hele lima i loko o ka lima me ka epilepsy ma febrile convulsions a me ko mākou hopohopo tics i loko o nā mea maʻi-keiki.

Paʻakai valproate alakai ia kekahi eʻae nā mea maʻi me ka manic-depressive bipolar pono i loko o nā hihia ma ka maʻi mea refractory i ka lapaau me ka likiuma a me nā lāʻau.

I ole hoʻohana i kēia ka lapaʻauʻia?

Ma na eiiieaena huahana like Anati-epileptic, he mea mau i kekahi papa inoa o nā contraindications i kā lākou hana. Kekahi hiki ole lawe i ka Agena, ka mea i ike hypersensitivity i ka waiwai e like me valproicʻakika (paʻakai valproate, iho a me ka loaʻa o kona paʻakai paakai). Ke kumu no ka mea ole nā 'ano like o ke alo o ka iaea ooieoeiiaeuiiai abnormalities i loko o nā mea maʻi ake a me / ai pancreas. Mākou E hoi kahińuli ma keia pae ana mai Hepatitis (nāʻano a - huʻi, maʻi, lāʻau, etc., a me ka mōʻaukala o kaʻohana ..).

Ua 'Aʻole e koi' ia i ka lāʻau ma ka hemorrhagic diathesis, porphyria (aneane 99% o ka hihia o hereditary haiahū kūmau hoike ma ka 'aʻe' ana o pigment pūnao me kiʻekiʻe ka maʻiʻo ma ke koko a me nā'aʻaʻa o porphyrins).

paʻakai valproate a me ka hāpai keiki

I ka hoʻohana 'ana i ka lāʻau i loko o ka trimester mua o ka hāpai keiki ua contraindicated. I ka lua a me ke kolu o trimester kauka, e hoakaka ia ka lapaʻauʻia no ka āpana o "paʻakai valproate" kuhikuhi wale nō inā ke kakali ana i pomaikai no ka makuahine aku i Loaʻaʻia kamepiula no ke keiki.

Nā mea maʻi e e lohe ia valproicʻakika ke kāhea i ka hooulu ana o ka helu o congenital malformations i loko o ka fetus. Eia hou, ua waiwai ua excreted ma ka umauma waiu (lehulehu e hiki 10% o ka nui na loko wai koko o ka makuahine, o ka). Nolaila, umauma-e hanai ana oia i lapaau me na laau i loaʻa ka valproicʻakika i loko o ka haku mele 'ana, mea ana wale i loko o na hihia o ka lōʻihi mea.

E like me he ao hoike o na wāhine e noho ana i loko o kā lākou mau reproductive makahiki, o ka pono o ka ike loeaʻano a me kāu kiʻina hana o ka contraception.

undesirable 'ole

No ka hoʻomanawanui iki mai ia ia me ka lapaʻauʻia "paʻakai valproate" manual he 'ike e pili ana i ka hikiʻaoʻao ole o ka mea okoa nenoai a me nā loko.

Hiki naoh ma ka aoao o ka Central ko mākou hopohopo'ōnaehana i e ka tremor, loli ma ka naʻau i loko, hana, hoʻopōʻino ōhumu, sleepiness, pōniuniu, headache, irritability, restlessness a me ka hana a pīhoihoi.

ʻO ia paha naoh GIT - lilo o ka ikaika loa ka makemake, dyspepsia, nausea, ka luaʻi, diarrhea, uuku na naau oʻu cramps a me ka'ōpū wahi. He pohihihi keia, e lohe i constipation a pancreatitis. Ma nā wāhine, ka menstrual kalapona me ke kūʻokoʻa. Pinepine i ka wahi e e kaumaha fluctuations i loko o kekahi olelo a me kekahi. Coagulation'ōnaehana hiki pane thrombocytopenia, mahuahua nui o ka manawa koi kahe ana ke koko, e oki. Dermatological hiki deviations like alopecia (pathological lilo o ka lauoho), allergic - he poʻe noʻonoʻoʻole ma luna o kaʻili.

laʻau heluna regimen

Ka laʻau heluna regimen no kēlā me kēia hoomanawanui mea pololei kanaka. "Paʻakai valproate" kona shape kakau ana - i ka pauka palapala lawelawe ke kaumaha ma muli o ka kino kaumaha. Ka loiloi mua laʻau heluna no nā mākua a me nā keiki he nui ma mua o 25 kg mea 10-15 mg no kilogram kino paona (i kela la ka leo). Inā 'oe e ole hōʻike i e kekahi adverse hanana i nā (kela 3-4 lā) ka laʻau heluna hiki ke hoala hou ia 200 mg / lā. a laila, a he nui lapaʻau result, e e loaa. Ka awelika kela la i keia laʻau heluna i e mai i ka 30 mg / kg.

Iapaau ana Regimen lapaau - 2-3 manawa i ka lā iʻai.

Kekahi hana paha paʻakai valproate intravenously (allowable ko lakou hoomakaukau ana - 400-800 mg) ole infusion (25 mg / kg ma luna o ke au o ka 24, 36, 48 hola).

ʻO kā mākou hiki mahele lāʻau no ka iapaau ana o mākua nā mea maʻi a me na keiki me ke kino kaumaha oi mamua o 25 kg - 50 mg / kg no ka lā. Inā no kekahi kumu ia mea e pono (mahele lāʻau) mahuahua, he elue mea e kanaka hoʻoponopono i ka lehulehu o ka valproate i loko o ka haku mele 'ana o ke koko wai koko. Inā keia uku o ka oi ma mua o 200 mg / k - ka laʻau heluna e hoemiia e.

Excessive nā māhele

Inā no kekahi kumu ka mea, ua oi aku o ka mea ana mahele lāʻau "paʻakai valproate" (beauty ma Roma oluolu e maopopo loa i nā mea a pau nā mea maʻi), aia no he moʻo o unequivocal symptoms. Ka loa, he pono ole reactions i ka haunaele o ka Hawaii ōhumu a me ka koena, retardation, Myasthenia Gravis (pathologically ka luhi), hyporeflexia, nystagmus (involuntary maka fluctuations ma kiʻekiʻe alapine (frequency)), miosis (contraction o ka haumāna), naau aeie, coma.

Lapaʻau ua lawe mai i loko o ka haukapila i hoʻolilo 'ia a me ka gastric lavage mea (ka pono, i ka wa enterally loko o 10-12 hola), e hoolako i osmotic diuresis (nui ka leo o ka mimi me ka lehulehu kiʻekiʻe o osmoticʻeleu ke keʻena) a me ke kākoʻo o ka nui ke kino. Good hopena, oia ke hemodialysis.

AaOIeIOUIeXAOAaIN a me nā waiwai

Ma ka laua palapala noi me nā neuroleptics, antidepressants, Mao nā mea kūpale, kela benzodiazepine nā mea loaʻa ethanol a me ka paʻakai valproate māhuahua inhibitory ia ma luna o ka Central ko mākou hopohopo nenoaiu. Ka hui hoʻohana o ka lāʻau i ka hepatotoxic ai ', antiplatelet konohiki, anticoagulants, e hoʻonāukiuki loa ole o kēia mau waiwai.

Laua loaa ana o valproicʻakika a me ka phenobarbital kēpau e pohupani hale o ka mea hope, mai ka paa me ka wai koko nā polokina. No - hoomahuahua ia (phenobarbital) nā hoʻohui like me ka wai koko.

Nui, paʻakai valproate ke komo i loko o AaOIeIOUIeXAOAaIN me kaʻano o ka lapaʻauʻia, nae ka hiki (ole unacceptable)? Eaia o kona laua me'ē aʻe ai 'o ka hoʻomanawanui e hai aku i ka hana maikaʻi kauka.

Special ao

Me ka nui kaiapuni ka lapaʻauʻia i hoakaka ia i nā mea maʻi e loaa ana mai ka maʻi o ke ake, a me ka pancreas (a me ia mau mea i loko o ka mōʻaukala), na keiki elemakule ma lalo o 3 makahiki (i kā mākou pilikia o ka hepatotoxicity, akā, emi me ka makahiki). It E e kaʻikaʻiʻia ma ka manaʻo i ka pahiki o ka hanana o ka hopena maikaʻi 'ole, mai ka akepaʻa, a mahuahua nui iloko o ka hui anticonvulsant Inc.

, Ua hooikaika i kā lākou ola pono e hoʻomanawanui iki mai lawe "paʻakai valproate" a me ka ke koko dyscrasias. Ke aloha lolo maʻi, abnormalities ma hakuʻala hana, hypoproteinemia - mea no hoi he nui kamepiula kumumea no adverse loa.

Iloko o ka eono mahina o ka iapaau ana me ka paʻakai valproate mua mea nui e noke kanaka hoʻoponopono i ka moku'āina o ke koko coagulation'ōnaehana, akepaa,ʻike ākea koko kiʻi.

People lawe i kekahi lapaʻauʻia anticonvulsant, paʻakai valproate Inc e hoʻomaka i nā, no laila, e like me ka hoʻokō i ka hoʻokō mahele lāʻau o ka hola 12-14 lā ma hope. Ma hope iho o ia, e pono i ke kiʻekiʻe o ana i ka mua loaa anticonvulsant ai '. Inā ua hoomakaukau e i pili mua me ka hoomanawanui, ma ka pono ka mahele lāʻau no ka lapaʻau result e e loaʻa i loko o ka hebedoma.

E ku e ia E e ia i ke kāʻei kua o ka pono o ka lāʻau i ka wa alanui ana a me ka hana, e noi lehulehu o ka noonoo ana a me ka mämä holo o ka psychomotor reactions.

A me ka hapanui o importantly ...

Ke kumu no ka applicability o kekahi antiepileptic lāʻau (ʻaʻole i koe a me ka paʻakai valproate) - kuhikuhi i hoakaka ia kauka.

Wale ola hana ma ka oihana, e loiloi i nā mea a pau o nā kumumea, a hooholo i hoʻomaka Inc me ka ua lāʻau. Kaawale hoakaka o ka manao o fraught me ka hoʻoponopono 'inikua lako loa, loa io hopena no ka mea ola kūlana - mai e coma a me ka make.